nach oben

International Urology and Nephrology

Erschienen in:

31.03.2020 | Nephrology - Review

Factors affecting medication adherence among pre-dialysis chronic kidney disease patients: a systematic review and meta-analysis of literature

verfasst von: Jun Jie Benjamin Seng, Jia Ying Tan, Cheng Teng Yeam, Htay Htay, Wai Yin Marjorie Foo

Erschienen in: International Urology and Nephrology | Ausgabe 5/2020

Einloggen, um Zugang zu erhalten

Abstract

Background

Medication adherence plays an essential role in slowing the progression of chronic kidney disease (CKD). This review aims to summarise factors affecting medication adherence among these pre-dialysis CKD patients.

Methods

A systematic review of the literature was performed in Medline®, Embase®, SCOPUS® and CINAHL®. Peer-reviewed, English language articles which evaluated factors associated with medication adherence among pre-dialysis CKD patients were included. Meta-analysis was performed to assess the pooled medication adherence rates across studies. Factors identified were categorised using the World Health Organization’s five dimensions of medication adherence (condition, patient, therapy, health-system, and socio-economic domains).

Results

Of the 3727 articles reviewed, 18 articles were included. The pooled adherence rate across studies was 67.4% (95% CI 61.4–73.3%). The most studied medication class was anti-hypertensives (55.6%). A total of 19 factors and 95 sub-factors related to medication adherence were identified. Among condition-related factors, advanced CKD was associated with poorer medication adherence. Patient-related factors that were associated with lower medication adherence included misconceptions about medication and lack of perceived self-efficacy in medication use. Therapy-related factors which were associated with poorer medication adherence included polypharmacy while health system-based factors included loss of confidence in the physician. Socioeconomic factors such as poor social support and lower education levels were associated with poorer medication adherence.

Conclusion

Factors associated with poor medication adherence among pre-dialysis CKD patients were highlighted in this review. This will aid clinicians in designing interventions to optimise medication adherence among pre-dialysis CKD patients.

Nur mit Berechtigung zugänglich

El Nahas M (2005) The global challenge of chronic kidney disease. Kidney Int 68(6):2918–2929PubMed

Hill NR, Fatoba ST, Oke JL, Hirst JA, O'Callaghan CA, Lasserson DS et al (2016) Global prevalence of chronic kidney disease: a systematic review and meta-analysis. PLoS ONE 11(7):e0158765PubMedPubMedCentral

Wee H-L, Seng BJJ, Lee JJ, Chong KJ, Tyagi P, Vathsala A et al (2016) Association of anemia and mineral and bone disorder with health-related quality of life in Asian pre-dialysis patients. Health Quality Life Outcomes 14:94

Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351(13):1296–1305PubMed

Bartlett Ellis RJ, Welch JL (2017) Medication-taking behaviours in chronic kidney disease with multiple chronic conditions: a meta-ethnographic synthesis of qualitative studies. J Clin Nurs 26(5–6):586–598PubMed

Yeam CT, Chia S, Tan HCC, Kwan YH, Fong W, Seng JJB (2018) A systematic review of factors affecting medication adherence among patients with osteoporosis. Osteoporos Int 29(12):2623–2637PubMed

Schmid H, Hartmann B, Schiffl H (2009) Adherence to prescribed oral medication in adult patients undergoing chronic hemodialysis: a critical review of the literature. Eur J Med Res 14(5):185–190PubMedPubMedCentral

Cedillo-Couvert EA, Ricardo AC, Chen J, Cohan J, Fischer MJ, Krousel-Wood M et al (2018) Self-reported medication adherence and CKD progression. Kidney Int Rep 3(3):645–651PubMedPubMedCentral

Sontakke S, Budania R, Bajait C, Jaiswal K, Pimpalkhute S (2015) Evaluation of adherence to therapy in patients of chronic kidney disease. Indian J Pharmacol 47(6):668–671PubMedPubMedCentral

10.

Tangkiatkumjai M, Walker DM, Praditpornsilpa K, Boardman H (2017) Association between medication adherence and clinical outcomes in patients with chronic kidney disease: a prospective cohort study. Clin Exp Nephrol 21(3):504–512PubMed

11.

Goh H, Kwan YH, Seah Y, Low LL, Fong W, Thumboo J (2017) A systematic review of the barriers affecting medication adherence in patients with rheumatic diseases. Rheumatol Int 37(10):1619–1628PubMed

12.

National Heart LaBI (2018) Quality assessment tool for observational cohort and cross-sectional studies 2018 https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools.

13.

Critical Appraisal Skills Programme (2018) CASP qualitative checklist 2018. https://casp-uk.net/wp-content/uploads/2018/03/CASP-Qualitative-Checklist-2018_fillable_form.pdf.

14.

Burkhart PV, Sabate E (2003) Adherence to long-term therapies: evidence for action. J Nurs Scholarsh 35(3):207PubMed

15.

Schmitt KE, Edie CF, Laflam P, Simbartl LA, Thakar CV (2010) Adherence to antihypertensive agents and blood pressure control in chronic kidney disease. Am J Nephrol 32(6):541–548PubMed

16.

Magacho EJ, Ribeiro LC, Chaoubah A, Bastos MG (2011) Adherence to drug therapy in kidney disease. Braz J Med Biol Res 44(3):258–262PubMed

17.

McKillop G, Joy J (2013) Patients’ experience and perceptions of polypharmacy in chronic kidney disease and its impact on adherent behaviour. J Ren Care 39(4):200–207PubMed

18.

Curtin RB, Walters BA, Schatell D, Pennell P, Wise M, Klicko K (2008) Self-efficacy and self-management behaviors in patients with chronic kidney disease. Adv Chronic Kidney Dis 15(2):191–205PubMed

19.

Muntner P, Judd SE, Krousel-Wood M, McClellan WM, Safford MM (2010) Low medication adherence and hypertension control among adults with CKD: data from the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study. Am J Kidney Dis 56(3):447–457PubMedPubMedCentral

20.

Hong K, Muntner P, Kronish I, Shilane D, Chang TI (2016) Medication adherence and visit-to-visit variability of systolic blood pressure in African Americans with chronic kidney disease in the AASK trial. J Hum Hypertens 30(1):73–78PubMed

21.

Molnar MZ, Gosmanova EO, Sumida K, Potukuchi PK, Lu JL, Jing J et al (2016) Predialysis cardiovascular disease medication adherence and mortality after transition to dialysis. Am J Kidney Dis 68(4):609–618PubMedPubMedCentral

22.

Truong VT, Moisan J, Kroger E, Langlois S, Gregoire JP (2016) Persistence and compliance with newly initiated antihypertensive drug treatment in patients with chronic kidney disease. Patient Prefer Adher 10:1121–1129

23.

Tesfaye WH, McKercher C, Peterson GM, Castelino RL, Jose M, Zaidi STR et al (2020) Medication adherence, burden and health-related quality of life in adults with predialysis chronic kidney disease: a prospective cohort study. Int J Environ Res Public Health 17(1):371PubMedCentral

24.

Kefale B, Tadesse Y, Alebachew M, Engidawork E (2018) Management practice, and adherence and its contributing factors among patients with chronic kidney disease at Tikur Anbessa Specialized Hospital: a hospital-based cross-sectional study. PLoS ONE 13(7):e0200415PubMedPubMedCentral

25.

Williams AF, Manias E, Walker R (2008) Adherence to multiple, prescribed medications in diabetic kidney disease: a qualitative study of consumers’ and health professionals’ perspectives. Int J Nurs Stud 45(12):1742–1756PubMed

26.

Bowling CB, Vandenberg AE, Phillips LS, McClellan WM, Johnson TM 2nd, Echt KV (2017) Older patients’ perspectives on managing complexity in CKD self-management. Clin J Am Soc Nephrol 12(4):635–643PubMedPubMedCentral

27.

Walker R, James H, Burns A (2012) Adhering to behaviour change in older pre-dialysis populations—what do patients think? A qualitative study. J Ren Care 38(1):34–42PubMed

28.

Salini A, Sajeeth C (2013) Prevalence, risk factors, adherence and non adherence in patient with chronic kidney disease: a prospective study. IJRPC 3(2):2231–2781

29.

Njeri LW, Ogallo WO, Nyamu DG, Opanga SA, Birichi AR (2018) Medication-related problems among adult chronic kidney disease patients in a sub-Saharan tertiary hospital. Int J Clin Pharm 40(5):1217–1224PubMed

30.

Ghimire S, Castelino RL, Lioufas NM, Peterson GM, Zaidi ST (2015) Nonadherence to medication therapy in haemodialysis patients: a systematic review. PLoS ONE 10(12):e0144119PubMedPubMedCentral

31.

McQuaid EL, Landier W (2018) Cultural issues in medication adherence: disparities and directions. J Gen Intern Med 33(2):200–206PubMed

32.

Frass M, Strassl RP, Friehs H, Müllner M, Kundi M, Kaye AD (2012) Use and acceptance of complementary and alternative medicine among the general population and medical personnel: a systematic review. Ochsner J 12(1):45–56PubMedPubMedCentral

33.

Seng JJB, Tan YLC, Lim RW, Ng HTS, Lee PH, Wong J (2018) Prevalence and risk factors for hypercalcemia among non-dialysis patients with chronic kidney disease-mineral and bone disorder. Int Urol Nephrol 50(10):1871–1877PubMed

34.

Virani SA, Khosla A, Levin A (2008) Chronic kidney disease, heart failure and anemia. Can J Cardiol 24:22B–B24PubMedPubMedCentral

35.

Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, McCann L et al (2018) Diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder: synopsis of the kidney disease: improving global outcomes 2017 clinical practice guideline update. Ann Intern Med 168(6):422–430PubMed

36.

Chiu YW, Teitelbaum I, Misra M, de Leon EM, Adzize T, Mehrotra R (2009) Pill burden, adherence, hyperphosphatemia, and quality of life in maintenance dialysis patients. Clin J Am Soc Nephrol 4(6):1089–1096PubMedPubMedCentral

37.

Jimmy B, Jose J (2011) Patient medication adherence: measures in daily practice. Oman Med J 26(3):155–159PubMedPubMedCentral

38.

Lam WY, Fresco P (2015) Medication adherence measures: an overview. Biomed Res Int 2015:217047PubMedPubMedCentral

39.

Liu H, Golin CE, Miller LG, Hays RD, Beck CK, Sanandaji S et al (2001) A comparison study of multiple measures of adherence to HIV protease inhibitors. Ann Intern Med 134(10):968–977PubMed

40.

Parker K, Nikam M, Jayanti A, Mitra S (2014) Medication burden in CKD-5D: impact of dialysis modality and setting. Clin Kidney J 7(6):557–561PubMedPubMedCentral

41.

Palmer S, Vecchio M, Craig JC, Tonelli M, Johnson DW, Nicolucci A et al (2013) Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies. Kidney Int 84(1):179–191PubMed

42.

Anderson RJ, Freedland KE, Clouse RE, Lustman PJ (2001) The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care 24(6):1069–1078PubMed

43.

Jiang W, Alexander J, Christopher E, Kuchibhatla M, Gaulden LH, Cuffe MS et al (2001) Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure. Arch Intern Med 161(15):1849–1856PubMed

44.

Hedayati SS, Minhajuddin AT, Toto RD, Morris DW, Rush AJ (2009) Prevalence of major depressive episode in CKD. Am J Kidney Dis 54(3):424–432PubMedPubMedCentral

45.

Long JM, Kee CC, Graham MV, Saethang TB, Dames FD (1998) Medication compliance and the older hemodialysis patient. Anna J 25(1):43–49 (Discussion 50-2) PubMed

46.

Raji MA, Kuo YF, Salazar JA, Satish S, Goodwin JS (2004) Ethnic differences in antihypertensive medication use in the elderly. Ann Pharmacother 38(2):209–214PubMed

47.

Kuo YF, Raji MA, Markides KS, Ray LA, Espino DV, Goodwin JS (2003) Inconsistent use of diabetes medications, diabetes complications, and mortality in older mexican americans over a 7-year period: data from the Hispanic established population for the epidemiologic study of the elderly. Diabetes Care 26(11):3054–3060PubMed

48.

Griva K, Lai AY, Lim HA, Yu Z, Foo MW, Newman SP (2014) Non-adherence in patients on peritoneal dialysis: a systematic review. PLoS ONE 9(2):e89001PubMedPubMedCentral

49.

Cintra FA, Guariento ME, Miyasaki LA (2010) Medicine adhesion in eldery people in an ambulatorial attendance. Cien Saude Colet 15(Suppl 3):3507–3515PubMed

50.

Mechta Nielsen T, Frøjk Juhl M, Feldt-Rasmussen B, Thomsen T (2018) Adherence to medication in patients with chronic kidney disease: a systematic review of qualitative research. Clin Kidney J 11(4):513–527PubMed

51.

Bailie GR, Eisele G, Liu L, Roys E, Kiser M, Finkelstein F et al (2005) Patterns of medication use in the RRI-CKD study: focus on medications with cardiovascular effects. Nephrol Dial Transplant 20(6):1110–1115PubMed

52.

Scott IA, Hilmer SN, Reeve E, Potter K, Le Couteur D, Rigby D et al (2015) Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Intern Med 175(5):827–834PubMed

53.

Reeve E, Shakib S, Hendrix I, Roberts MS, Wiese MD (2014) The benefits and harms of deprescribing. Med J Aust 201(7):386–389PubMed

54.

Fuertes JN, Mislowack A, Bennett J, Paul L, Gilbert TC, Fontan G et al (2007) The physician-patient working alliance. Patient Educ Couns 66(1):29–36PubMed

55.

Chewning B, Bylund CL, Shah B, Arora NK, Gueguen JA, Makoul G (2012) Patient preferences for shared decisions: a systematic review. Patient Educ Couns 86(1):9–18PubMed

56.

Silva SMd, Braido NF, Ottaviani AC, Gesualdo GD, Zazzetta MS, Orlandi FdS (2016) Social support of adults and elderly with chronic kidney disease on dialysis. Revista latino-americana de enfermagem 24:e2752PubMedPubMedCentral

57.

Cohen SD (2013) Social support interventions will improve the quality of life of ESRD patients. Semin Dial 26(3):262–265PubMed

58.

Lintonen TP, Konu AI, Seedhouse D (2007) Information technology in health promotion. Health Educ Res 23(3):560–566PubMed

59.

Baker L, Wagner TH, Singer S, Bundorf MK (2003) Use of the Internet and e-mail for health care information: results from a national survey. JAMA 289(18):2400–2406PubMed

60.

Weaver JB, Thompson NJ, Weaver SS, Hopkins GL (2009) Healthcare non-adherence decisions and internet health information. Comput Hum Behav 25(6):1373–1380

61.

Hsu KL, Fink JC, Ginsberg JS, Yoffe M, Zhan M, Fink W et al (2015) Self-reported medication adherence and adverse patient safety events in CKD. Am J Kidney Dis 66(4):621–629PubMedPubMedCentral

Titel: Factors affecting medication adherence among pre-dialysis chronic kidney disease patients: a systematic review and meta-analysis of literature
verfasst von: Jun Jie Benjamin Seng
Jia Ying Tan
Cheng Teng Yeam
Htay Htay
Wai Yin Marjorie Foo
Publikationsdatum: 31.03.2020
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 5/2020
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-020-02452-8

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Factors affecting medication adherence among pre-dialysis chronic kidney disease patients: a systematic review and meta-analysis of literature

Abstract

Background

Methods

Results

Conclusion

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

15% bedauern gewählte Blasenkrebs-Therapie

Costims – das nächste heiße Ding in der Krebstherapie?

Update Innere Medizin

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Background

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2020

Kidney transplantation improves arterial stiffness in patients with end-stage renal disease

The influence of cardiac valvular calcification on all-cause and cardiovascular mortality in maintenance hemodialysis patients

Living-donor kidney transplantation: comparison of sequential and simultaneous surgical organizations

Effects of an Omaha system-based continuing nursing program on nutritional status in patients undergoing peritoneal dialysis: a randomized controlled trial

Calciphylaxis: looking for clues beyond skin biopsy

The association of renal tubular inflammatory and injury markers with uric acid excretion in chronic kidney disease patients

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Erhebliches Risiko für Kehlkopfkrebs bei mäßiger Dysplasie

Nach Herzinfarkt mit Typ-1-Diabetes schlechtere Karten als mit Typ 2?

15% bedauern gewählte Blasenkrebs-Therapie

Costims – das nächste heiße Ding in der Krebstherapie?

Update Innere Medizin