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Effects of Early Serum Glucose Levels on Prognosis of Patients with Acute Intracerebral Hemorrhage

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Intracerebral Hemorrhage Research

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 111))

Abstract

Studies have indicated that hyperglycemia might cause cerebral damage to patients after acute intracerebral hemorrhage (ICH). But systematic studies on the effects of diabetes, stress hyperglycemia and normal serum glucose level on the prognosis of ICH patients are insufficient. It is essential to explore the prognosis among them. According to their serum glucose level within 24 h, 189 patients with ICH were divided into three groups: diabetes (group A), stress hyperglycemia (group B) and normal serum glucose (group C). The activity of daily living ability of patients was evaluated by Barthel index at 30 days after admission. The data analysis was done using cumulative logit model and rank sum test. Significant differences were observed in prognosis between group A and group C (OR: 0.056; CI: 0.022–0.143; p < 0.0001), B and C (OR: 0.081; CI: 0.039–0.167; p < 0.0001), respectively; there was no significant difference between A and B (p > 0.05). No difference was found between A and B in the early serum glucose level, but significant differences were observed between A and C, and between B and C. Early hyperglycemia may worsen the prognosis of ICH patients, though patients with diabetes or stress hyperglycemia after ICH may have similar outcomes when early serum glucose levels fluctuate within the same range.

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References

  1. Dennis MS, Burn JP, Sandercock PA, Bamford JM, Wade DT, Warlow CP (1993) Long-term survival after first-ever stroke: the Oxfordshire Community Stroke Project. Stroke 24(6):796–800

    PubMed  CAS  Google Scholar 

  2. Fewel ME, Thompson G Jr, Hoff JT (2003) Spontaneous intracerebral hemorrhage: a review. Neurosurg Focus 15(4):E1

    PubMed  Google Scholar 

  3. Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF (2001) Spontaneous intracerebral hemorrhage. N Engl J Med 344(19):1450–1460

    Article  PubMed  CAS  Google Scholar 

  4. Levetan CS (2004) Effect of hyperglycemia on stroke outcomes. Endocr Pract 10(supply 2):34–39

    PubMed  Google Scholar 

  5. Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC (2001) Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients. Stroke 32(10):2426–2432

    Article  PubMed  CAS  Google Scholar 

  6. Fuller JH, Shipley MJ, Rose G, Jarrett RJ, Keen H (1983) Mortality from coronary heart disease and stroke in relation to degree of glycaemia: the Whitehall study. Br Med J 287:867–870, Clin Res Ed). J (6393)

    Article  CAS  Google Scholar 

  7. Stamler J, Vaccaro O, Neaton JD, Wentworth D (1993) Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the multiple risk factor intervention trial. Diab Care 16(2):434–444

    Article  CAS  Google Scholar 

  8. Wolf PA, D’Agostino RB, Belanger AJ, Kannel WB (1991) Probability of stroke: a risk profile from the Framingham study. Stroke 22(3):312–318

    PubMed  CAS  Google Scholar 

  9. Ariesen MJ, Claus SP, Rinkel GJ, Algra A (2003) Risk factors for intracerebral hemorrhage in general population: a systematic review. Stroke 34(8):2060–2065

    Article  PubMed  CAS  Google Scholar 

  10. Kazui S, Minematsu K, Yamamoto H, Sawada T, Yamaguchi T (1997) Predisposing factors to enlargement of spontaneous intracerebral hematoma. Stroke 28(12):2370–2375

    PubMed  CAS  Google Scholar 

  11. Kothari RU, Brott T, Broderick JP, Barsan WG, Sauerbeck LR, Zuccarello M, Khoury J (1996) The ABCs of measuring intracerebral hemorrhage volumes. Stroke 27(8):1304–1305

    PubMed  CAS  Google Scholar 

  12. Garcia MJ, McNamara PM, Gordon T, Kannel WB (1974) Morbidity and mortality in diabetics in the Framingham population. Diabetes 23(2):1105–1112

    Google Scholar 

  13. Kessler II (1971) Mortality experience of diabetic patients. A twenty-six-year follow-up study. Am J Med 51(6):715–724

    Article  PubMed  CAS  Google Scholar 

  14. Lehto S, Ronnemaa T, Pyorala K, Laakso M (1996) Predictors of stroke in middle-aged patients with non-insulin-dependent diabetes. Stroke 27(1):63–68

    PubMed  CAS  Google Scholar 

  15. Clement S, Braithwaite SS, Magee MF, Ahmann A, Smith EP, Schafer RG, Hirsch IB (2004) American Diabetes Association Diabetes in Hospitals Writing Committee (2004) Management of diabetes and hyperglycemia in hospitals. Diab Care 27(2):553–591

    Article  Google Scholar 

  16. Okada S, Shikatak MM, Ogawa D, Usui H, Kido Y, Nagase R, Wada J, Shikata Y, Makino H (2003) Intercellular adhesion molecule deficient mice are resistant against renal injury after induction of diabetes. Diabetes 52(10):2586–2588

    Article  PubMed  CAS  Google Scholar 

  17. Chavakis T, Bierhaus A, Nawroth PP (2004) PRAGE(receptor for advanced glycation end products):a central player in the inflammatory response. Microbes Infect 6(13):1219–1225

    Article  PubMed  CAS  Google Scholar 

  18. Basta G, Schmidt AM, De Caterina R (2004) Advanced glycation end products and vascular inflammation; implications for accelerated atherosclerosis in diabetes. Cardiovasc Res 63(4):582–592

    Article  PubMed  CAS  Google Scholar 

  19. Levine SR, Welch KM, Helpern JA, Chopp M, Bruce R, Selwa J, Smith MB (1988) Prolonged deterioration of ischemic brain energy metabolism and acidosis associated with hyperglycemia: human cerebral infarction studied by serial 31P NMR spectroscopy. Ann Neurol 23(4):416–418

    Article  PubMed  CAS  Google Scholar 

  20. Song EC, Chu K, Jeong SW, Jung KH, Kim SH, Kim M, Yoon BW (2003) Hyperglycemia exacerbates brain edema and perihematomal cell death after intracerebral hemorrhage. Stroke 34(9):2215–2220

    Article  PubMed  CAS  Google Scholar 

  21. Lindsberg PJ, Roine RO (2004) Hyperglycemia in acute stroke. Stroke 35(2):363–364

    Article  PubMed  Google Scholar 

  22. Dietrich WD, Alonso O, Busto R (1993) Moderate hyperglycemia worsens acute blood-brain barrier injury after forebrain ischemia in rats. Stroke 24(1):111–116

    PubMed  CAS  Google Scholar 

  23. De Courten-Myers GM, Kleinholz M, Holm P, DeVoe G, Schmitt G, Wagner KR, Myers RE (1992) Hemorrhagic infarct conversion in experimental stroke. Ann Emerg Med 21(2):120–126

    Article  PubMed  Google Scholar 

  24. Laird AM, Miller PR, Kilgo PD, Meredith JW, Chang MC (2004) Relationship of early hyperglycemia to mortality in trauma patients. J Trauma 56(5):1058–1062

    Article  PubMed  Google Scholar 

  25. Young B, Ott L, Dempsey R, Haack D, Tibbs P (1989) Relationship between admission hyperglycemia and neurologic outcome of severely brain-injured patients. Ann Surg 210(4):466–473

    Article  PubMed  CAS  Google Scholar 

  26. Lange MP, Dahn MS, Jacobs LA (1985) The significance of hyperglycemia after injury. Heart Lung 14(5):470–472

    PubMed  CAS  Google Scholar 

  27. Coutinho M, Gerstein HC, Wang Y, Yusuf S (1999) The relationship between glucose and incident cardiovascular events: a meta regression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diab Care 22(2):233–240

    Article  CAS  Google Scholar 

  28. Efron D, South M, Volpe JJ, Inder T (2003) Crebral injury in association with profound iatrogenic hyperglycemia in a neonate. Eur J Paediatr Neurol 7(4):167–171

    Article  PubMed  Google Scholar 

  29. Van den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P (2003) Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycolic control. Crit Care Med 31(2):359–366

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

    Yanyue Wang, Tianzhu Wang & Xinyue Qin

  2. Department of Physiology and Pharmacology, Department of Neurosurgery, Department of Anesthesiology, Loma Linda University, School of Medicine, Loma Linda, CA, USA

    John H. Zhang

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  1. Yanyue Wang
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  2. Tianzhu Wang
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  3. John H. Zhang
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  4. Xinyue Qin
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Correspondence to Xinyue Qin .

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Editors and Affiliations

  1. , Neurosurgery, Physiology, Loma Linda University, Campus Street 11041, Loma Linda, 92530, USA

    John Zhang

  2. School of Medicine, Dept. Neurosurgery, Loma Linda University, Anderson St. 11234, Loma Linda, 92354, California, USA

    Austin Colohan

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Wang, Y., Wang, T., Zhang, J.H., Qin, X. (2011). Effects of Early Serum Glucose Levels on Prognosis of Patients with Acute Intracerebral Hemorrhage. In: Zhang, J., Colohan, A. (eds) Intracerebral Hemorrhage Research. Acta Neurochirurgica Supplementum, vol 111. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0693-8_67

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  • DOI: https://doi.org/10.1007/978-3-7091-0693-8_67

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-0692-1

  • Online ISBN: 978-3-7091-0693-8

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