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European Journal of Epidemiology
Erschienen in: European Journal of Epidemiology 12/2014

01.12.2014 | STUDY UPDATE

The Generation R Study: Biobank update 2015

verfasst von: Claudia J. Kruithof, Marjolein N. Kooijman, Cornelia M. van Duijn, Oscar H. Franco, Johan C. de Jongste, Caroline C. W. Klaver, Johan P. Mackenbach, Henriëtte A. Moll, Hein Raat, Edmond H. H. M. Rings, Fernando Rivadeneira, Eric A. P. Steegers, Henning Tiemeier, Andre G. Uitterlinden, Frank C. Verhulst, Eppo B. Wolvius, Albert Hofman, Vincent W. V. Jaddoe

Erschienen in: European Journal of Epidemiology | Ausgabe 12/2014

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Abstract

The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. In total, 9,778 mothers were enrolled in the study. Data collection in children and their parents include questionnaires, interviews, detailed physical and ultrasound examinations, behavioural observations, Magnetic Resonance Imaging and biological samples. Efforts have been conducted for collecting biological samples including blood, hair, faeces, nasal swabs, saliva and urine samples and generating genomics data on DNA, RNA and microbiome. In this paper, we give an update of the collection, processing and storage of these biological samples and available measures. Together with detailed phenotype measurements, these biological samples provide a unique resource for epidemiological studies focused on environmental exposures, genetic and genomic determinants and their interactions in relation to growth, health and development from fetal life onwards.
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207.
Saridjan NS, Henrichs J, Schenk JJ, Jaddoe VW, Hofman A, Kirschbaum C, et al. Diurnal cortisol rhythm and cognitive functioning in toddlers: the Generation R Study. Child Neuropsychol. 2014;20(2):210–29.PubMed
208.
Saridjan NS, Velders FP, Jaddoe VW, Hofman A, Verhulst FC, Tiemeier H. The longitudinal association of the diurnal cortisol rhythm with internalizing and externalizing problems in pre-schoolers. The Generation R Study. Psychoneuroendocrinology. 2014;50C:118–29.
209.
Labout JA, Duijts L, Arends LR, Jaddoe VW, Hofman A, de Groot R, et al. Factors associated with pneumococcal carriage in healthy Dutch infants: the generation R study. J Pediatr. 2008;153(6):771–6.PubMed
210.
Lebon A, Labout JA, Verbrugh HA, Jaddoe VW, Hofman A, van Wamel W, et al. Dynamics and determinants of Staphylococcus aureus carriage in infancy: the Generation R Study. J Clin Microbiol. 2008;46(10):3517–21.PubMedCentralPubMed
211.
Lebon A, Labout JA, Verbrugh HA, Jaddoe VW, Hofman A, van Wamel WJ, et al. Role of Staphylococcus aureus nasal colonization in atopic dermatitis in infants: the Generation R Study. Arch Pediatr Adolesc Med. 2009;163(8):745–9.PubMed
212.
Verhaegh SJ, Lebon A, Saarloos JA, Verbrugh HA, Jaddoe VW, Hofman A, et al. Determinants of Moraxella catarrhalis colonization in healthy Dutch children during the first 14 months of life. Clin Microbiol Infect. 2010;16(7):992–7.PubMed
213.
Verkaik NJ, Lebon A, de Vogel CP, Hooijkaas H, Verbrugh HA, Jaddoe VW, et al. Induction of antibodies by Staphylococcus aureus nasal colonization in young children. Clin Microbiol Infect. 2010;16(8):1312–7.PubMed
214.
Lebon A, Moll HA, Tavakol M, van Wamel WJ, Jaddoe VW, Hofman A, et al. Correlation of bacterial colonization status between mother and child: the Generation R Study. J Clin Microbiol. 2010;48(3):960–2.PubMedCentralPubMed
215.
Labout JA, Duijts L, Lebon A, de Groot R, Hofman A, Jaddoe VV, et al. Risk factors for otitis media in children with special emphasis on the role of colonization with bacterial airway pathogens: the Generation R study. Eur J Epidemiol. 2011;26(1):61–6.PubMedCentralPubMed
216.
Verhaegh SJ, Snippe ML, Levy F, Verbrugh HA, Jaddoe VW, Hofman A, et al. Colonization of healthy children by Moraxella catarrhalis is characterized by genotype heterogeneity, virulence gene diversity and co-colonization with Haemophilus influenzae. Microbiology. 2011;157(1):169–78.
217.
Ye X, Pierik FH, Hauser R, Duty S, Angerer J, Park MM, et al. Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study. Environ Res. 2008;108(2):260–7.PubMedCentralPubMed
218.
Ye X, Pierik FH, Angerer J, Meltzer HM, Jaddoe VW, Tiemeier H, et al. Levels of metabolites of organophosphate pesticides, phthalates, and bisphenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa). Int J Hyg Environ Health. 2009;212(5):481–91.PubMedCentralPubMed
219.
Snijder CA, Heederik D, Pierik FH, Hofman A, Jaddoe VW, Koch HM, et al. Fetal growth and prenatal exposure to bisphenol A: the generation R study. Environ Health Perspect. 2013;121(3):393–8.PubMedCentralPubMed
220.
Jusko TA, Shaw PA, Snijder CA, Pierik FH, Koch HM, Hauser R, et al. Reproducibility of urinary bisphenol A concentrations measured during pregnancy in the Generation R Study. J Expo Sci Environ Epidemiol. 2014;24(5):532–6.PubMed
221.
El Marroun H, Tiemeier H, Jaddoe VW, Hofman A, Verhulst FC, van den Brink W, et al. Agreement between maternal cannabis use during pregnancy according to self-report and urinalysis in a population-based cohort: the Generation R Study. Eur Addict Res. 2011;17(1):37–43.PubMed
222.
Rours GI, Duijts L, Moll HA, Arends LR, de Groot R, Jaddoe VW, et al. Chlamydia trachomatis infection during pregnancy associated with preterm delivery: a population-based prospective cohort study. Eur J Epidemiol. 2011;26(6):493–502.PubMedCentralPubMed
223.
van Mil NH, Tiemeier H, Bongers-Schokking JJ, Ghassabian A, Hofman A, Hooijkaas H, et al. Low urinary iodine excretion during early pregnancy is associated with alterations in executive functioning in children. J Nutr. 2012;142(12):2167–74.PubMed
224.
Ghassabian A, Steenweg-de Graaff J, Peeters RP, Ross HA, Jaddoe VW, Hofman A, et al. Maternal urinary iodine concentration in pregnancy and children’s cognition: results from a population-based birth cohort in an iodine-sufficient area. BMJ Open. 2014;4(6):e005520.PubMedCentralPubMed
225.
Metadaten
Titel
The Generation R Study: Biobank update 2015
verfasst von
Claudia J. Kruithof
Marjolein N. Kooijman
Cornelia M. van Duijn
Oscar H. Franco
Johan C. de Jongste
Caroline C. W. Klaver
Johan P. Mackenbach
Henriëtte A. Moll
Hein Raat
Edmond H. H. M. Rings
Fernando Rivadeneira
Eric A. P. Steegers
Henning Tiemeier
Andre G. Uitterlinden
Frank C. Verhulst
Eppo B. Wolvius
Albert Hofman
Vincent W. V. Jaddoe
Publikationsdatum
01.12.2014
Verlag
Springer Netherlands
Erschienen in
European Journal of Epidemiology / Ausgabe 12/2014
Print ISSN: 0393-2990
Elektronische ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-014-9980-6

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