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Basic Research in Cardiology

Erschienen in:

01.11.2013 | Editorial

Myocardial infarction and coronary microvascular obstruction: an intimate, but complicated relationship

verfasst von: Gerd Heusch, Petra Kleinbongard, Andreas Skyschally

Erschienen in: Basic Research in Cardiology | Ausgabe 6/2013

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Excerpt

Timely reperfusion is the only way to rescue ischemic myocardium from impending infarction. However, reperfusion also adds a component of injury to that incurred during ischemia and thus contributes to final infarct size [6, 20, 28]. It appears that all conditioning strategies which delay infarct size development and/or reduce infarct size act through attenuation of such reperfusion injury [7]. Apart from its contribution to cardiomyocyte necrosis, reperfusion is frequently also characterized by the development of areas of no-reflow within the previously ischemic myocardium [10]. Evidence for microvascular no-reflow by angiography or MRI despite successfully reopened epicardial coronary arteries in patients with myocardial infarction is associated with impaired recovery of ventricular function and worse survival [19]. …

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Titel: Myocardial infarction and coronary microvascular obstruction: an intimate, but complicated relationship
verfasst von: Gerd Heusch
Petra Kleinbongard
Andreas Skyschally
Publikationsdatum: 01.11.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Basic Research in Cardiology / Ausgabe 6/2013
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-013-0380-y

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