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Mitochondriopathien

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Therapie der Krankheiten im Kindes- und Jugendalter

Zusammenfassung

Eine Vielzahl dieser seltenen Erkrankungen ist zwar in der Zwischenzeit molekularbiologisch charakterisiert, die Therapiemöglichkeiten sind jedoch nach wie vor eingeschränkt. Die Ursachen hierfür liegen in:

- Der relativen Seltenheit der Erkrankungen,

- der Heterogenität von Geno- und Phänotyp,

- der Unvorhersagbarkeit des klinischen Verlaufs,

- dem undulierenden oder remittierenden Verlauf der Krankheiten,

- präexistierender, irreversibler Gewebeschädigung zum Zeitpunkt der Diagnose und/oder bei Therapiebeginn sowie im

- inadäquaten Follow up und fehlenden Langzeitevaluierungen.

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Authors and Affiliations

  1. Klinikum Schwabing, StKM GmbH, Klinik für Kinder- und Jugendmedizin, Technische Universität München, Kölner Platz 1, 80804, München, Deutschland

    Peter Freisinger Prof. Dr. med.

  2. Universitätsklinik und Poliklinik für Kinder- und Jugendmedizin, Paracelsus Medizinische Privatuniversität, Müllner Hauptstr. 46, 5020, Salzburg, Österreich

    Wolfgang Sperl Prof. Dr. med.

Authors
  1. Wolfgang Sperl Prof. Dr. med.
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  2. Peter Freisinger Prof. Dr. med.
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Editor information

Editors and Affiliations

  1. Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital, Klinikum der Universität München, Lindwurmstr. 4, 80337, München, Deutschland

    Dietrich Reinhardt Prof. Dr. med. Dr. h. c.  & Thomas Nicolai Prof. Dr. med.  & 

  2. Zentrum für Kinder- und Jugendmedizin, Abt. Allgem. Pädiatrie und Neonatologie, Universitätsklinikum Gießen und Marburg, Standort Gießen, Feulgenstr. 12, 35392, Gießen, Deutschland

    Klaus-Peter Zimmer Prof. Dr. med.

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Sperl, W., Freisinger, P. (2014). Mitochondriopathien. In: Reinhardt, D., Nicolai, T., Zimmer, KP. (eds) Therapie der Krankheiten im Kindes- und Jugendalter. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41814-3_18

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  • DOI: https://doi.org/10.1007/978-3-642-41814-3_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-41813-6

  • Online ISBN: 978-3-642-41814-3

  • eBook Packages: Medicine (German Language)

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