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Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: long-term follow-up

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Abstract.

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been shown to be an effective therapy for the treatment of advanced Parkinson's disease (PD). Fortyseven patients were bilaterally implanted for STN DBS and clinically evaluated according to the Core Assessment Program for Intracerebral Transplantations before surgery and 3, 12 and 24 months after surgery. Electrical stimulation led to a significant improvement in motor symptoms and in the quality of life, allowing a significant reduction of dopaminergic drugs with a consequent improvement of drug-induced dyskinesias. Statistical differences were observed between UPDRS parts II, III and IV values and daily levodopa dosage in the pre- and postoperative periods, while no differences were evident between the 3 postoperative conditions.

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Authors and Affiliations

  1. Department of Neuroscience, University of Turin, Via Cherasco 15, I-10126 Turin, Italy, , , , , , IT

    A. Tavella, B. Bergamasco, E. Bosticco, P. Perozzo, M. Rizzone, E. Torre & L. Lopiano

  2. Department of Neurosurgery, CTO Hospital, Turin, Italy, , , , , , IT

    M. Lanotte

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  1. A. Tavella
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  2. B. Bergamasco
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  3. E. Bosticco
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  4. M. Lanotte
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  5. P. Perozzo
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  6. M. Rizzone
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  7. E. Torre
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  8. L. Lopiano
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Correspondence to A. Tavella

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Tavella, A., Bergamasco, B., Bosticco, E. et al. Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: long-term follow-up. Neurol Sci 23 (Suppl 2), s111–s112 (2002). https://doi.org/10.1007/s100720200094

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  • DOI: https://doi.org/10.1007/s100720200094

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