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Experimental Brain Research

Erschienen in:

01.07.2016 | Research Article

Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex enhances working memory

verfasst von: Yasaman Bagherzadeh, Anahita Khorrami, Mohammad Reza Zarrindast, Seyed Vahid Shariat, Dimitrios Pantazis

Erschienen in: Experimental Brain Research | Ausgabe 7/2016

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Abstract

Neuroimaging and electrophysiological studies have unequivocally identified the dorsolateral prefrontal cortex (DLPFC) as a crucial structure for top-down control of working memory (WM) processes. By modulating the excitability of neurons in a targeted cortical area, transcranial magnetic stimulation (TMS) offers a unique way to modulate DLPFC function, opening the possibility of WM facilitation. Even though TMS neuromodulation effects over the left DLPFC have successfully improved WM performance in patients with depression and schizophrenia in a multitude of studies, raising the potential of TMS as a safe efficacious treatment for WM deficits, TMS interventions in healthy individuals have produced mixed and inconclusive results. Here, we stimulated the left DLPFC of healthy individuals using a high-frequency repetitive TMS protocol and evaluated behavioral performance in a battery of cognitive tasks. We found that TMS treatment enhanced WM performance in a verbal digit span and a visuospatial 2-back task.

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Titel: Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex enhances working memory
verfasst von: Yasaman Bagherzadeh
Anahita Khorrami
Mohammad Reza Zarrindast
Seyed Vahid Shariat
Dimitrios Pantazis
Publikationsdatum: 01.07.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Experimental Brain Research / Ausgabe 7/2016
Print ISSN: 0014-4819
Elektronische ISSN: 1432-1106
DOI: https://doi.org/10.1007/s00221-016-4580-1

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