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01.07.2008 | Review and Perspective

Pathogenesis of lymphangiomas

verfasst von: Susanne Wiegand, Behfar Eivazi, Peter J. Barth, Dirk Berens von Rautenfeld, Benedikt J. Folz, Robert Mandic, Jochen A. Werner

Erschienen in: Virchows Archiv | Ausgabe 1/2008

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Abstract

Based on various hypotheses concerning lymphangiogenesis published in the literature, different putative mechanisms of lymphangioma development are discussed including failure of the lymphatic system to connect with or separate from the venous system, abnormal budding of the lymphatic system from the cardinal vein, or acquired processes such as traumata, infections, chronic inflammations, and obstructions. Increasingly, the possible influence of lymphangiogenic growth factors on the development of lymphangiomas is discussed. The proved expression of different growth factors in the endothelium of lymphangiomas leads to new hypotheses regarding the pathogenesis of lymphangiomas. Thus, further studies on the lymphangiogenesis and the development of lymphangiomas will have to clarify as to whether lymphangiomas are true malformations or neoplastic in nature.

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Titel: Pathogenesis of lymphangiomas
verfasst von: Susanne Wiegand
Behfar Eivazi
Peter J. Barth
Dirk Berens von Rautenfeld
Benedikt J. Folz
Robert Mandic
Jochen A. Werner
Publikationsdatum: 01.07.2008
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 1/2008
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-008-0611-z

Springer Medizin

Pathogenesis of lymphangiomas

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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