Abstract
The paper re-emphasizes that intesive prolonged anticancer chemotherapy containing alkylating agents or procarbazine or both produces a high-incidence of gonadal failure, particularly in males. This evidence has been documented mostly in patients with Hodgkin’s disease. On the contrary, effective combination regimens, such as ABVD, not including the above mentioned drugs induce a comparatively less and transient germ cell toxicity. In devising chemotherapy for potentially curable neoplastic diseases in young patients efforts should be made to avoid or minimize the potential risk of drug-induced gonadal failure.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Andrieu JM, Masson D, Fiet J, Gourmel B, Czyglik F, Bernard J (1981) La fertilité des jeunes hommes atteints de la maladie de Hodgkin avant et aprés chimiothérapie. Nouv Presse Med 10: 2085–2088
Bonadonna G (1982) Chemotherapy strategies to improve the control of Hodgkin’s: The Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res 42: 4309–4320
Bonadonna G, Santoro A (1982) Drug selection in the treatment of Hodgkin’s disease. Haematol Oncol 1: 3–12
Bonadonna G, Valagussa P, De Palo GM (1981) The results of adjuvant chemotherapy in breast cancer are predominantly due to the hormonal change such therapy induces: the view against. In: Van Scoy-Mosher MB (ed) Controversies in medical oncology. Hall KG, Boston, pp 100–109
Chapman RM (1979) Cyclical combination chemotherapy and gonadal function. Lancet 1: 285–289
Chapman RM, Sutcliffe SB (1981) Protection of ovarian function by oral contraceptives in women receiving chemotherapy for Hodgkin’s disease. Blood 58: 849–851
Chapman RM, Sutcliffe SB, Malpas JS (1979) Cytotoxic-induced ovarian failure in women with Hodgkin’s disease: I Hormone function. JAMA 242: 1877–1881
De Vita VT (1981) The consequences of the chemotherapy of Hodgkin’s disease: The 10th David A. Karnofsky Memorial Lecture. Cancer 47: 1–13
Glode LM, Robinson J, Gould SF (1981) Protection from cyclophosphamide-induced testicular damage with an analogue of gonadotrophin-releasing hormone. Lancet 1: 1132–1134
Horning SJ, Hoppe RT, Kaplan HS, Rosenberg SA (1981) Female reproductive potential after treatment for Hodgkin’s disease. N Engl J Med 304: 1377–1382
Perry MC (ed) (1982) Toxicity of chemotherapy. Semin Oncol 9: 1–149
Shamberger RC, Rosenberg SA, Seipp CA, Sherins RJ (1981) Effect of high-dose methotrexate and vincristine on ovarian and testicular functions in patients undergoing postoperative adjuvant treatment of osteosarcoma. Cancer Treat Rep 65: 739–746
Schilsky RL, Sherins RJ, Hubbard SM, Wesley MN, Young RC, De Vita VT (1981) Long-term follow-up of ovarian function in women treated with MOPP chemotherapy for Hodgkin’s disease. Am J Med 71: 552–556
Sherins RJ, De Vita VT (1973) Effects of drug treatment for lymphoma on male reproductive capacity. Ann Intern Med 79: 216–220
Vigersky RA, Chapman RM, Berenberg J, Glass AR (1982) Testicular dysfunction in untreated Hodgkin’s disease. JAMA 73: 482–486
Waxman JHX, Terry YA, Wrigley PFM, Malpas JS, Rees LH, Besser GM, Lister TA (1982) Gonadal function in Hodgkin’s disease: long-term follow-up of chemotherapy. Br Med J 285:1612–1613
Whitehead E, Shalet SM, Blackledge G, Todd I, Crowther D, Beardwell CG (1982) The effects of Hodgkin’s disease and combination chemotherapy on gonadal function in the adult male. Cancer 49: 418–422
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer-Verlag
About this paper
Cite this paper
Bonadonna, G., Santoro, A., Viviani, S., Lombardi, C., Ragni, G. (1984). Gonadal Damage in Hodgkin’s Disease from Cancer Chemotherapeutic Regimens. In: Chambers, P.L., Preziosi, P., Chambers, C.M. (eds) Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals. Archives of Toxicology, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69132-4_16
Download citation
DOI: https://doi.org/10.1007/978-3-642-69132-4_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-12452-8
Online ISBN: 978-3-642-69132-4
eBook Packages: Springer Book Archive