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Novel Biodegradable Polycaprolactone Occlusion Device Combining Nanofibrous PLGA/Collagen Membrane for Closure of Atrial Septal Defect (ASD)

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Abstract

The purpose of this report was to develop novel biodegradable occlusion devices for closure of atrial septal defects (ASD). To manufacture the biodegradable occluders, polycaprolactone (PCL) components were first fabricated by a lab-scale micro-injection molding machine. They were then assembled and hot-spot welded into double umbrella-like devices of 50 mm in diameter. A special mechanism at the axis of the occluder was designed to self-lock the occluder after the two umbrellas were expanded. Furthermore, a nanofibrous matrix of poly-d-l-lactide-glycolide (PLGA)/type I collagen blend was produced via electrospinning to develop biodegradable and biomimetic anti-shunt membranes for the occluders. Characterization of the biodegradable PCL occluders was carried out. PCL occluders exhibited mechanical properties comparable to that of commercially available Amplatzer occluders. The sealing capability of biodegradable occluders was found superior to that of Amplatzer occluders. In addition, the cell attachment and spreading of endothelial cells seeded on the PLGA/collagen nanofibrous matrix and the interaction between cells and PLGA/collagen nanofibers were studied. The nanofibrous membranes made of PLGA/collagen were very effective in promoting cell proliferation during culture.

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Authors and Affiliations

  1. Biomaterials Lab, Mechanical Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 333, Taiwan

    Shih-Jung Liu, Kang-Ming Peng, Chao-Ying Hsiao & Kuo-Sheng Liu

  2. Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan

    Kuo-Sheng Liu

  3. Division of Pediatric Cardiology, Department of Pediatrics, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan

    Hung-Tao Chung

  4. Department of Physiology and Pharmacology, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan

    Jan-Kan Chen

Authors
  1. Shih-Jung Liu
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  2. Kang-Ming Peng
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  3. Chao-Ying Hsiao
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  4. Kuo-Sheng Liu
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  5. Hung-Tao Chung
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  6. Jan-Kan Chen
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Correspondence to Shih-Jung Liu.

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Associate Editor Jennifer West oversaw the review of this article.

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Liu, SJ., Peng, KM., Hsiao, CY. et al. Novel Biodegradable Polycaprolactone Occlusion Device Combining Nanofibrous PLGA/Collagen Membrane for Closure of Atrial Septal Defect (ASD). Ann Biomed Eng 39, 2759–2766 (2011). https://doi.org/10.1007/s10439-011-0368-4

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  • DOI: https://doi.org/10.1007/s10439-011-0368-4

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