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Pediatric Nephrology

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01.03.2013 | Educational Review

Treatment of steroid-sensitive nephrotic syndrome: new guidelines from KDIGO

verfasst von: Rebecca M. Lombel, Debbie S. Gipson, Elisabeth M. Hodson

Erschienen in: Pediatric Nephrology | Ausgabe 3/2013

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Abstract

The 2012 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline on glomerulonephritis (GN) is intended to assist the practitioner caring for patients with GN. Two chapters of this guideline focus specifically on nephrotic syndrome in children. Guideline development followed a thorough evidence review, and management recommendations and suggestions were based on the best available evidence. Critical appraisal of the quality of evidence and strength of recommendations followed the Grades of Recommendation Assessment, Development and Evaluation (GRADE) approach. Chapters 3 and 4 of the guideline focus on the management of nephrotic syndrome in children aged 1–18 years. Guideline recommendations for children who have steroid-sensitive nephrotic syndrome (SNSS), defined by their response to corticosteroid therapy with complete remission, are addressed here. Recommendations for those with steroid-resistant nephrotic syndrome (SRNS) (i.e., do not achieve complete remission) are discussed in the companion article. Limitations of the evidence, including the paucity of large-scale randomized controlled trials, are discussed. This article provides a short description of the KDIGO process, the guideline recommendations for treatment of SSNS in children and a brief review of relevant treatment trials related to each recommendation.

Prednisone and prednisolone are equivalent, used in the same dosage, and have both been used in RCTs. All later references to prednisone or oral corticosteroids refer to prednisone or prednisolone.

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Titel: Treatment of steroid-sensitive nephrotic syndrome: new guidelines from KDIGO
verfasst von: Rebecca M. Lombel
Debbie S. Gipson
Elisabeth M. Hodson
Publikationsdatum: 01.03.2013
Verlag: Springer-Verlag
Erschienen in: Pediatric Nephrology / Ausgabe 3/2013
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-012-2310-x

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