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01.10.2014 | Review

Renal denervation: effects on atrial electrophysiology and arrhythmias

verfasst von: Dominik Linz, Arne van Hunnik, Christian Ukena, Sebastian Ewen, Felix Mahfoud, Stephan H. Schirmer, Matthias Lenski, Hans-Ruprecht Neuberger, Ulrich Schotten, Michael Böhm

Erschienen in: Clinical Research in Cardiology | Ausgabe 10/2014

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Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with significant morbidity and mortality. Currently, atrial endocardial catheter ablation, mainly targeting focal discharges in the pulmonary veins, is the most widely used interventional treatment of drug-refractory AF. Despite technical improvements, results are not yet optimal. There is ongoing search for alternative and/or complementary interventional targets. Conditions associated with increased sympathetic activation such as hypertension, heart failure and sleep apnea lead to structural, neural and electrophysiological changes in the atrium thereby contributing to the progression from paroxysmal to persistent AF and increasing recurrence rate of AF after PVI. Until now, interventional modulation of autonomic nervous system was limited by highly invasive techniques. Catheter-based renal denervation (RDN) was introduced as a minimally invasive approach to reduce renal and whole body sympathetic activation with accompanying blood pressure control and left-ventricular morphological and functional changes in resistant hypertension. This review focuses on the potential atrial antiarrhythmic and antiremodeling effects of RDN in AF patients with hypertension, heart failure, and sleep apnea and discusses the possible role of RDN in the treatment of AF.

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Titel: Renal denervation: effects on atrial electrophysiology and arrhythmias
verfasst von: Dominik Linz
Arne van Hunnik
Christian Ukena
Sebastian Ewen
Felix Mahfoud
Stephan H. Schirmer
Matthias Lenski
Hans-Ruprecht Neuberger
Ulrich Schotten
Michael Böhm
Publikationsdatum: 01.10.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Research in Cardiology / Ausgabe 10/2014
Print ISSN: 1861-0684
Elektronische ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-014-0695-1

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