Skip to main content
Erschienen in: Der Unfallchirurg 2/2007

01.02.2007 | CME - Weiterbildung • Zertifizierte Fortbildung

Chirurgisches Management von Wirbelsäulenmetastasen

verfasst von: PD Dr. K.-D. Schaser, I. Melcher, T. Mittlmeier, A. Schulz, J.H. Seemann, N.P. Haas, A.C. Disch

Erschienen in: Die Unfallchirurgie | Ausgabe 2/2007

Einloggen, um Zugang zu erhalten

Zusammenfassung

Die Wirbelsäule ist die Hauptlokalisation von Skelettmetastasen. Diese sind die häufigsten malignen Läsionen der Wirbelsäule und Anzeichen eines disseminierten Tumorleidens. In Abhängigkeit von primärer Tumorbiologie, Prognose der Überlebenszeit, Vorliegen sensomotorischer Defizite, spinaler Instabilität und Gesamtzustand des Patienten muss eine onkologisch sinnvolle und patientengerechte Wahl des therapeutischen Verfahrens erfolgen. Die Etablierung ventraler und erweiterter dorsaler Zugänge und Resektionen sowie neuer Stabilisierungstechniken hat die Grenze zugunsten eines Wandels von konservativen Methoden zur primär chirurgischen Intervention verschoben. Verschiedene valide, prognostische Scores können als Basis für die Differenzialindikation zu verschiedenen chirurgischen Therapieverfahren herangezogen werden und eine individuelle Entscheidungsfindung erleichtern. Indikationen für chirurgisches Vorgehen bestehen bei einer Überlebensprognose von mindestens 3 Monaten, unbeherrschbaren Schmerzen, Progress spinaler Kompression, neurologischer Befundverschlechterung unter Radiochemotherapie, spinaler Instabilität und notwendiger histologischer Befundsicherung.
Literatur
1.
Zurück zum Zitat Aaronson NK, Acquadro C, Alonso J et al. (1992) International Quality of Life Assessment (IQOLA) Project. Qual Life Res 1: 349–351CrossRefPubMed Aaronson NK, Acquadro C, Alonso J et al. (1992) International Quality of Life Assessment (IQOLA) Project. Qual Life Res 1: 349–351CrossRefPubMed
2.
Zurück zum Zitat Abrams HL, Spiro R, Goldstein N (1950) Metastases in carcinoma; analysis of 1000 autopsied cases. Cancer 3: 74–85CrossRefPubMed Abrams HL, Spiro R, Goldstein N (1950) Metastases in carcinoma; analysis of 1000 autopsied cases. Cancer 3: 74–85CrossRefPubMed
3.
Zurück zum Zitat Aebi M (2003) Spinal metastasis in the elderly. Eur Spine J 12: 202–213CrossRef Aebi M (2003) Spinal metastasis in the elderly. Eur Spine J 12: 202–213CrossRef
4.
Zurück zum Zitat Akeyson E (1996) Single-stage posterior vertebrectomy and replacement combined with posterior instrumentation for spinal metastasis. J Neurosurgery 85: 211–220 Akeyson E (1996) Single-stage posterior vertebrectomy and replacement combined with posterior instrumentation for spinal metastasis. J Neurosurgery 85: 211–220
5.
Zurück zum Zitat Alonso J, Ferrer M, Gandek B et al. (2004) Health-related quality of life associated with chronic conditions in eight countries: results from the International Quality of Life Assessment (IQOLA) Project. Qual Life Res 13: 283–298CrossRefPubMed Alonso J, Ferrer M, Gandek B et al. (2004) Health-related quality of life associated with chronic conditions in eight countries: results from the International Quality of Life Assessment (IQOLA) Project. Qual Life Res 13: 283–298CrossRefPubMed
6.
Zurück zum Zitat Arguello F, Baggs RB, Duerst RE et al. (1990) Pathogenesis of vertebral metastasis and epidural spinal cord compression. Cancer 65: 98–106CrossRefPubMed Arguello F, Baggs RB, Duerst RE et al. (1990) Pathogenesis of vertebral metastasis and epidural spinal cord compression. Cancer 65: 98–106CrossRefPubMed
7.
Zurück zum Zitat Bach F LB, Rohde K et al. (1990) Metastatic spinal cord compression: occurence, symptoms, clinical presentations and prognosis in 398 patients with spinal cord compression. Acta Neurochir (Wien) 107: 37–43 Bach F LB, Rohde K et al. (1990) Metastatic spinal cord compression: occurence, symptoms, clinical presentations and prognosis in 398 patients with spinal cord compression. Acta Neurochir (Wien) 107: 37–43
8.
Zurück zum Zitat Barragan-Campos HM, Lo D, Cormier E et al. (2006) Percutaneous Vertebroplasty for Spinalmetastases: Complications. Radiology 238: 354–362PubMed Barragan-Campos HM, Lo D, Cormier E et al. (2006) Percutaneous Vertebroplasty for Spinalmetastases: Complications. Radiology 238: 354–362PubMed
9.
Zurück zum Zitat Barron KD, Hirano A, Araki S, Terry RD (1959) Experiences with metastatic neoplasms involving the spinal cord. Neurology 9: 91–106PubMed Barron KD, Hirano A, Araki S, Terry RD (1959) Experiences with metastatic neoplasms involving the spinal cord. Neurology 9: 91–106PubMed
10.
Zurück zum Zitat Bascoulergue Y, Leclercq R et al. (1988) Percutaneous injection of methyl methacrylat e in the vertebral body for the treatment of various diseases. Radiology 169: 372 (Abstr) Bascoulergue Y, Leclercq R et al. (1988) Percutaneous injection of methyl methacrylat e in the vertebral body for the treatment of various diseases. Radiology 169: 372 (Abstr)
11.
Zurück zum Zitat Berenson J (2002) Advances in the biology and treatment of myeloma bone disease. Semin Oncol 29: 11–16 Berenson J (2002) Advances in the biology and treatment of myeloma bone disease. Semin Oncol 29: 11–16
12.
Zurück zum Zitat Berkfeld J, Kirchner J, Heinrich T, Kollath J (1999) Hypervascular spinal tumors: Influence of the embolization technique on perioperative hemorrhage. Am J Neuroradiol 20: 757–763PubMed Berkfeld J, Kirchner J, Heinrich T, Kollath J (1999) Hypervascular spinal tumors: Influence of the embolization technique on perioperative hemorrhage. Am J Neuroradiol 20: 757–763PubMed
13.
Zurück zum Zitat Body JJ (2002) Bisphosphonatesfor cancer patients: why, how, and when? Support Care Cancer 10: 399–407CrossRefPubMed Body JJ (2002) Bisphosphonatesfor cancer patients: why, how, and when? Support Care Cancer 10: 399–407CrossRefPubMed
14.
Zurück zum Zitat Boogerd W, van der Sande JJ (1993) Diagnosis and treatment of spinal cord compression in malignant disease. Cancer Treat Rev 19: 129–150CrossRefPubMed Boogerd W, van der Sande JJ (1993) Diagnosis and treatment of spinal cord compression in malignant disease. Cancer Treat Rev 19: 129–150CrossRefPubMed
15.
Zurück zum Zitat Boriani S, De Iure F, Bertoni F et al. (1996) En bloc resections of bone tumors of the thoracolumbar spine. A preliminary report on 29 patients. Spine 21: 1927–1931CrossRefPubMed Boriani S, De Iure F, Bertoni F et al. (1996) En bloc resections of bone tumors of the thoracolumbar spine. A preliminary report on 29 patients. Spine 21: 1927–1931CrossRefPubMed
16.
Zurück zum Zitat Boriani S, Biagini R, DeIure F, Giunti A (2000) The use of the carbon-fiber reinforced modular implant for the reconstruction of the anterior column of the spine. A clinical and experimental study conducted in 42 cases. Chir Organi Mov 85: 309–335PubMed Boriani S, Biagini R, DeIure F, Giunti A (2000) The use of the carbon-fiber reinforced modular implant for the reconstruction of the anterior column of the spine. A clinical and experimental study conducted in 42 cases. Chir Organi Mov 85: 309–335PubMed
17.
Zurück zum Zitat Bridwell KH, Jenny AB, Saul T et al. (1988) Posterior segmental spinal instrumentation (PSSI) with posterolateral decompression and debulking for metastatic thoracic and lumbar spine disease. Limitations of the technique. Spine 13: 1383–1394CrossRefPubMed Bridwell KH, Jenny AB, Saul T et al. (1988) Posterior segmental spinal instrumentation (PSSI) with posterolateral decompression and debulking for metastatic thoracic and lumbar spine disease. Limitations of the technique. Spine 13: 1383–1394CrossRefPubMed
18.
Zurück zum Zitat Broaddus WC, Delashaw JB Jr, Ferguson RD, Jane JA (1990) Preoperative superselective arteriolar embolization: a new approach to enhance resectability of spinal tumors. Neurosurgery 27: 755–759CrossRefPubMed Broaddus WC, Delashaw JB Jr, Ferguson RD, Jane JA (1990) Preoperative superselective arteriolar embolization: a new approach to enhance resectability of spinal tumors. Neurosurgery 27: 755–759CrossRefPubMed
19.
Zurück zum Zitat Byrne TN (1992) Spinal cord compression from epidural metastases. N Engl J Med 327: 614–619PubMed Byrne TN (1992) Spinal cord compression from epidural metastases. N Engl J Med 327: 614–619PubMed
21.
Zurück zum Zitat Constans JP, de Divitiis E, Donzelli R et al. (1983) Spinal metastases with neurological manifestations. Review of 600 cases. J Neurosurg 59: 111–118PubMed Constans JP, de Divitiis E, Donzelli R et al. (1983) Spinal metastases with neurological manifestations. Review of 600 cases. J Neurosurg 59: 111–118PubMed
22.
Zurück zum Zitat Cooper PR, Errico TJ, Martin R et al. (1993) A systematic approach to spinal reconstruction after anterior decompression for neoplastic disease of the thoracic and lumbar spine. Neurosurgery 32: 1–8PubMed Cooper PR, Errico TJ, Martin R et al. (1993) A systematic approach to spinal reconstruction after anterior decompression for neoplastic disease of the thoracic and lumbar spine. Neurosurgery 32: 1–8PubMed
23.
Zurück zum Zitat Cortet B, Boutry N et al. (1997) Percutaneous vertebroplasty in patients with osteolytic metastases or multiple myeloma. Rev Rheum Engl Ed 64: 177–183 Cortet B, Boutry N et al. (1997) Percutaneous vertebroplasty in patients with osteolytic metastases or multiple myeloma. Rev Rheum Engl Ed 64: 177–183
24.
Zurück zum Zitat Cotten A, Corten B et al. (1996) Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow up. Radiology 200: 525–530PubMed Cotten A, Corten B et al. (1996) Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow up. Radiology 200: 525–530PubMed
25.
Zurück zum Zitat Cybulski GR, Von Roenn KA, D’Angelo CM, DeWald RL (1987) Luque rod stabilization for metastatic disease of the spine. Surg Neurol 28: 277–283CrossRefPubMed Cybulski GR, Von Roenn KA, D’Angelo CM, DeWald RL (1987) Luque rod stabilization for metastatic disease of the spine. Surg Neurol 28: 277–283CrossRefPubMed
26.
Zurück zum Zitat Delattre JY, Thaler HT et al. (1989) A dose response study of dexamethasone in a model of spinal cord compression caused by epidural tumor. J Neurosurgery 70: 920–925 Delattre JY, Thaler HT et al. (1989) A dose response study of dexamethasone in a model of spinal cord compression caused by epidural tumor. J Neurosurgery 70: 920–925
27.
Zurück zum Zitat Denis F (1984) Spinal instability as defined by the threee column spine-concept in acute spinal trauma. Clin Orthop 189: 65–76PubMed Denis F (1984) Spinal instability as defined by the threee column spine-concept in acute spinal trauma. Clin Orthop 189: 65–76PubMed
28.
Zurück zum Zitat Deramond H, Galibert P (1989) La vertebroplastie percutanee acrylique dans la traitement des hemangiomes vertebrauz agressifs. Rachis 1: 143–153 Deramond H, Galibert P (1989) La vertebroplastie percutanee acrylique dans la traitement des hemangiomes vertebrauz agressifs. Rachis 1: 143–153
29.
Zurück zum Zitat DeWald RL, Bridwell KH, Prodromas C, Rodts MF (1985) Reconstructive spinal surgery as palliation for metastatic malignancies of the spine. Spine 10: 21–26CrossRefPubMed DeWald RL, Bridwell KH, Prodromas C, Rodts MF (1985) Reconstructive spinal surgery as palliation for metastatic malignancies of the spine. Spine 10: 21–26CrossRefPubMed
31.
Zurück zum Zitat Dickman CA, Karahiolos DG et al. (1996) Thoracic vertebrectomy and reconstruction using a microsurgical thoracoscopic approach. Neurosurgery 38: 279–293CrossRefPubMed Dickman CA, Karahiolos DG et al. (1996) Thoracic vertebrectomy and reconstruction using a microsurgical thoracoscopic approach. Neurosurgery 38: 279–293CrossRefPubMed
32.
Zurück zum Zitat Domchek SM, Younger J, Finkelstein DM, Seiden MV (2000) Predictors of skeletal complications in patients with metastatic breast carcinoma. Cancer 89: 363–368CrossRefPubMed Domchek SM, Younger J, Finkelstein DM, Seiden MV (2000) Predictors of skeletal complications in patients with metastatic breast carcinoma. Cancer 89: 363–368CrossRefPubMed
33.
Zurück zum Zitat Ecker RD et al. (2005) Diagnosis and treatment of vertebral column metastases. Mayo Clin Proc 80: 1177–1186PubMed Ecker RD et al. (2005) Diagnosis and treatment of vertebral column metastases. Mayo Clin Proc 80: 1177–1186PubMed
34.
Zurück zum Zitat Enkaoua EA, Chatellier G et al. (1997) Vertebral metastases: a critical appreciation of the preoperative prognostic tokuhashi score in a series of 71 cases. Spine 22: 2293–2298CrossRefPubMed Enkaoua EA, Chatellier G et al. (1997) Vertebral metastases: a critical appreciation of the preoperative prognostic tokuhashi score in a series of 71 cases. Spine 22: 2293–2298CrossRefPubMed
35.
Zurück zum Zitat Enneking WF, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop 153: 106–112PubMed Enneking WF, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop 153: 106–112PubMed
36.
Zurück zum Zitat Ernstberger T, König F, Schultz W (2005) Expandable vertebral body replacement in patients with thoracolumbar spine tumors. Arch Orthop Trauma Surg 125: 660–669CrossRefPubMed Ernstberger T, König F, Schultz W (2005) Expandable vertebral body replacement in patients with thoracolumbar spine tumors. Arch Orthop Trauma Surg 125: 660–669CrossRefPubMed
37.
Zurück zum Zitat Finkelstein JA, Zaveri G, Wai E et al. (2003) A population-based study of surgery for spinal metastases. Survival rates and complications. J Bone Joint Surg Br 85: 1045–1050CrossRefPubMed Finkelstein JA, Zaveri G, Wai E et al. (2003) A population-based study of surgery for spinal metastases. Survival rates and complications. J Bone Joint Surg Br 85: 1045–1050CrossRefPubMed
38.
Zurück zum Zitat Fourney DR, Nader R et al. (2003) Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. J Neurosurgery 98: 21–30 Fourney DR, Nader R et al. (2003) Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. J Neurosurgery 98: 21–30
39.
Zurück zum Zitat Galasko CSB, Crank S (2000) Spinal instability secondary to metastatic cancer. J Bone Joint Surg 4: 570–576 Galasko CSB, Crank S (2000) Spinal instability secondary to metastatic cancer. J Bone Joint Surg 4: 570–576
40.
Zurück zum Zitat Ghogawala Z, Mansfield FL, Borges LF (2001) Spinal radiation before surgical decompression adversely affects outcomes of surgery for symptomatic metastatic spinal cord compression. Spine 26: 818–824CrossRefPubMed Ghogawala Z, Mansfield FL, Borges LF (2001) Spinal radiation before surgical decompression adversely affects outcomes of surgery for symptomatic metastatic spinal cord compression. Spine 26: 818–824CrossRefPubMed
41.
Zurück zum Zitat Gilbert RW, Kim JH, Posner JB (1978) Epidural spinal cord compression from metastatic tumor: diagnosis and treatment. Ann Neurol 3: 40–51CrossRefPubMed Gilbert RW, Kim JH, Posner JB (1978) Epidural spinal cord compression from metastatic tumor: diagnosis and treatment. Ann Neurol 3: 40–51CrossRefPubMed
42.
Zurück zum Zitat Gokoslan ZL YJ, Walsh GL et al. (1998) Transthoracic vertebrectomy for metastatic spinal tumors. J Neurosurg 89: 599–609PubMed Gokoslan ZL YJ, Walsh GL et al. (1998) Transthoracic vertebrectomy for metastatic spinal tumors. J Neurosurg 89: 599–609PubMed
43.
Zurück zum Zitat Guyer RD (1999) Perirectus retroperitoneal approach for anterior lumbar interbody fusion. In: Zdeblick T (ed) Anterior approaches to the spine. Quality Medical Publishing, Inc., St. Louis, Missouri, pp 203–217 Guyer RD (1999) Perirectus retroperitoneal approach for anterior lumbar interbody fusion. In: Zdeblick T (ed) Anterior approaches to the spine. Quality Medical Publishing, Inc., St. Louis, Missouri, pp 203–217
44.
45.
Zurück zum Zitat Harms J (1991) Screw-threaded rod system in spinal fusion surgery. Spine 6: 541–575 Harms J (1991) Screw-threaded rod system in spinal fusion surgery. Spine 6: 541–575
46.
Zurück zum Zitat Harrington KD (1988) Anterior decompression and stabilization of the spine as a treatment for vertebral collapse and spinal cord compression from metastatic malignancy. Clin Orthop Relat Res 233: 177–197PubMed Harrington KD (1988) Anterior decompression and stabilization of the spine as a treatment for vertebral collapse and spinal cord compression from metastatic malignancy. Clin Orthop Relat Res 233: 177–197PubMed
47.
Zurück zum Zitat Harrington KD (1997) Orthopedic surgical management of skeletal complications of malignancy. Cancer 80: 1614–1627CrossRefPubMed Harrington KD (1997) Orthopedic surgical management of skeletal complications of malignancy. Cancer 80: 1614–1627CrossRefPubMed
48.
Zurück zum Zitat Hatrick NC, Lucas JD, Timothy AR, Smith MA (2000) The surgical treatment of metastatic disease of the spine. Radiother Oncol 56: 335–339CrossRefPubMed Hatrick NC, Lucas JD, Timothy AR, Smith MA (2000) The surgical treatment of metastatic disease of the spine. Radiother Oncol 56: 335–339CrossRefPubMed
49.
Zurück zum Zitat Healey JH, Brown HK (2000) Complications of bone metastases: surgical management. Cancer 88: 2940–2951CrossRefPubMed Healey JH, Brown HK (2000) Complications of bone metastases: surgical management. Cancer 88: 2940–2951CrossRefPubMed
50.
Zurück zum Zitat Heary RF, Bono CM (2001) Metastatic spinal tumors. Neurosurg Focus 11: e1 Heary RF, Bono CM (2001) Metastatic spinal tumors. Neurosurg Focus 11: e1
51.
Zurück zum Zitat Hess T KB, Schmidt E et al. (1997) Use of preoperative vascular embolization in spinal metastasis resection. Arch Orthop Trauma Surg 116: 279–282PubMed Hess T KB, Schmidt E et al. (1997) Use of preoperative vascular embolization in spinal metastasis resection. Arch Orthop Trauma Surg 116: 279–282PubMed
52.
Zurück zum Zitat Hirabayashi H, Ebara S, Kinoshita T et al. (2003) Clinical outcome and survival after palliative surgery for spinal metastases: palliative surgery in spinal metastases. Cancer 97: 476–484CrossRefPubMed Hirabayashi H, Ebara S, Kinoshita T et al. (2003) Clinical outcome and survival after palliative surgery for spinal metastases: palliative surgery in spinal metastases. Cancer 97: 476–484CrossRefPubMed
53.
Zurück zum Zitat Holman PJ, Suki D, McCutcheon I et al. (2005) Surgical management of metastatic disease of the lumbar spine: experience with 139 patients. J Neurosurg Spine 2: 550–563PubMed Holman PJ, Suki D, McCutcheon I et al. (2005) Surgical management of metastatic disease of the lumbar spine: experience with 139 patients. J Neurosurg Spine 2: 550–563PubMed
54.
Zurück zum Zitat Hosono N, Ueda T, Tamura D et al. (2005) Prognostic relevance of clinical symptoms in patients with spinal metastases. Clin Orthop Relat Res 436: 196–201CrossRefPubMed Hosono N, Ueda T, Tamura D et al. (2005) Prognostic relevance of clinical symptoms in patients with spinal metastases. Clin Orthop Relat Res 436: 196–201CrossRefPubMed
55.
Zurück zum Zitat Jacobs WB PR (2001) Evaluation and treatment of spinal metastases: an overview. Neurosurg Focus 11: 1–11 Jacobs WB PR (2001) Evaluation and treatment of spinal metastases: an overview. Neurosurg Focus 11: 1–11
56.
Zurück zum Zitat Janjan NA (1996) Radiotherapeutic management of spinal metastases. J Pain Symptom Manage 11: 47–56CrossRefPubMed Janjan NA (1996) Radiotherapeutic management of spinal metastases. J Pain Symptom Manage 11: 47–56CrossRefPubMed
57.
Zurück zum Zitat Jansson KA, Bauer HC (2006) Survival, complications and outcome in 282 patients operated for neurological deficit due to thoracic or lumbar spinal metastases. Eur Spine J 15: 196–202CrossRefPubMed Jansson KA, Bauer HC (2006) Survival, complications and outcome in 282 patients operated for neurological deficit due to thoracic or lumbar spinal metastases. Eur Spine J 15: 196–202CrossRefPubMed
58.
Zurück zum Zitat Kang M, Gupta S, Khandelwal N et al. (1999) CT-guided fine-needle aspiration biopsy of spinal lesions. Acta Radiol 40: 474–478PubMed Kang M, Gupta S, Khandelwal N et al. (1999) CT-guided fine-needle aspiration biopsy of spinal lesions. Acta Radiol 40: 474–478PubMed
59.
Zurück zum Zitat Khan SN (2006) Surgical management of metastatic spinal tumors. Orthop Clin N Am 37: 99–104CrossRef Khan SN (2006) Surgical management of metastatic spinal tumors. Orthop Clin N Am 37: 99–104CrossRef
60.
61.
Zurück zum Zitat Klimo P, Kestle JRW, Schmidt MH (2005) A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease. Neuro-Oncology 7: 64–75 Klimo P, Kestle JRW, Schmidt MH (2005) A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease. Neuro-Oncology 7: 64–75
62.
Zurück zum Zitat Kornblum MB, Wesolowski DP, Fischgrund JS, Herkowitz HN (1998) Computed tomography-guided biopsy of the spine. A review of 103 patients. Spine 23: 81–85CrossRefPubMed Kornblum MB, Wesolowski DP, Fischgrund JS, Herkowitz HN (1998) Computed tomography-guided biopsy of the spine. A review of 103 patients. Spine 23: 81–85CrossRefPubMed
63.
Zurück zum Zitat Kostuik JP, Errico TJ, Gleason TF, Errico CC (1988) Spinal stabilization of vertebral column tumors. Spine 13: 250–256CrossRefPubMed Kostuik JP, Errico TJ, Gleason TF, Errico CC (1988) Spinal stabilization of vertebral column tumors. Spine 13: 250–256CrossRefPubMed
64.
Zurück zum Zitat Lee CK, Rosa R, Fernand R (1986) Surgical treatment of tumors of the spine. Spine 11: 201–208CrossRefPubMed Lee CK, Rosa R, Fernand R (1986) Surgical treatment of tumors of the spine. Spine 11: 201–208CrossRefPubMed
65.
Zurück zum Zitat Liebschner RW, Keaveny TM (2001) Effects of bone cement volume and distribution on vertebral stiffness after vertebroplasty. Spine 26: 1547–1554CrossRefPubMed Liebschner RW, Keaveny TM (2001) Effects of bone cement volume and distribution on vertebral stiffness after vertebroplasty. Spine 26: 1547–1554CrossRefPubMed
66.
Zurück zum Zitat Lin PP, Moura MF et al. (2002) Long-term follow-up of patients with giant cell tumor of the sacrum treated with selective arterial embolization. Cancer 95: 1317–1325CrossRefPubMed Lin PP, Moura MF et al. (2002) Long-term follow-up of patients with giant cell tumor of the sacrum treated with selective arterial embolization. Cancer 95: 1317–1325CrossRefPubMed
67.
Zurück zum Zitat Loblaw DA (1998) Emergency treatment of malignant extradural spinal cord compression: an evidence-based guideline. J Clin Oncol 16: 1613–1624PubMed Loblaw DA (1998) Emergency treatment of malignant extradural spinal cord compression: an evidence-based guideline. J Clin Oncol 16: 1613–1624PubMed
68.
Zurück zum Zitat Magerl F (1988) Total posterior vertebrectomy of the thoracic or lumbar spine. Clin Orthop 232: 62–69PubMed Magerl F (1988) Total posterior vertebrectomy of the thoracic or lumbar spine. Clin Orthop 232: 62–69PubMed
69.
Zurück zum Zitat Manke C, Lenhart M et al. (1996) Spinal metastases from renal cell carcinoma: effect of preoperative particle embolization on intraoperative blood loss. Am J Neuroradiol 22: 997–1003 Manke C, Lenhart M et al. (1996) Spinal metastases from renal cell carcinoma: effect of preoperative particle embolization on intraoperative blood loss. Am J Neuroradiol 22: 997–1003
70.
Zurück zum Zitat Mc Lain RF (1998) Endoscopically assisted decompression for metastatic thoracic neoplasms. Spine 23: 1130–1135CrossRefPubMed Mc Lain RF (1998) Endoscopically assisted decompression for metastatic thoracic neoplasms. Spine 23: 1130–1135CrossRefPubMed
71.
Zurück zum Zitat McDonnell MF, Glassman SD, Dimar JR 2nd et al. (1996) Perioperative complications of anterior procedures on the spine. J Bone Joint Surg Am 78: 839–847PubMed McDonnell MF, Glassman SD, Dimar JR 2nd et al. (1996) Perioperative complications of anterior procedures on the spine. J Bone Joint Surg Am 78: 839–847PubMed
72.
Zurück zum Zitat Menezes AH (1991) Anterior approaches to the craniocervical junction. Clin Neurosurg 37: 756–769PubMed Menezes AH (1991) Anterior approaches to the craniocervical junction. Clin Neurosurg 37: 756–769PubMed
73.
Zurück zum Zitat Merk H, Liebau C, Baltzer A et al. (2000) Implantation of a Harms titanium mesh cylinder for vertebral body replacement in spinal metastases. Z Orthop Grenzgeb 138: 169–173CrossRef Merk H, Liebau C, Baltzer A et al. (2000) Implantation of a Harms titanium mesh cylinder for vertebral body replacement in spinal metastases. Z Orthop Grenzgeb 138: 169–173CrossRef
74.
Zurück zum Zitat Neville-Webbe HL, Coleman RE (2002) The anti-tumor activity of bisphosphonates. Cancer Treat Rev 28: 305–319CrossRefPubMed Neville-Webbe HL, Coleman RE (2002) The anti-tumor activity of bisphosphonates. Cancer Treat Rev 28: 305–319CrossRefPubMed
75.
Zurück zum Zitat Nichols PG (1985) Evaluate posterior decompression by laminectomy for malignant tumors of the spine. Clin Orthop 201: 210PubMed Nichols PG (1985) Evaluate posterior decompression by laminectomy for malignant tumors of the spine. Clin Orthop 201: 210PubMed
76.
Zurück zum Zitat O’Rourke T, George CB, Redmond J 3rd et al. (1986) Spinal computed tomography and computed tomographic metrizamide myelography in the early diagnosis of metastatic disease. J Clin Oncol 4: 576–583PubMed O’Rourke T, George CB, Redmond J 3rd et al. (1986) Spinal computed tomography and computed tomographic metrizamide myelography in the early diagnosis of metastatic disease. J Clin Oncol 4: 576–583PubMed
77.
Zurück zum Zitat Olerud C, Lofberg AM, Lorelius LE, Sjostrom L (1993) Embolization of spinal metastasis reduces perioperative blood loss. 21patients operated on for renal cell carcinoma. Acta Orthop Scand 64: 9–12PubMed Olerud C, Lofberg AM, Lorelius LE, Sjostrom L (1993) Embolization of spinal metastasis reduces perioperative blood loss. 21patients operated on for renal cell carcinoma. Acta Orthop Scand 64: 9–12PubMed
78.
79.
Zurück zum Zitat Panjabi MM, Crisco JJ et al (1988) What constitutes spinal instability? Clin Neurosurg 34: 313–339PubMed Panjabi MM, Crisco JJ et al (1988) What constitutes spinal instability? Clin Neurosurg 34: 313–339PubMed
80.
Zurück zum Zitat Patchell RA, Regine WF, Saris S et al. (2005) Direct compressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet 366: 643–648CrossRefPubMed Patchell RA, Regine WF, Saris S et al. (2005) Direct compressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet 366: 643–648CrossRefPubMed
81.
Zurück zum Zitat Pavlakis N (2002) Bisphosphonates for breast cancer. Cochrane database Syst Rev: CD003474 Pavlakis N (2002) Bisphosphonates for breast cancer. Cochrane database Syst Rev: CD003474
82.
Zurück zum Zitat Phadke DM, Lucas DR, Madan S (2001) Fine-needle aspiration biopsy of vertebral and intervertebral disc lesions: specimen adequacy, diagnostic utility, and pitfalls. Arch Pathol Lab Med 125: 1463–1468PubMed Phadke DM, Lucas DR, Madan S (2001) Fine-needle aspiration biopsy of vertebral and intervertebral disc lesions: specimen adequacy, diagnostic utility, and pitfalls. Arch Pathol Lab Med 125: 1463–1468PubMed
83.
Zurück zum Zitat Phillips E, Levine AM (1989) Metastatic lesions of the upper cervical spine. Spine 14: 1071–1077CrossRefPubMed Phillips E, Levine AM (1989) Metastatic lesions of the upper cervical spine. Spine 14: 1071–1077CrossRefPubMed
84.
Zurück zum Zitat Pilitsis JG (2001) The role of vertebroplasty in metastatic spinal disease. Neurosurg Focus 6 (article 9): 1–4 Pilitsis JG (2001) The role of vertebroplasty in metastatic spinal disease. Neurosurg Focus 6 (article 9): 1–4
85.
Zurück zum Zitat Posner JB (1977) Management of central nervous system metastases. Semin Oncol 4: 81–91PubMed Posner JB (1977) Management of central nervous system metastases. Semin Oncol 4: 81–91PubMed
86.
Zurück zum Zitat Roscoe MW, St Lois E et al. (1989) Preoperative embolization in the treatment of osseous metastases from renal cell carcinoma. Clin Orthop 238: 302–307PubMed Roscoe MW, St Lois E et al. (1989) Preoperative embolization in the treatment of osseous metastases from renal cell carcinoma. Clin Orthop 238: 302–307PubMed
87.
Zurück zum Zitat Rosenthal D, Lorenz R et al. (1996) Anterior decompression and stabilization using microsurgical endoscopic technique for metastatic tumors of the thoracic spine. J Neurosurgery 84: 565–572 Rosenthal D, Lorenz R et al. (1996) Anterior decompression and stabilization using microsurgical endoscopic technique for metastatic tumors of the thoracic spine. J Neurosurgery 84: 565–572
88.
Zurück zum Zitat Roy-Camilles RSG (1981) Resections vertébrale totale dans la chirugie tumorale au niveau du rachis dorsal par voie postérieure pure: technique-indications. Rev Chir Orthop Reparatrice Appar Mot 67: 421–430PubMed Roy-Camilles RSG (1981) Resections vertébrale totale dans la chirugie tumorale au niveau du rachis dorsal par voie postérieure pure: technique-indications. Rev Chir Orthop Reparatrice Appar Mot 67: 421–430PubMed
89.
Zurück zum Zitat Ruff RL, Lanska DJ (1989) Epidural metastases in prospectively evaluated veterans with cancer and back pain. Cancer 63: 2234–2241PubMed Ruff RL, Lanska DJ (1989) Epidural metastases in prospectively evaluated veterans with cancer and back pain. Cancer 63: 2234–2241PubMed
90.
Zurück zum Zitat Ryken TC, Eichholz KM, Gerszten PC et al. (2003) Evidence-based review of the surgical management of vertebral column metastatic disease. Neurosurg Focus 15: E11 Ryken TC, Eichholz KM, Gerszten PC et al. (2003) Evidence-based review of the surgical management of vertebral column metastatic disease. Neurosurg Focus 15: E11
91.
Zurück zum Zitat San Millan Ruiz D, Hendrickson FR et al. (1999) Pathology findings with acrylic implants. Bone 25: 85–90CrossRefPubMed San Millan Ruiz D, Hendrickson FR et al. (1999) Pathology findings with acrylic implants. Bone 25: 85–90CrossRefPubMed
92.
Zurück zum Zitat Schaberg J, Gainor BJ (1985) A profile of metastatic carcinoma of the spine. Spine 10: 19–20CrossRefPubMed Schaberg J, Gainor BJ (1985) A profile of metastatic carcinoma of the spine. Spine 10: 19–20CrossRefPubMed
93.
Zurück zum Zitat Schirrmeister H, Glatting G, Hetzel J et al. (2001) Prospective evaluation of the clinical value of planar bone scans, SPECT, and (18)F-labeled NaF PET in newly diagnosed lung cancer. J Nucl Med 42: 1800–1804PubMed Schirrmeister H, Glatting G, Hetzel J et al. (2001) Prospective evaluation of the clinical value of planar bone scans, SPECT, and (18)F-labeled NaF PET in newly diagnosed lung cancer. J Nucl Med 42: 1800–1804PubMed
94.
Zurück zum Zitat Schoeggl A, Matula C (2002) Neurological outcome following laminectomy in spinal metastases. Spinal Cord 40: 363–366CrossRefPubMed Schoeggl A, Matula C (2002) Neurological outcome following laminectomy in spinal metastases. Spinal Cord 40: 363–366CrossRefPubMed
95.
Zurück zum Zitat Siegal T (1985) Surgical decompression of anterior and posterior malignant epidural tumors compressing the spinal cord: a prospective study. Neurosurgery 17: 424–432PubMed Siegal T (1985) Surgical decompression of anterior and posterior malignant epidural tumors compressing the spinal cord: a prospective study. Neurosurgery 17: 424–432PubMed
96.
Zurück zum Zitat Simmons ED (2006) Vertebral Tumors. Surgical versus nonsurgical treatment. Clin Orthop 443: 233–247CrossRefPubMed Simmons ED (2006) Vertebral Tumors. Surgical versus nonsurgical treatment. Clin Orthop 443: 233–247CrossRefPubMed
97.
Zurück zum Zitat Sioutus PJ, Mshulam CF, Galicich JH (1995) Spinal metastases from solid tumors: analysis of factors affecting survival. Cancer 76: 1453–1459CrossRefPubMed Sioutus PJ, Mshulam CF, Galicich JH (1995) Spinal metastases from solid tumors: analysis of factors affecting survival. Cancer 76: 1453–1459CrossRefPubMed
98.
Zurück zum Zitat Smit JW, Goslings et al. (2000) Embolization for vertebral metastases of follicular thyreoid carcinoma. J Clin Endocrinol Metab 85: 989–994CrossRefPubMed Smit JW, Goslings et al. (2000) Embolization for vertebral metastases of follicular thyreoid carcinoma. J Clin Endocrinol Metab 85: 989–994CrossRefPubMed
99.
Zurück zum Zitat Sorensen S, Mouridsen H et al. (1994) Effect of high-dose dexamethasone in carcinomatous metastatic spinal cord compression treated with radiotherapy: a randomized trial. Eur J Cancer 30A: 22–27CrossRefPubMed Sorensen S, Mouridsen H et al. (1994) Effect of high-dose dexamethasone in carcinomatous metastatic spinal cord compression treated with radiotherapy: a randomized trial. Eur J Cancer 30A: 22–27CrossRefPubMed
100.
Zurück zum Zitat Steinmetz MP, Benzel E (2001) Management of metastatic tumors of the spine: strategies and operative indications. Neurosurg Focus 11: 1–6 Steinmetz MP, Benzel E (2001) Management of metastatic tumors of the spine: strategies and operative indications. Neurosurg Focus 11: 1–6
101.
Zurück zum Zitat Stener B (1971) Total en bloc spondylectomy in chondrosarcoma arising from the seventh thoracic vertebra. J Bone Joint Surg [Br] 53-B: 288–295 Stener B (1971) Total en bloc spondylectomy in chondrosarcoma arising from the seventh thoracic vertebra. J Bone Joint Surg [Br] 53-B: 288–295
102.
Zurück zum Zitat Sundaresan N, Boriani S, Rothman A, Holtzman R (2004) Tumors of the osseous spine. J Neurooncol 69: 273–290CrossRefPubMed Sundaresan N, Boriani S, Rothman A, Holtzman R (2004) Tumors of the osseous spine. J Neurooncol 69: 273–290CrossRefPubMed
103.
Zurück zum Zitat Sundaresan N, Hughes JEO, Sachdev VP, Berenstein A (1990) Treatment of spinal metastases from kidney cancer by presurgical embolization and resection. J Neurosurgery 73: 548–554 Sundaresan N, Hughes JEO, Sachdev VP, Berenstein A (1990) Treatment of spinal metastases from kidney cancer by presurgical embolization and resection. J Neurosurgery 73: 548–554
104.
Zurück zum Zitat Sundaresan N, Digiacinto GV, Hughes JE et al. (1991) Treatment of neoplastic spinal cord compression: results of a prospective study. Neurosurgery 29: 645–650CrossRefPubMed Sundaresan N, Digiacinto GV, Hughes JE et al. (1991) Treatment of neoplastic spinal cord compression: results of a prospective study. Neurosurgery 29: 645–650CrossRefPubMed
105.
Zurück zum Zitat Sundaresan N, Galicich JH, Lane JM et al. (1985) Treatment of neoplastic epidural cord compression by vertebral body resection and stabilization. J Neurosurg 63: 676–684PubMed Sundaresan N, Galicich JH, Lane JM et al. (1985) Treatment of neoplastic epidural cord compression by vertebral body resection and stabilization. J Neurosurg 63: 676–684PubMed
106.
Zurück zum Zitat Sundaresan N, Manhart K et al. (2002) Surgery for solitary metastases to the spine: rationale and results of treatment. Spine 27: 1802–1806CrossRefPubMed Sundaresan N, Manhart K et al. (2002) Surgery for solitary metastases to the spine: rationale and results of treatment. Spine 27: 1802–1806CrossRefPubMed
107.
Zurück zum Zitat Sundaresan N, Foley KM et al (1986) An anterior surgical approach to the upper thoracic vertebrae. J Neurosurgery 61: 686–690 Sundaresan N, Foley KM et al (1986) An anterior surgical approach to the upper thoracic vertebrae. J Neurosurgery 61: 686–690
108.
Zurück zum Zitat Tatsui H, Onomura T, Morishita S et al. (1996) Survival rates of patients with metastatic spinal cancer after scintigraphic detection of abnormal radioactive accumulation. Spine 21: 2143–2148CrossRefPubMed Tatsui H, Onomura T, Morishita S et al. (1996) Survival rates of patients with metastatic spinal cancer after scintigraphic detection of abnormal radioactive accumulation. Spine 21: 2143–2148CrossRefPubMed
109.
Zurück zum Zitat Tindal S (1991) Anesthesia for surgical management of spinal metastases. Probl Anesth 5: 80–90 Tindal S (1991) Anesthesia for surgical management of spinal metastases. Probl Anesth 5: 80–90
110.
Zurück zum Zitat Tokuhashi Y, Oda H, Oshima M, Ryu J (2005) A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine 30: 2186–2191CrossRefPubMed Tokuhashi Y, Oda H, Oshima M, Ryu J (2005) A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine 30: 2186–2191CrossRefPubMed
111.
Zurück zum Zitat Tokuhashi Y, Toriyama S et al. (1990) Scoring system for the preoperative evaluation of metastatic spine tumor prognosis. Spine 15: 1110–1113CrossRefPubMed Tokuhashi Y, Toriyama S et al. (1990) Scoring system for the preoperative evaluation of metastatic spine tumor prognosis. Spine 15: 1110–1113CrossRefPubMed
112.
Zurück zum Zitat Tomita K, Baba H, Tsuchiya H et al. (1997) Total en bloc spondylectomy: a new surgical technique for primary malignant vertebral tumors. Spine 22: 324–333CrossRefPubMed Tomita K, Baba H, Tsuchiya H et al. (1997) Total en bloc spondylectomy: a new surgical technique for primary malignant vertebral tumors. Spine 22: 324–333CrossRefPubMed
113.
Zurück zum Zitat Tomita K, Kobayashi T, Yoshida A et al. (2001) Surgical strategy for spinal metastases. Spine 26: 298–306CrossRefPubMed Tomita K, Kobayashi T, Yoshida A et al. (2001) Surgical strategy for spinal metastases. Spine 26: 298–306CrossRefPubMed
114.
Zurück zum Zitat Tomita K, Kawahara N, Ohnari H, Kose H (1994) Total en bloc spondylectomy and surgical circumspinal decompression for solitary metastases. Paraplegia 32: 36–46PubMed Tomita K, Kawahara N, Ohnari H, Kose H (1994) Total en bloc spondylectomy and surgical circumspinal decompression for solitary metastases. Paraplegia 32: 36–46PubMed
115.
Zurück zum Zitat Tomita T, Galicich JH, Sundaresan N (1983) Radiation therapy for spinal epidural metastases with complete block. Acta Radiol Oncol 22: 135–143PubMed Tomita T, Galicich JH, Sundaresan N (1983) Radiation therapy for spinal epidural metastases with complete block. Acta Radiol Oncol 22: 135–143PubMed
116.
Zurück zum Zitat Ushihio Y, Kim JH, Shapiro WR, Posner JB (1977) Treatment of experimental spinal cord compression by epidural neoplasm. J Neurosurgery 47: 422–429 Ushihio Y, Kim JH, Shapiro WR, Posner JB (1977) Treatment of experimental spinal cord compression by epidural neoplasm. J Neurosurgery 47: 422–429
117.
Zurück zum Zitat Vitaz T (2006) Staging, Classification, and oncological approaches for metastatic tumors involving the spine. In: Dickman C, Fehlings MG, Gokoslan ZL (eds) Spinal Cord and Spinal Column Tumors. Principles and Practice. Thieme Medical Publishers, New York Stuttgart, pp 387–403 Vitaz T (2006) Staging, Classification, and oncological approaches for metastatic tumors involving the spine. In: Dickman C, Fehlings MG, Gokoslan ZL (eds) Spinal Cord and Spinal Column Tumors. Principles and Practice. Thieme Medical Publishers, New York Stuttgart, pp 387–403
118.
Zurück zum Zitat Vrionis FD (2003) Surgical management of metastatic spinal neoplasms. Neurosurg Focus 15: 1–8PubMed Vrionis FD (2003) Surgical management of metastatic spinal neoplasms. Neurosurg Focus 15: 1–8PubMed
119.
Zurück zum Zitat Wai EK, Finkelstein JA, Tangente RP et al. (2003) Quality of life in surgical treatment of metastatic spine disease. Spine 28: 508–512CrossRefPubMed Wai EK, Finkelstein JA, Tangente RP et al. (2003) Quality of life in surgical treatment of metastatic spine disease. Spine 28: 508–512CrossRefPubMed
121.
Zurück zum Zitat Weigel B, Maghsudi M, Neumann C et al. (1999) Surgical management of symptomatic spinal metastases. Postoperative outcome and quality of life. Spine 24: 2240–2246CrossRefPubMed Weigel B, Maghsudi M, Neumann C et al. (1999) Surgical management of symptomatic spinal metastases. Postoperative outcome and quality of life. Spine 24: 2240–2246CrossRefPubMed
122.
Zurück zum Zitat Weill A, Simon JM et al. (1996) Spinal metastases: indication for and results of percutaneous injection of acrylic surgical cement. Radiology 199: 241–247PubMed Weill A, Simon JM et al. (1996) Spinal metastases: indication for and results of percutaneous injection of acrylic surgical cement. Radiology 199: 241–247PubMed
125.
Zurück zum Zitat Wetzel FT, Phillips FM (2000) Management of metastatic disease of the spine. Orthop Clin North Am 31: 611–621CrossRefPubMed Wetzel FT, Phillips FM (2000) Management of metastatic disease of the spine. Orthop Clin North Am 31: 611–621CrossRefPubMed
126.
Zurück zum Zitat Wilson DR, Mathis JM et al. (2000) Effects of augmentation on the mechanics of vertebral wedge fractures. Spine 25: 158–165CrossRefPubMed Wilson DR, Mathis JM et al. (2000) Effects of augmentation on the mechanics of vertebral wedge fractures. Spine 25: 158–165CrossRefPubMed
127.
Zurück zum Zitat Wise JJ, Fischgrund JS, Herkowitz HN et al. (1999) Complication, survival rates, and risk factors of surgery for metastatic disease of the spine. Spine 24: 1943–1951CrossRefPubMed Wise JJ, Fischgrund JS, Herkowitz HN et al. (1999) Complication, survival rates, and risk factors of surgery for metastatic disease of the spine. Spine 24: 1943–1951CrossRefPubMed
128.
Zurück zum Zitat Wong DA, Fornasier VL, MacNab I (1990) Spinal metastases: the obvious, the occult, and the impostors. Spine 15: 1–4CrossRefPubMed Wong DA, Fornasier VL, MacNab I (1990) Spinal metastases: the obvious, the occult, and the impostors. Spine 15: 1–4CrossRefPubMed
129.
Zurück zum Zitat Yao KC, Gokoslan ZL, Sundaresan N (2003) En bloc spondylectomy for spinal metastases: a review of techniques. Neurosurg Focus 15: 1–5PubMed Yao KC, Gokoslan ZL, Sundaresan N (2003) En bloc spondylectomy for spinal metastases: a review of techniques. Neurosurg Focus 15: 1–5PubMed
130.
Zurück zum Zitat Young RF, King GA (1980) Treatment of spinal epidural metastases: randomized prospective comparison of laminectomy and radiotherapy. J Neurosurgery 53: 741–748 Young RF, King GA (1980) Treatment of spinal epidural metastases: randomized prospective comparison of laminectomy and radiotherapy. J Neurosurgery 53: 741–748
Metadaten
Titel
Chirurgisches Management von Wirbelsäulenmetastasen
verfasst von
PD Dr. K.-D. Schaser
I. Melcher
T. Mittlmeier
A. Schulz
J.H. Seemann
N.P. Haas
A.C. Disch
Publikationsdatum
01.02.2007
Verlag
Springer-Verlag
Erschienen in
Die Unfallchirurgie / Ausgabe 2/2007
Print ISSN: 2731-7021
Elektronische ISSN: 2731-703X
DOI
https://doi.org/10.1007/s00113-007-1232-8

Weitere Artikel der Ausgabe 2/2007

Der Unfallchirurg 2/2007 Zur Ausgabe

Abstracts JOT

Abstracts

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Arthroskopie kann Knieprothese nicht hinauszögern

25.04.2024 Gonarthrose Nachrichten

Ein arthroskopischer Eingriff bei Kniearthrose macht im Hinblick darauf, ob und wann ein Gelenkersatz fällig wird, offenbar keinen Unterschied.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Ärztliche Empathie hilft gegen Rückenschmerzen

23.04.2024 Leitsymptom Rückenschmerzen Nachrichten

Personen mit chronischen Rückenschmerzen, die von einfühlsamen Ärzten und Ärztinnen betreut werden, berichten über weniger Beschwerden und eine bessere Lebensqualität.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.