Summary
To determine whether hyperaminoacidaemia may modify insulin-mediated glucose disposal, normal subjects were studied with the euglycaemic glucose-clamp technique, with or without an amino acid infusion, at a rate sufficient to duplicate the plasma concentration of most amino acids. Steady-state glucose infusion rates to maintain euglycaemia were 36% lower during hyperaminoacidaemia (7.3±1.0 versus 11.4±0.8mg· kg−1· min−1, p<0.01) at comparable insulin concentrations (92±6 versus 93±7 mU/l respectively). Thus, under conditions of hyperinsulinaemia, amino acids could compete with glucose as metabolic fuels.
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Tessari, P., Inchiostro, S., Biolo, G. et al. Hyperaminoacidaemia reduces insulin-mediated glucose disposal in healthy man. Diabetologia 28, 870–872 (1985). https://doi.org/10.1007/BF00291080
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DOI: https://doi.org/10.1007/BF00291080