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Combinatorial Determination of Ischemia Modified Albumin and Protein Carbonyl in the Diagnosis of NonST-Elevation Myocardial Infarction

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Abstract

Ischemia modified albumin (IMA) and Protein Carbonyl (PC) have known as proteins that are modified on the similar basis of oxidative stress induced protein modification and may have diagnostic potential in acute myocardial infarction. This study aims to evaluate the ability of using IMA and PC content to diagnose Non-ST elevation myocardial infarction (NSTEMI) and efficiency of combining these two markers. Serum from NSTEMI and healthy control were determined for serum IMA and PC content. The results showed that both of serum IMA level and PC content in NSTEMI was significantly higher than that of healthy controls. However, the PC content showed greater diagnostic performance than IMA. Combinatorial determination of serum IMA level with PC content level was enhanced test efficiency. In conclusion, our finding demonstrated that IMA and PC content can be used as a diagnostic marker for NSTEMI.

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Acknowledgment

This work was supported by Naresuan University Research Fund (R2553C076) and Faculty of Allied Health Science Postgraduate Research Studentship for Kritsanee Maneewong.

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Authors and Affiliations

  1. Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, 65000, Thailand

    Kritsanee Maneewong & Sarawut Kumphune

  2. Department of Cardiac Thoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, 65000, Thailand

    Titiporn Mekrungruangwong

  3. Department of Physical Therapy, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, 65000, Thailand

    Saowanee Luangaram

  4. Department of Medicine, Buddhachinaraj Hospital, Phitsanulok, 65000, Thailand

    Tomon Thongsri

Authors
  1. Kritsanee Maneewong
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  2. Titiporn Mekrungruangwong
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  3. Saowanee Luangaram
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  4. Tomon Thongsri
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  5. Sarawut Kumphune
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Correspondence to Sarawut Kumphune.

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Maneewong, K., Mekrungruangwong, T., Luangaram, S. et al. Combinatorial Determination of Ischemia Modified Albumin and Protein Carbonyl in the Diagnosis of NonST-Elevation Myocardial Infarction. Ind J Clin Biochem 26, 389–395 (2011). https://doi.org/10.1007/s12291-011-0118-2

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  • DOI: https://doi.org/10.1007/s12291-011-0118-2

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