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Current Hypertension Reports

Erschienen in:

01.12.2013 | Prevention of Hypertension: Public Health Challenges (P Muntner, Section Editor)

Progress and Future Aspects in Genetics of Human Hypertension

verfasst von: Qi Zhao, Tanika N. Kelly, Changwei Li, Jiang He

Erschienen in: Current Hypertension Reports | Ausgabe 6/2013

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Abstract

Hypertension has become a major global health burden due to its high prevalence and associated increase in risk of cardiovascular disease and premature death. It is well established that hypertension is determined by both genetic and environmental factors and their complex interactions. Recent large-scale meta-analyses of genome-wide association studies (GWAS) have successfully identified a total of 38 loci which achieved genome-wide significance (P < 5 × 10^-8) for their association with blood pressure (BP). Although the heritability of BP explained by these loci is very limited, GWAS meta-analyses have elicited renewed optimism in hypertension genomics research, highlighting novel pathways influencing BP and elucidating genetic mechanisms underlying BP regulation. This review summarizes evolving progress in the rapidly moving field of hypertension genetics and highlights several promising approaches for dissecting the remaining heritability of BP. It also discusses the future translation of genetic findings to hypertension treatment and prevention.

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Titel: Progress and Future Aspects in Genetics of Human Hypertension
verfasst von: Qi Zhao
Tanika N. Kelly
Changwei Li
Jiang He
Publikationsdatum: 01.12.2013
Verlag: Springer US
Erschienen in: Current Hypertension Reports / Ausgabe 6/2013
Print ISSN: 1522-6417
Elektronische ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-013-0388-6

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