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Standardized Approach to the Treatment of Adult Soft Tissue Sarcoma of the Extremities

  • Chapter
Treatment of Bone and Soft Tissue Sarcomas

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 179))

Abstract

Soft tissue sarcomas are very rare tumors. Available data are based on only a few prospective randomized trials. Most studies are retrospective, reviewing the results of single institutions. Furthermore, universally accepted treatment protocols for adult patients are lacking. Several prognostic factors have been identified, including grading, tumor size and development of metastatic disease; however, the relevance of other important aspects in the treatment of patients with soft tissue sarcomas remains unknown or subject to controversy. The main issues concern: which surgical margin width is safe from an oncological perspective? Does local recurrence influence survival? Can systemic chemotherapy improve prognosis? Is radiotherapy necessary in every case? Should it be applied pre-, post- or intraoperatively? What is the value of assessing the response after neoadjuvant therapy? These topics are examined in this review.

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Authors and Affiliations

  1. Department of Surgery, University Hospital Basel, Spitalstr. 21, Basel, 4031, Switzerland

    Christoph Kettelhack

  2. Orthopaedic Oncology, Department of Orthopaedic Surgery, Ludwig-Maximilians-University Munich, Marchioninistr. 15, Munich, 81377, Germany

    Hans Roland Dürr

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  1. Per-Ulf Tunn
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  1. Leiter Department Tumororthopädie Klinik für Orthopädie und Orthopädische Rheumatologie, HELIOS-Klinikum Berlin, Schwanebecker Chaussee 50, Berlin, 13125

    Per-Ulf Tunn

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Tunn, PU., Kettelhack, C., Dürr, H.R. (2009). Standardized Approach to the Treatment of Adult Soft Tissue Sarcoma of the Extremities. In: Tunn, PU. (eds) Treatment of Bone and Soft Tissue Sarcomas. Recent Results in Cancer Research, vol 179. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77960-5_13

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