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Journal of Assisted Reproduction and Genetics

Erschienen in:

01.08.2012 | REVIEW

Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advances

verfasst von: Gary Levy, Micah J. Hill, Stephanie Beall, Shvetha M. Zarek, James H. Segars, William H. Catherino

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 8/2012

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Abstract

Purpose

Uterine leiomyomas are common, benign, reproductive tract tumors affecting a majority of reproductive aged women. They are associated with gynecologic morbidity and detrimentally affect reproductive potential. The etiology of leiomyomas is poorly understood and their diagnosis prior to treatment with Assisted Reproductive Technologies (ART) represents a management dilemma. The purpose of this paper is to review known genetic and molecular contributions to the etiologies of leiomyomas, describe their impact on ART outcomes and reproductive potential, and review alternative therapies and future directions in management.

Methods

A critical review of the literature pertaining to genetic component of uterine leiomyomas, their impact on ART and pregnancy and leiomyoma therapeutics was performed.

Results

Uterine leiomyomas are characterized by complex molecular mechanisms. Their location and size determines their potential detriment to ART and reproductive function and novel therapeutic modalities are being developed.

Conclusion

The high prevalence of uterine leiomyomas and their potential detrimental influence on ART and reproductive function warrants continued well-designed studies to ascertain their etiology, optimal treatment and novel less morbid therapies.

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Titel: Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advances
verfasst von: Gary Levy
Micah J. Hill
Stephanie Beall
Shvetha M. Zarek
James H. Segars
William H. Catherino
Publikationsdatum: 01.08.2012
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 8/2012
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-012-9784-0

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Leiomyoma: genetics, assisted reproduction, pregnancy and therapeutic advances

Abstract

Purpose

Methods

Results

Conclusion

Neu im Fachgebiet Gynäkologie und Geburtshilfe

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Die Highlights vom Kongress des American College of Cardiology 2024

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Abstract

Purpose

Methods

Results

Conclusion

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