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European Journal of Nutrition

Erschienen in:

01.08.2007 | ORIGINAL CONTRIBUTION

Effects of pre- and postnatal protein deprivation on atrial natriuretic peptide- (ANP-) granules of the right auricular cardiocytes

An ultrastructural morphometric study

verfasst von: Eliane Florencio Gama, Edson Aparecido Liberti, Romeu Rodrigues de Souza

Erschienen in: European Journal of Nutrition | Ausgabe 5/2007

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Abstract

Background

The atrial natriuretic peptide (ANP) is a peptide hormone that is mainly produced in the cardiocytes of the atria and auricles, where it is stored within secretory granules.

Aim of the study

The aim of the present work was to analyze the effects of pre- and postnatal protein malnutrition on weight gain, the size of the heart and the number and sizes of the ANP-granules in the cardiocytes of the rat’s right auricle. This study was conducted on 21-day-old rats from mothers exposed to 73% protein restriction during the gestation and lactation and on age-matched control animals. At this stage, both control and protein-deprived animals were killed by a lethal intraperitonial injection of sodic pentobarbital. The weight and the size of the heart were determined and ANP-granules of auricular cardiocytes were examined by transmission electron microscopy and ultrastructural morphometry.

Results

Protein deprivation of the mother throughout pregnancy, and the mother and unweaned rat pups in the first 21 postnatal days reduced the weights of pups to about 60% of the normally fed group. The weight and size of the heart were also reduced, by about 50%. Despite this, perinatal malnutrition did not significantly affect the numbers of ANP-granules/field in the cardiocytes. However, there was a small but significant reduction in the sizes of granules.

Conclusion

It is concluded that ANP-granules are protected from loss even when there is a substantial reduction in body weight and organ size caused by protein deprivation.

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Titel: Effects of pre- and postnatal protein deprivation on atrial natriuretic peptide- (ANP-) granules of the right auricular cardiocytes
An ultrastructural morphometric study
verfasst von: Eliane Florencio Gama
Edson Aparecido Liberti
Romeu Rodrigues de Souza
Publikationsdatum: 01.08.2007
Verlag: D. Steinkopff-Verlag
Erschienen in: European Journal of Nutrition / Ausgabe 5/2007
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-007-0652-0

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Abstract

Background

Aim of the study

Results

Conclusion

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