Erschienen in:
01.08.2006 | Correspondence
Dopamine β-hydroxylase deficiency involves the central autonomic network
verfasst von:
William P. Cheshire Jr, Dennis W. Dickson, Kirsty F. Nahm, Horacio C. Kaufmann, Eduardo E. Benarroch
Erschienen in:
Acta Neuropathologica
|
Ausgabe 2/2006
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Excerpt
The sympathetic nervous system is essential to maintaining blood pressure homeostasis. Of critical importance are peripheral and central catecholaminergic neurons. During orthostatic stress, chromaffin granules of the adrenal medulla and synaptic vesicles of peripheral sympathetic neurons supply catecholamines which sustain arterial pressure. In the brainstem, catecholaminergic neurons in the rostral ventrolateral medulla (VLM) project to and tonically activate sympathetic preganglionic vasomotor neurons in the intermediolateral cell column of the spinal cord. Throughout, tyrosine hydroxylase (TH) is the rate-limiting enzyme, and dopamine β-hydroxylase (DBH) the final enzyme, in the catalytic synthesis of norepinephrine [
1]. …