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Erschienen in: Current Neurology and Neuroscience Reports 5/2012

01.10.2012 | Neurotrauma (J Levine, Section Editor)

Sports-Related Concussion Testing

verfasst von: Mark S. Dziemianowicz, Matthew P. Kirschen, Bryan A. Pukenas, Eric Laudano, Laura J. Balcer, Steven L. Galetta

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 5/2012

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Abstract

Due to the recent focus on concussion in sports, a number of tests have been developed to diagnose and manage concussion. While each test measures different brain functions, no single test has been shown to quickly and reliably assess concussion in all cases. In addition, most of the current concussion tests have not been validated by scientific investigation. This review identifies the pros and cons of the most commonly used noninvasive tests for concussion in order to provide a more complete picture of the resources that are available for concussion testing. The potential utility of research tools such as the head impact telemetry system, advanced magnetic resonance imaging protocols, and biomarkers are discussed in the context of the currently employed tools.
Literatur
1.
Zurück zum Zitat Meehan WP, Micheli LJ. Concussion results in deficits in neurocognitive functioning. Clin Sports Med. 2011;30:28–8. Meehan WP, Micheli LJ. Concussion results in deficits in neurocognitive functioning. Clin Sports Med. 2011;30:28–8.
2.
Zurück zum Zitat Guskiewicz KM, McCrea M, Marshall SW, et al. Cumulative effects associated with recurrent concussion in collegiate football players: the NCAA Concussion Study. JAMA. 2003;290:2549–55.PubMedCrossRef Guskiewicz KM, McCrea M, Marshall SW, et al. Cumulative effects associated with recurrent concussion in collegiate football players: the NCAA Concussion Study. JAMA. 2003;290:2549–55.PubMedCrossRef
3.
Zurück zum Zitat Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006;21:375–8.PubMedCrossRef Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006;21:375–8.PubMedCrossRef
4.
Zurück zum Zitat Concussion (mild traumatic brain injury) and the team physician: a consensus statement. Med Sci Sports Exerc. 2006, 38:395–399. Concussion (mild traumatic brain injury) and the team physician: a consensus statement. Med Sci Sports Exerc. 2006, 38:395–399.
5.
Zurück zum Zitat McCrory P, Johnston K, Meeuwisse W, et al. Summary and agreement statement of the 2nd international conference on concussion in sport, Prague 2004. Br J Sports Med. 2005;39:196–204.PubMed McCrory P, Johnston K, Meeuwisse W, et al. Summary and agreement statement of the 2nd international conference on concussion in sport, Prague 2004. Br J Sports Med. 2005;39:196–204.PubMed
6.
Zurück zum Zitat Daneshvar DH, Nowinski CJ, McKee AC, Cantu RC. The epidemiology of sport-related concussion. Clin Sports Med. 2011;30:1–17.PubMedCrossRef Daneshvar DH, Nowinski CJ, McKee AC, Cantu RC. The epidemiology of sport-related concussion. Clin Sports Med. 2011;30:1–17.PubMedCrossRef
7.
Zurück zum Zitat • Galetta KM, Brandes LE, Maki K, et al. The King-Devick test and sports-related concussion: study of a rapid visual screening tool in a collegiate cohort. J Neurol Sci. 2011;309:34–9. This identifies the need for a rapid sideline screening tool and proposes one possible test, the King-Devick test. PubMedCrossRef • Galetta KM, Brandes LE, Maki K, et al. The King-Devick test and sports-related concussion: study of a rapid visual screening tool in a collegiate cohort. J Neurol Sci. 2011;309:34–9. This identifies the need for a rapid sideline screening tool and proposes one possible test, the King-Devick test. PubMedCrossRef
8.
Zurück zum Zitat Halstead ME, Walter KD. Sports-related concussion in children and adolescents. Pediatrics. 2010;126:597–615.PubMedCrossRef Halstead ME, Walter KD. Sports-related concussion in children and adolescents. Pediatrics. 2010;126:597–615.PubMedCrossRef
9.
Zurück zum Zitat Sim A, Terryberry-Spohr L, Wilson KR. Prolonged recovery of memory functioning after mild traumatic brain injury in adolescent athletes. J Neurosurg. 2008;108:511–6.PubMedCrossRef Sim A, Terryberry-Spohr L, Wilson KR. Prolonged recovery of memory functioning after mild traumatic brain injury in adolescent athletes. J Neurosurg. 2008;108:511–6.PubMedCrossRef
10.
Zurück zum Zitat Gavett BE, Stern RA, McKee AC. Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma. Clin Sports Med. 2011;30:179–88.PubMedCrossRef Gavett BE, Stern RA, McKee AC. Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma. Clin Sports Med. 2011;30:179–88.PubMedCrossRef
11.
Zurück zum Zitat Guskiewicz KM, Weaver NL, Padua DA, Garrett WE. Epidemiology of concussion in collegiate and high school football players. Am J Sports Med. 2000;28:643–50.PubMed Guskiewicz KM, Weaver NL, Padua DA, Garrett WE. Epidemiology of concussion in collegiate and high school football players. Am J Sports Med. 2000;28:643–50.PubMed
12.
13.
Zurück zum Zitat Boden BP, Tacchetti RL, Cantu RC, et al. Catestrophic head injuries in high school and college football players. Am J Sports. 2007;35:1075–81.CrossRef Boden BP, Tacchetti RL, Cantu RC, et al. Catestrophic head injuries in high school and college football players. Am J Sports. 2007;35:1075–81.CrossRef
14.
Zurück zum Zitat Notebaert AJ, Guskiewicz KM. Current trends in athletic training practice for concussion assessment and management. J Athl Train. 2005;40:320–5.PubMed Notebaert AJ, Guskiewicz KM. Current trends in athletic training practice for concussion assessment and management. J Athl Train. 2005;40:320–5.PubMed
15.
Zurück zum Zitat Covassin T, Elbin 3rd R, Stiller-Ostrowski J. Current sport-related concussion teaching and clinical practices of sports medicine professionals. J Athl Train. 2009;44:400–4.PubMedCrossRef Covassin T, Elbin 3rd R, Stiller-Ostrowski J. Current sport-related concussion teaching and clinical practices of sports medicine professionals. J Athl Train. 2009;44:400–4.PubMedCrossRef
16.
Zurück zum Zitat McCrory P, Meeuwisse W, Johnston K, et al. Consensus statement on Concussion in Sport 3rd International Conference on Concussion in Sport held in Zurich, November 2008. Clin J Sport Med. 2009;19:185–200.PubMedCrossRef McCrory P, Meeuwisse W, Johnston K, et al. Consensus statement on Concussion in Sport 3rd International Conference on Concussion in Sport held in Zurich, November 2008. Clin J Sport Med. 2009;19:185–200.PubMedCrossRef
17.
Zurück zum Zitat Halstead ME, Walter KD, and the Council on Sports Medicine and Fitness. Sport-related concussion in children and adolescents. Pediatrics. 2010;126:597.PubMedCrossRef Halstead ME, Walter KD, and the Council on Sports Medicine and Fitness. Sport-related concussion in children and adolescents. Pediatrics. 2010;126:597.PubMedCrossRef
18.
Zurück zum Zitat McCrory P, Meeuwisse W, Johnston K, et al. Consensus statement on Concussion in Sport 3rd International Conference on Concussion in Sport held in Zurich, November 2008. Clin J Sport Med. 2009;19:185–200.PubMedCrossRef McCrory P, Meeuwisse W, Johnston K, et al. Consensus statement on Concussion in Sport 3rd International Conference on Concussion in Sport held in Zurich, November 2008. Clin J Sport Med. 2009;19:185–200.PubMedCrossRef
19.
Zurück zum Zitat McCrea M. Standardized mental status testing of acute concussion. Clin J Sport Med. 2001;11:176–81.PubMedCrossRef McCrea M. Standardized mental status testing of acute concussion. Clin J Sport Med. 2001;11:176–81.PubMedCrossRef
20.
Zurück zum Zitat Coldren RL, Kelly MP, Parish RV, Dretsch M, Russell ML. Evaluation of the military acute concussion evaluation for use in combat operations more than 12 hours after injury. Mil Med. 2010;175:477–81.PubMed Coldren RL, Kelly MP, Parish RV, Dretsch M, Russell ML. Evaluation of the military acute concussion evaluation for use in combat operations more than 12 hours after injury. Mil Med. 2010;175:477–81.PubMed
21.
Zurück zum Zitat King NS, Crawford S, Wenden FJ, Moss NEG, Wade DT. The rivermead post concussion symptoms questionnaire: a measure of symptoms commonly experienced after head injury and its reliability. J Neurol. 1995;242:587–92.PubMedCrossRef King NS, Crawford S, Wenden FJ, Moss NEG, Wade DT. The rivermead post concussion symptoms questionnaire: a measure of symptoms commonly experienced after head injury and its reliability. J Neurol. 1995;242:587–92.PubMedCrossRef
22.
Zurück zum Zitat Potter S, Leigh E, Wade D, Fleminger S. The rivermead post concussion symptoms questionnaire. J Neurol. 2006;253:1603–14.PubMedCrossRef Potter S, Leigh E, Wade D, Fleminger S. The rivermead post concussion symptoms questionnaire. J Neurol. 2006;253:1603–14.PubMedCrossRef
23.
Zurück zum Zitat Lovell MR, Collins MW. Neuropsychological assessment of the college football player. J Head Trauma Rehabil. 1998;13:9–26.PubMedCrossRef Lovell MR, Collins MW. Neuropsychological assessment of the college football player. J Head Trauma Rehabil. 1998;13:9–26.PubMedCrossRef
24.
Zurück zum Zitat Lovell MR, Iverson GL, Collins MW, McKeag D, Maroon JC. Does loss of consciousness predict neuropsychological decrements after concussion? Clin J Sports Med. 1999;9:193–8.CrossRef Lovell MR, Iverson GL, Collins MW, McKeag D, Maroon JC. Does loss of consciousness predict neuropsychological decrements after concussion? Clin J Sports Med. 1999;9:193–8.CrossRef
25.
Zurück zum Zitat Putukian M. The acute symptoms of sport-related concussion: diagnosis and on-field management. Clin Sports Med. 2011;30:49–61.PubMedCrossRef Putukian M. The acute symptoms of sport-related concussion: diagnosis and on-field management. Clin Sports Med. 2011;30:49–61.PubMedCrossRef
26.
Zurück zum Zitat • Alla S, Sullivan SJ, Hale L, et al. Self-report scales/checklists for the measurement of concussion symptoms: a systematic review. Br J Sports Med. 2009;43 Suppl 1:i3–i12. This systematically analyzes the most commonly used symptom scales and checklists for diagnosing concussion. It also emphasizes the unmet need for scientific scrutiny to support these scales and checklists. PubMedCrossRef • Alla S, Sullivan SJ, Hale L, et al. Self-report scales/checklists for the measurement of concussion symptoms: a systematic review. Br J Sports Med. 2009;43 Suppl 1:i3–i12. This systematically analyzes the most commonly used symptom scales and checklists for diagnosing concussion. It also emphasizes the unmet need for scientific scrutiny to support these scales and checklists. PubMedCrossRef
28.
Zurück zum Zitat Piland SG, Motl RW, Ferrara MS, Peterson CL. Evidence for the factorial and construct validity of a self-report concussion symptoms scale. J Athl Train. 2003;38:104–12.PubMed Piland SG, Motl RW, Ferrara MS, Peterson CL. Evidence for the factorial and construct validity of a self-report concussion symptoms scale. J Athl Train. 2003;38:104–12.PubMed
29.
Zurück zum Zitat Piland SG, Motl RW, Guskiewicz KM, McCrea M, Ferrara MS. Structural validity of a self-report concussion-related symptom scale. Med Sci Sports Exerc. 2006;38:27–32.PubMedCrossRef Piland SG, Motl RW, Guskiewicz KM, McCrea M, Ferrara MS. Structural validity of a self-report concussion-related symptom scale. Med Sci Sports Exerc. 2006;38:27–32.PubMedCrossRef
30.
Zurück zum Zitat McCrea M, Barr WB, Guskiewicz K, et al. Standard regression-based methods for measuring recovery after sport-related concussion. J Int Neuropsychol Soc. 2005;11:58–69.PubMedCrossRef McCrea M, Barr WB, Guskiewicz K, et al. Standard regression-based methods for measuring recovery after sport-related concussion. J Int Neuropsychol Soc. 2005;11:58–69.PubMedCrossRef
31.
Zurück zum Zitat Maddocks Dl, Dicker GD, Saling MM. The assessment of orientation following concussion in athletes. Clin J Sport Med. 1995;5:32–3.PubMedCrossRef Maddocks Dl, Dicker GD, Saling MM. The assessment of orientation following concussion in athletes. Clin J Sport Med. 1995;5:32–3.PubMedCrossRef
32.
Zurück zum Zitat Schneiders AG, Sullivan SJ, Handcock P, et al.: Sports concussion assessment: the effect of exercise on dynamic and static balance. Scand J Med Sci Sports 2010, Epub ahead of print. Schneiders AG, Sullivan SJ, Handcock P, et al.: Sports concussion assessment: the effect of exercise on dynamic and static balance. Scand J Med Sci Sports 2010, Epub ahead of print.
33.
Zurück zum Zitat Hunt TN, Ferrara MS, Bornstein RA, et al. The reliability of the modified balance error scoring system. Clin J Sport Med. 2009;19:471–5.PubMedCrossRef Hunt TN, Ferrara MS, Bornstein RA, et al. The reliability of the modified balance error scoring system. Clin J Sport Med. 2009;19:471–5.PubMedCrossRef
34.
Zurück zum Zitat Broglio SP, Schnebel B, Sosnoff JJ, et al. Biomechanical properties of concussions in high school football. Med Sci Sports Exerc. 2010;42:2064–71.PubMedCrossRef Broglio SP, Schnebel B, Sosnoff JJ, et al. Biomechanical properties of concussions in high school football. Med Sci Sports Exerc. 2010;42:2064–71.PubMedCrossRef
35.
Zurück zum Zitat Broglio SP, Eckner JT, Surma T, Kutcher JS: Post-concussion cognitive declines and symptomatology are not related to concussion biomechanics in high school football players. J Neurotrauma 2011, Epub ahead of print. Broglio SP, Eckner JT, Surma T, Kutcher JS: Post-concussion cognitive declines and symptomatology are not related to concussion biomechanics in high school football players. J Neurotrauma 2011, Epub ahead of print.
36.
Zurück zum Zitat • Talavage TM, Nauman E, Breedlove EL, et al.: Functionally-detected cognitive impairment in high school football players without clinically-diagnosed concussion. J Neurotrauma 2010, Epub ahead of print. This shows that an accrual of sub-concussive impact can lead to brain injury and concussion-like symptoms. It also compares the results of the HITS, ImPACT, and fMRI. • Talavage TM, Nauman E, Breedlove EL, et al.: Functionally-detected cognitive impairment in high school football players without clinically-diagnosed concussion. J Neurotrauma 2010, Epub ahead of print. This shows that an accrual of sub-concussive impact can lead to brain injury and concussion-like symptoms. It also compares the results of the HITS, ImPACT, and fMRI.
37.
Zurück zum Zitat Guskiewicz KM, Mihalik JP, Shankar V, et al. Measurement of head impacts in collegiate football players: relationship between head impact biomechanics and acute clinical outcome after concussion. Neurosurgery. 2007;61:1244–52.PubMedCrossRef Guskiewicz KM, Mihalik JP, Shankar V, et al. Measurement of head impacts in collegiate football players: relationship between head impact biomechanics and acute clinical outcome after concussion. Neurosurgery. 2007;61:1244–52.PubMedCrossRef
38.
Zurück zum Zitat McAllister TW, Flashman LA, Maerlender A, et al. Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletes. Neurology. 2012;78:1777–84.PubMedCrossRef McAllister TW, Flashman LA, Maerlender A, et al. Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletes. Neurology. 2012;78:1777–84.PubMedCrossRef
39.
Zurück zum Zitat Deibert E, Kryscio R. How many HITS are too many? The use of accelerometers to study sports-related concussion. Neurology. 2012;78:1712–3.PubMedCrossRef Deibert E, Kryscio R. How many HITS are too many? The use of accelerometers to study sports-related concussion. Neurology. 2012;78:1712–3.PubMedCrossRef
40.
Zurück zum Zitat McCrea M, Kelly JP, Randolph C, et al. Standardized assessment of concussion (SAC): on-site mental status evaluation of the athlete. J Head Trauma Rehabil. 1998;13:27–35.PubMedCrossRef McCrea M, Kelly JP, Randolph C, et al. Standardized assessment of concussion (SAC): on-site mental status evaluation of the athlete. J Head Trauma Rehabil. 1998;13:27–35.PubMedCrossRef
41.
Zurück zum Zitat McCrea M, Kelly JP, Kluge J, et al. Standardized assessment of concussion in football players. Neurology. 1997;48:586–8.PubMedCrossRef McCrea M, Kelly JP, Kluge J, et al. Standardized assessment of concussion in football players. Neurology. 1997;48:586–8.PubMedCrossRef
42.
Zurück zum Zitat McCrea M. Standardized mental status testing on the sideline after sport-related concussion. J Athl Train. 2001;36:274–9.PubMed McCrea M. Standardized mental status testing on the sideline after sport-related concussion. J Athl Train. 2001;36:274–9.PubMed
43.
Zurück zum Zitat Valovich McLeod TC, Barr WB, McCrea M, Guskiewicz KM. Psychometric and measurement properties of concussion assessment tools in youth sports. J Athl Train. 2006;41:399–408.PubMed Valovich McLeod TC, Barr WB, McCrea M, Guskiewicz KM. Psychometric and measurement properties of concussion assessment tools in youth sports. J Athl Train. 2006;41:399–408.PubMed
44.
Zurück zum Zitat Valovich TC, Perrin DH, Gansneder BM. Repeat administration elicits a practice effect with the balance error scoring system but not with the standardized assessment of concussion in high school athletes. J Athl Train. 2003;38:51–6.PubMed Valovich TC, Perrin DH, Gansneder BM. Repeat administration elicits a practice effect with the balance error scoring system but not with the standardized assessment of concussion in high school athletes. J Athl Train. 2003;38:51–6.PubMed
45.
Zurück zum Zitat Grubenhoff JA, Kirkwood M, Gao D, Deakyne S, Wathen J. Evaluation of the standardized assessment of concussion in a pediatric emergency department. Pediatrics. 2010;126:688–95.PubMedCrossRef Grubenhoff JA, Kirkwood M, Gao D, Deakyne S, Wathen J. Evaluation of the standardized assessment of concussion in a pediatric emergency department. Pediatrics. 2010;126:688–95.PubMedCrossRef
46.
Zurück zum Zitat Galetta KM, Barrett J, Allen M, et al. The King-Devick test as a determinant of head trauma and concussion in boxers and MMA fighters. Neurology. 2011;76:1456–62.PubMedCrossRef Galetta KM, Barrett J, Allen M, et al. The King-Devick test as a determinant of head trauma and concussion in boxers and MMA fighters. Neurology. 2011;76:1456–62.PubMedCrossRef
47.
Zurück zum Zitat Heitger MH, Jones RD, Macleod AD, et al. Impaired eye movements in post-concussion syndrome indicate suboptimal brain function beyond the influence of depression, malingering or intellectual ability. Brain. 2010;133:2850–70. Heitger MH, Jones RD, Macleod AD, et al. Impaired eye movements in post-concussion syndrome indicate suboptimal brain function beyond the influence of depression, malingering or intellectual ability. Brain. 2010;133:2850–70.
48.
Zurück zum Zitat • Guskiewicz KM. Balance assessment in the management of sport-related concussion. Clin Sports Med. 2011;30:89–102. This provides background on balance deficits following mTBI and examines the BESS. PubMedCrossRef • Guskiewicz KM. Balance assessment in the management of sport-related concussion. Clin Sports Med. 2011;30:89–102. This provides background on balance deficits following mTBI and examines the BESS. PubMedCrossRef
49.
Zurück zum Zitat McCrea M, Guskiewicz KM, Marshall SW, et al. Acute effects and recovery time following concussion in collegiate football players: the NCAA Concussion Study. JAMA. 2003;290:2556–63.PubMedCrossRef McCrea M, Guskiewicz KM, Marshall SW, et al. Acute effects and recovery time following concussion in collegiate football players: the NCAA Concussion Study. JAMA. 2003;290:2556–63.PubMedCrossRef
50.
Zurück zum Zitat Guskiewicz KM, Ross SE, Marshall SW. Postural stability and neuropsychological deficits after concussion in collegiate athletes. J Athl Train. 2001;36:263–73.PubMed Guskiewicz KM, Ross SE, Marshall SW. Postural stability and neuropsychological deficits after concussion in collegiate athletes. J Athl Train. 2001;36:263–73.PubMed
51.
Zurück zum Zitat Riemann BL, Guskiewicz KM. Effects of mild head injury on postural stability as measured through clinical balance testing. J Athl Train. 2000;35:19–25.PubMed Riemann BL, Guskiewicz KM. Effects of mild head injury on postural stability as measured through clinical balance testing. J Athl Train. 2000;35:19–25.PubMed
52.
Zurück zum Zitat Broglio SP, Puetz TW. The effect of sport concussion on neurocognitive function, self-report symptoms and postural control: a meta-analysis. Sports Med. 2008;38:53–67.PubMedCrossRef Broglio SP, Puetz TW. The effect of sport concussion on neurocognitive function, self-report symptoms and postural control: a meta-analysis. Sports Med. 2008;38:53–67.PubMedCrossRef
53.
Zurück zum Zitat Finnoff JT, Peterson VJ, Hollman JH, Smith J. Intrarater and interrater reliability of the Balance Error Scoring System (BESS). PM&R. 2009;1:50–4.CrossRef Finnoff JT, Peterson VJ, Hollman JH, Smith J. Intrarater and interrater reliability of the Balance Error Scoring System (BESS). PM&R. 2009;1:50–4.CrossRef
54.
Zurück zum Zitat Susco TM, Valovich McLeod TC, Gansneder BM, et al. Balance recovers within 20 minutes after exertion as measured by the Balance Error Scoring System. J Athl Train. 2004;39:241–6.PubMed Susco TM, Valovich McLeod TC, Gansneder BM, et al. Balance recovers within 20 minutes after exertion as measured by the Balance Error Scoring System. J Athl Train. 2004;39:241–6.PubMed
55.
Zurück zum Zitat Wilkins JC, Valovich McLeod TC, Perrin DH, et al. Performance on the balance error scoring system decreases after fatigue. J Athl Train. 2004;39:156–61.PubMed Wilkins JC, Valovich McLeod TC, Perrin DH, et al. Performance on the balance error scoring system decreases after fatigue. J Athl Train. 2004;39:156–61.PubMed
56.
Zurück zum Zitat Bressel E, Yonker JC, Kras J, et al. Comparison of static and dynamic balance in female collegiate soccer, basketball, and gymnastics athletes. J Athl Train. 2007;42:42–6.PubMed Bressel E, Yonker JC, Kras J, et al. Comparison of static and dynamic balance in female collegiate soccer, basketball, and gymnastics athletes. J Athl Train. 2007;42:42–6.PubMed
57.
Zurück zum Zitat Docherty CL, Valovich-McLeod TC, Shultz SJ. Postural control deficits in participants with functional ankle instability as measured by the balance error scoring system. Clin J Sport Med. 2006;16:203–8.PubMedCrossRef Docherty CL, Valovich-McLeod TC, Shultz SJ. Postural control deficits in participants with functional ankle instability as measured by the balance error scoring system. Clin J Sport Med. 2006;16:203–8.PubMedCrossRef
58.
Zurück zum Zitat Valovich McLeod TC, Perrin DH, Guskiewicz KM, et al. Serial administration of clinical concussion assessments and learning effects in healthy young athletes. Clin J Sport Med. 2004;14:287–95.PubMedCrossRef Valovich McLeod TC, Perrin DH, Guskiewicz KM, et al. Serial administration of clinical concussion assessments and learning effects in healthy young athletes. Clin J Sport Med. 2004;14:287–95.PubMedCrossRef
59.
Zurück zum Zitat • Maerlender A, Flashman L, Kessler A, et al. Examination of the construct validity of ImPACT computerized test, traditional, and experimental neuropsychological measures. Clin Neuropsychol. 2010;24:1309–25. This analyzes the validity of the ImPACT test and emphasizes its role as a screening tool rather than an all-inclusive concussion management tool. PubMed • Maerlender A, Flashman L, Kessler A, et al. Examination of the construct validity of ImPACT computerized test, traditional, and experimental neuropsychological measures. Clin Neuropsychol. 2010;24:1309–25. This analyzes the validity of the ImPACT test and emphasizes its role as a screening tool rather than an all-inclusive concussion management tool. PubMed
60.
Zurück zum Zitat Iverson GL, Lovell MR, Collins MW. Interpreting change on ImPACT following sport concussion. Clin Neuropsychol. 2003;17:460–7.PubMed Iverson GL, Lovell MR, Collins MW. Interpreting change on ImPACT following sport concussion. Clin Neuropsychol. 2003;17:460–7.PubMed
61.
Zurück zum Zitat Randolph C. Baseline neuropsychological testing in managing sport-related concussion: does it modify risk? Curr Sports Med Rep. 2011;10:21–6.PubMed Randolph C. Baseline neuropsychological testing in managing sport-related concussion: does it modify risk? Curr Sports Med Rep. 2011;10:21–6.PubMed
62.
Zurück zum Zitat Broglio SP, Ferrara MS, Macciocchi SN, et al. Test-retest reliability of computerized concussion assessment programs. J Athl Train. 2007;42:509–14.PubMed Broglio SP, Ferrara MS, Macciocchi SN, et al. Test-retest reliability of computerized concussion assessment programs. J Athl Train. 2007;42:509–14.PubMed
63.
Zurück zum Zitat Van Kampen DA, Lovell MR, Pardini JE, et al. The "value added" of neurocognitive testing after sports-related concussion. Am J Sports Med. 2006;34:1630–5.PubMedCrossRef Van Kampen DA, Lovell MR, Pardini JE, et al. The "value added" of neurocognitive testing after sports-related concussion. Am J Sports Med. 2006;34:1630–5.PubMedCrossRef
64.
Zurück zum Zitat Collie A, Makdissi M, Maruff P, Bennell K, McCrory P. Cognition in the days following concussion: comparison of symptomatic versus asymptomatic athletes. J Neurol Neurosurg Psychiatry. 2006;77:241–5.PubMedCrossRef Collie A, Makdissi M, Maruff P, Bennell K, McCrory P. Cognition in the days following concussion: comparison of symptomatic versus asymptomatic athletes. J Neurol Neurosurg Psychiatry. 2006;77:241–5.PubMedCrossRef
65.
Zurück zum Zitat Makdissi M, Darby D, Maruff P, Ugoni A, Brukner P, McCrory PR. Natural history of concussion in sport: markers of severity and implications for management. Am J Sports Med. 2010;38:464–71.PubMedCrossRef Makdissi M, Darby D, Maruff P, Ugoni A, Brukner P, McCrory PR. Natural history of concussion in sport: markers of severity and implications for management. Am J Sports Med. 2010;38:464–71.PubMedCrossRef
66.
Zurück zum Zitat Maruff P, Thomas E, Cysique L, Brew B, Collie A, Snyder P, et al. Validity of the CogState brief battery: relationship to standardized tests and sensitivity to cognitive impairment in mild traumatic brain injury, schizophrenia, and AIDS dementia complex. Arch Clin Neuropsychol. 2009;24:165–78.PubMedCrossRef Maruff P, Thomas E, Cysique L, Brew B, Collie A, Snyder P, et al. Validity of the CogState brief battery: relationship to standardized tests and sensitivity to cognitive impairment in mild traumatic brain injury, schizophrenia, and AIDS dementia complex. Arch Clin Neuropsychol. 2009;24:165–78.PubMedCrossRef
67.
Zurück zum Zitat Moriarity J, Collie A, Olson D, Buchanan J, Leary P, McStephen M, et al. A prospective controlled study of cognitive function during an amateur boxing tournament. Neurology. 2004;62:1497–502.PubMedCrossRef Moriarity J, Collie A, Olson D, Buchanan J, Leary P, McStephen M, et al. A prospective controlled study of cognitive function during an amateur boxing tournament. Neurology. 2004;62:1497–502.PubMedCrossRef
68.
Zurück zum Zitat Straume-Naesheim TM, Andersen TE, Bahr R. Reproducibility of computer based neuropsychological testing among Norwegian elite football players. Br J Sports Med. 2005;39 Suppl 1:i64–9.PubMedCrossRef Straume-Naesheim TM, Andersen TE, Bahr R. Reproducibility of computer based neuropsychological testing among Norwegian elite football players. Br J Sports Med. 2005;39 Suppl 1:i64–9.PubMedCrossRef
69.
Zurück zum Zitat Straume-Naesheim TM, Andersen TE, Holme IMK, McIntosh AS, Dvorak J, Bahr R. Do minor head impacts in soccer cause concussive injury? A prospective case–control study. Neurosurgery. 2009;64:719–25.PubMedCrossRef Straume-Naesheim TM, Andersen TE, Holme IMK, McIntosh AS, Dvorak J, Bahr R. Do minor head impacts in soccer cause concussive injury? A prospective case–control study. Neurosurgery. 2009;64:719–25.PubMedCrossRef
70.
Zurück zum Zitat Cernich A, Reeves D, Sun W, Bleiberg J. Automated neuropsychological assessment metrics sports medicine battery. Arch Clin Neuropsychol. 2007;22 Suppl 1:S101–14.PubMedCrossRef Cernich A, Reeves D, Sun W, Bleiberg J. Automated neuropsychological assessment metrics sports medicine battery. Arch Clin Neuropsychol. 2007;22 Suppl 1:S101–14.PubMedCrossRef
71.
Zurück zum Zitat Bleiberg J, Kane RL, Reeves DL, Garmoe WS, Halpern E. Factor analysis of computerized and traditional tests used in mild brain injury research. Clin Neuropsychol. 2000;14:287–94.PubMed Bleiberg J, Kane RL, Reeves DL, Garmoe WS, Halpern E. Factor analysis of computerized and traditional tests used in mild brain injury research. Clin Neuropsychol. 2000;14:287–94.PubMed
72.
Zurück zum Zitat Pulsipher DT, Campbell RA, Thoma R, King JH. A critical review of neuroimaging applications in sports concussion. Curr Sports Med Rep. 2011;10:14–20.PubMed Pulsipher DT, Campbell RA, Thoma R, King JH. A critical review of neuroimaging applications in sports concussion. Curr Sports Med Rep. 2011;10:14–20.PubMed
73.
Zurück zum Zitat Zimmerman RA, Bilaniuk LT, Hackney DB, et al. Head injury: early results of comparing CT and high-field MR. Am J Roentgenol. 1986;147:1215–22. Zimmerman RA, Bilaniuk LT, Hackney DB, et al. Head injury: early results of comparing CT and high-field MR. Am J Roentgenol. 1986;147:1215–22.
74.
Zurück zum Zitat Nandigam RN, Viswanathan A, Delgado P, et al. MR imaging detection of cerebral microbleeds: effect of susceptibility-weighted imaging, section thickness, and field strength. Am J Neuroradiol. 2009;30:338–43.PubMedCrossRef Nandigam RN, Viswanathan A, Delgado P, et al. MR imaging detection of cerebral microbleeds: effect of susceptibility-weighted imaging, section thickness, and field strength. Am J Neuroradiol. 2009;30:338–43.PubMedCrossRef
75.
Zurück zum Zitat Maruta J, Lee SW, Jacobs EF, Ghajar J. A unified science of concussion. Ann NY Acad Sci. 2010;1208:58–66.PubMedCrossRef Maruta J, Lee SW, Jacobs EF, Ghajar J. A unified science of concussion. Ann NY Acad Sci. 2010;1208:58–66.PubMedCrossRef
76.
Zurück zum Zitat Davis GA, Iverson GL, Guskiewicz KM, et al. Contributions of neuroimaging, balance testing, electrophysiology and blood markers to the assessment of sport-related concussion. Br J Sports Med. 2009;43 Suppl 1:i36–45.PubMedCrossRef Davis GA, Iverson GL, Guskiewicz KM, et al. Contributions of neuroimaging, balance testing, electrophysiology and blood markers to the assessment of sport-related concussion. Br J Sports Med. 2009;43 Suppl 1:i36–45.PubMedCrossRef
77.
Zurück zum Zitat Cubon VA, Putukian M, Boyer C, Dettwiler A. A diffusion tensor imaging study on the white matter skeleton in individuals with sports-related concussion. J Neurotrauma. 2011;28:189–201.PubMedCrossRef Cubon VA, Putukian M, Boyer C, Dettwiler A. A diffusion tensor imaging study on the white matter skeleton in individuals with sports-related concussion. J Neurotrauma. 2011;28:189–201.PubMedCrossRef
78.
Zurück zum Zitat Slobounov SM, Gay M, Zhang K, et al. Alteration of brain functional network at rest and in response to YMCA physical stress test in concussed athletes: RsFMRI study. Neuroimage. 2011;55:1716–27.PubMedCrossRef Slobounov SM, Gay M, Zhang K, et al. Alteration of brain functional network at rest and in response to YMCA physical stress test in concussed athletes: RsFMRI study. Neuroimage. 2011;55:1716–27.PubMedCrossRef
79.
Zurück zum Zitat Alexander AL, Lee JE, Lazar M, Field AS. Diffusion tensor imaging of the brain. Neurotherapeutics. 2007;4:316–29.PubMedCrossRef Alexander AL, Lee JE, Lazar M, Field AS. Diffusion tensor imaging of the brain. Neurotherapeutics. 2007;4:316–29.PubMedCrossRef
80.
Zurück zum Zitat Fitzgerald DB, Crosson BA. Diffusion weighted imaging and neuropsychological correlates in adults with mild traumatic brain injury. Int J Psychophysiol. 2011;82:79–85.PubMedCrossRef Fitzgerald DB, Crosson BA. Diffusion weighted imaging and neuropsychological correlates in adults with mild traumatic brain injury. Int J Psychophysiol. 2011;82:79–85.PubMedCrossRef
81.
Zurück zum Zitat LeBihan D, Mangin JF, Poupon C, et al. Diffusion tensor imaging: concepts and applications. Magn Reson Imaging. 2001;13:534–46.CrossRef LeBihan D, Mangin JF, Poupon C, et al. Diffusion tensor imaging: concepts and applications. Magn Reson Imaging. 2001;13:534–46.CrossRef
82.
Zurück zum Zitat •• Prabhu SP. The role of neuroimaging in sport-related concussion. Clin Sports Med. 2011;30:103–14. This provides an in-depth investigation of neuroimaging tools, with a focus on the use of advanced functional imaging techniques in sports concussion. PubMedCrossRef •• Prabhu SP. The role of neuroimaging in sport-related concussion. Clin Sports Med. 2011;30:103–14. This provides an in-depth investigation of neuroimaging tools, with a focus on the use of advanced functional imaging techniques in sports concussion. PubMedCrossRef
83.
Zurück zum Zitat Pfefferbaum A, Sullivan EV, Hedehus M, et al. Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging. Magn Reson Med. 2000;44:259–68.PubMedCrossRef Pfefferbaum A, Sullivan EV, Hedehus M, et al. Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging. Magn Reson Med. 2000;44:259–68.PubMedCrossRef
84.
Zurück zum Zitat Smits M, Houston GC, Dippel DW, et al. Microstructural brain injury in post-concussion syndrome after minor head injury. Neuroradiology. 2011;53:553–63.PubMedCrossRef Smits M, Houston GC, Dippel DW, et al. Microstructural brain injury in post-concussion syndrome after minor head injury. Neuroradiology. 2011;53:553–63.PubMedCrossRef
85.
Zurück zum Zitat Kennedy MR, Wozniak JR, Muetzel RL, et al. White matter and neurocognitive changes in adults with chronic traumatic brain injury. J Int Neuropsychol Soc. 2009;15:130–6.PubMedCrossRef Kennedy MR, Wozniak JR, Muetzel RL, et al. White matter and neurocognitive changes in adults with chronic traumatic brain injury. J Int Neuropsychol Soc. 2009;15:130–6.PubMedCrossRef
86.
Zurück zum Zitat Kinnunen KM, Greenwood R, Powell JH, et al. White matter damage and cognitive impairment after traumatic brain injury. Brain. 2011;134:449–63.PubMedCrossRef Kinnunen KM, Greenwood R, Powell JH, et al. White matter damage and cognitive impairment after traumatic brain injury. Brain. 2011;134:449–63.PubMedCrossRef
87.
Zurück zum Zitat McAllister TW, Saykin AJ, Flashman LA, et al. Brain activation during working memory 1 month after mild traumatic brain injury: a functional MRI study. Neurology. 1999;53:1300–8.PubMedCrossRef McAllister TW, Saykin AJ, Flashman LA, et al. Brain activation during working memory 1 month after mild traumatic brain injury: a functional MRI study. Neurology. 1999;53:1300–8.PubMedCrossRef
88.
Zurück zum Zitat McAllister TW, Sparling MB, Flashman LA, Guerin SJ, Mamourian AC, Saykin AJ. Differential working memory load effects after mild traumatic brain injury. Neuroimage. 2001;14:1004–12.PubMedCrossRef McAllister TW, Sparling MB, Flashman LA, Guerin SJ, Mamourian AC, Saykin AJ. Differential working memory load effects after mild traumatic brain injury. Neuroimage. 2001;14:1004–12.PubMedCrossRef
89.
Zurück zum Zitat Chen JK, Johnston KM, Petrides M, Ptito A. Recovery from mild head injury in sports: evidence from serial functional magnetic resonance imaging studies in male athletes. Clin J Sport Med. 2008;18:241–7.PubMedCrossRef Chen JK, Johnston KM, Petrides M, Ptito A. Recovery from mild head injury in sports: evidence from serial functional magnetic resonance imaging studies in male athletes. Clin J Sport Med. 2008;18:241–7.PubMedCrossRef
90.
Zurück zum Zitat Chen JK, Johnston KM, Frey S, Petrides M, Worsley K, Ptito A. Functional abnormalities in symptomatic concussed athletes: an fMRI study. Neuroimage. 2004;22:68–82.PubMedCrossRef Chen JK, Johnston KM, Frey S, Petrides M, Worsley K, Ptito A. Functional abnormalities in symptomatic concussed athletes: an fMRI study. Neuroimage. 2004;22:68–82.PubMedCrossRef
91.
Zurück zum Zitat Jantzen KJ, Anderson B, Steinberg FL, Kelso JA. A prospective functional MR imaging study of mild traumatic brain injury in college football players. AJNR Am J Neuroradiol. 2004;25:738–45.PubMed Jantzen KJ, Anderson B, Steinberg FL, Kelso JA. A prospective functional MR imaging study of mild traumatic brain injury in college football players. AJNR Am J Neuroradiol. 2004;25:738–45.PubMed
92.
Zurück zum Zitat Slobounov SM, Zhang K, Pennell D, Ray W, Johnson B, Sebastianelli W. Functional abnormalities in normally appearing athletes following mild traumatic brain injury: a functional MRI study. Experimental Brain Research Experimentelle Hirnforschung Experimentation Cerebrale. 2010;202:341–54.PubMedCrossRef Slobounov SM, Zhang K, Pennell D, Ray W, Johnson B, Sebastianelli W. Functional abnormalities in normally appearing athletes following mild traumatic brain injury: a functional MRI study. Experimental Brain Research Experimentelle Hirnforschung Experimentation Cerebrale. 2010;202:341–54.PubMedCrossRef
93.
Zurück zum Zitat Chen JK, Johnston KM, Petrides M, Ptito A. Recovery from mild head injury in sports: evidence from serial functional magnetic resonance imaging studies in male athletes. Clin J Sport Med. 2008;18:241–7.PubMedCrossRef Chen JK, Johnston KM, Petrides M, Ptito A. Recovery from mild head injury in sports: evidence from serial functional magnetic resonance imaging studies in male athletes. Clin J Sport Med. 2008;18:241–7.PubMedCrossRef
94.
Zurück zum Zitat Chen JK, Johnston KM, Frey S, Petrides M, Worsley K, Ptito A. Functional abnormalities in symptomatic concussed athletes: an fMRI study. Neuroimage. 2004;22:68–82.PubMedCrossRef Chen JK, Johnston KM, Frey S, Petrides M, Worsley K, Ptito A. Functional abnormalities in symptomatic concussed athletes: an fMRI study. Neuroimage. 2004;22:68–82.PubMedCrossRef
95.
Zurück zum Zitat Pardini JE, Pardini DA, Becker JT, et al. Postconcussive symptoms are associated with compensatory cortical recruitment during a working memory task. Neurosurgery. 2010;67:1020–7.PubMedCrossRef Pardini JE, Pardini DA, Becker JT, et al. Postconcussive symptoms are associated with compensatory cortical recruitment during a working memory task. Neurosurgery. 2010;67:1020–7.PubMedCrossRef
96.
Zurück zum Zitat Lovell MR, Pardini JE, Welling JS, et al. Functional brain abnormalities are related to clinical recovery and time to return to play in athletes. Neurosurgery. 2007;61:352–60.PubMedCrossRef Lovell MR, Pardini JE, Welling JS, et al. Functional brain abnormalities are related to clinical recovery and time to return to play in athletes. Neurosurgery. 2007;61:352–60.PubMedCrossRef
97.
98.
Zurück zum Zitat Aguirre GK, Zarahn E, D'Esposito M. The variability of human, BOLD hemodynamic responses. Neuroimage. 1998;8:360–9.PubMedCrossRef Aguirre GK, Zarahn E, D'Esposito M. The variability of human, BOLD hemodynamic responses. Neuroimage. 1998;8:360–9.PubMedCrossRef
99.
Zurück zum Zitat Alessandri B, Doppenberg E, Zauner A, et al. Evidence for time-dependent glutamate-mediated glycolysis in head-injured patients: a microdialysis study. Acta Neurochir Suppl. 1999;75:25–30.PubMedCrossRef Alessandri B, Doppenberg E, Zauner A, et al. Evidence for time-dependent glutamate-mediated glycolysis in head-injured patients: a microdialysis study. Acta Neurochir Suppl. 1999;75:25–30.PubMedCrossRef
100.
Zurück zum Zitat Gasparovic C, Yeo R, Mannell M, et al. Neurometabolite concentrations in gray and white matter in mild traumatic brain injury: a 1 H-magnetic resonance spectroscopy study. J Neurotrauma. 2009;26:1635–43.PubMedCrossRef Gasparovic C, Yeo R, Mannell M, et al. Neurometabolite concentrations in gray and white matter in mild traumatic brain injury: a 1 H-magnetic resonance spectroscopy study. J Neurotrauma. 2009;26:1635–43.PubMedCrossRef
101.
Zurück zum Zitat Vagnozzi R, Signoretti S, Cristofori L, et al. Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients. Brain. 2010;133:3232–42.PubMedCrossRef Vagnozzi R, Signoretti S, Cristofori L, et al. Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients. Brain. 2010;133:3232–42.PubMedCrossRef
102.
Zurück zum Zitat Peskind ER, Petrie EC, Cross DJ, et al. Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms. Neuroimage. 2011;54 Suppl 1:S76–82.PubMedCrossRef Peskind ER, Petrie EC, Cross DJ, et al. Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms. Neuroimage. 2011;54 Suppl 1:S76–82.PubMedCrossRef
103.
Zurück zum Zitat Newberg AB, Alavi A. Neuroimaging in patients with head injury. Semin Nucl Med. 2003;33:136–47.PubMedCrossRef Newberg AB, Alavi A. Neuroimaging in patients with head injury. Semin Nucl Med. 2003;33:136–47.PubMedCrossRef
104.
Zurück zum Zitat Langfitt TW, Obrist WD, Alavi A, et al. Computerized tomography, magnetic resonance imaging, and positron emission tomography in the study of brain trauma. J Neurosurg. 1986;64:760–7.PubMedCrossRef Langfitt TW, Obrist WD, Alavi A, et al. Computerized tomography, magnetic resonance imaging, and positron emission tomography in the study of brain trauma. J Neurosurg. 1986;64:760–7.PubMedCrossRef
105.
Zurück zum Zitat Abdel-Dayem HM, Abu-Judeh H, Kumar M, et al. SPECT brain perfusion abnormalities in mild or moderate traumatic brain injury. Clin Nucl Med. 1998;23:309.PubMedCrossRef Abdel-Dayem HM, Abu-Judeh H, Kumar M, et al. SPECT brain perfusion abnormalities in mild or moderate traumatic brain injury. Clin Nucl Med. 1998;23:309.PubMedCrossRef
106.
Zurück zum Zitat Shiina G, Onuma T, Kameyama M, et al. Sequential assessment of cerebral blood flow in diffuse brain injury by 123I-iodoamphetamine single-photon emission CT. Am J Neuroradiol. 1998;19:297–302.PubMed Shiina G, Onuma T, Kameyama M, et al. Sequential assessment of cerebral blood flow in diffuse brain injury by 123I-iodoamphetamine single-photon emission CT. Am J Neuroradiol. 1998;19:297–302.PubMed
107.
Zurück zum Zitat Abu-Judeh HH, Singh M, Masdeu JC, Abdel-Dayem HM. Discordance between FDG uptake and technetium-99 m-HMPAO brain perfusion in acute traumatic brain injury. J Nucl Med. 1998;39:1357.PubMed Abu-Judeh HH, Singh M, Masdeu JC, Abdel-Dayem HM. Discordance between FDG uptake and technetium-99 m-HMPAO brain perfusion in acute traumatic brain injury. J Nucl Med. 1998;39:1357.PubMed
108.
Zurück zum Zitat Topolovec VJ, Pollmann-Mudryj MA, Ouchterlony D, et al. The value of serum biomarkers in prediction models of outcome after mild traumatic brain injury. J Trauma. 2011;71:S478–86.CrossRef Topolovec VJ, Pollmann-Mudryj MA, Ouchterlony D, et al. The value of serum biomarkers in prediction models of outcome after mild traumatic brain injury. J Trauma. 2011;71:S478–86.CrossRef
109.
Zurück zum Zitat Townend W, Ingebrigtsen T. Head injury outcome prediction: a role for protein S-100B? Injury. 2006;37:1098–108.PubMedCrossRef Townend W, Ingebrigtsen T. Head injury outcome prediction: a role for protein S-100B? Injury. 2006;37:1098–108.PubMedCrossRef
110.
Zurück zum Zitat Sawauchi S, Taya K, Murakami S, et al. Serum S-100B protein and neuron-specific enolase after traumatic brain injury. No Shinkei Geka. 2005;33:1073–80.PubMed Sawauchi S, Taya K, Murakami S, et al. Serum S-100B protein and neuron-specific enolase after traumatic brain injury. No Shinkei Geka. 2005;33:1073–80.PubMed
111.
Zurück zum Zitat Stålnacke BM, Björnstig U, Karlsson K, Sojka P. One-year follow-up of mild traumatic brain injury: post-concussion symptoms, disabilities and life satisfaction in relation to serum levels of S-100B and neurone-specific enolase in acute phase. J Rehabil Med. 2005;37:300–5.PubMedCrossRef Stålnacke BM, Björnstig U, Karlsson K, Sojka P. One-year follow-up of mild traumatic brain injury: post-concussion symptoms, disabilities and life satisfaction in relation to serum levels of S-100B and neurone-specific enolase in acute phase. J Rehabil Med. 2005;37:300–5.PubMedCrossRef
112.
Zurück zum Zitat Kleinert K, Schleich F, Biasca N, Simmen HP. [Is there a correlation between S100 beta and post-concussion symptoms after mild traumatic brain injury?]. Zentralbl Chir. 2010;135:277–8.PubMedCrossRef Kleinert K, Schleich F, Biasca N, Simmen HP. [Is there a correlation between S100 beta and post-concussion symptoms after mild traumatic brain injury?]. Zentralbl Chir. 2010;135:277–8.PubMedCrossRef
113.
Zurück zum Zitat Begaz T, Kyriacou DN, Segal J, Bazarian JJ. Serum biochemical markers for post-concussion syndrome in patients with mild traumatic brain injury. J Neurotrauma. 2006;23:1201–10.PubMedCrossRef Begaz T, Kyriacou DN, Segal J, Bazarian JJ. Serum biochemical markers for post-concussion syndrome in patients with mild traumatic brain injury. J Neurotrauma. 2006;23:1201–10.PubMedCrossRef
114.
Zurück zum Zitat Bazarian JJ, Zemlan FP, Mookerjee S, Stigbrand T. Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury. Brain Inj. 2006;20:759–65.PubMedCrossRef Bazarian JJ, Zemlan FP, Mookerjee S, Stigbrand T. Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury. Brain Inj. 2006;20:759–65.PubMedCrossRef
115.
Zurück zum Zitat de Boussard CN, Lundin A, Karlstedt D, et al. S100 and cognitive impairment after mild traumatic brain injury. J Rehabil Med. 2005;37:53–7.PubMedCrossRef de Boussard CN, Lundin A, Karlstedt D, et al. S100 and cognitive impairment after mild traumatic brain injury. J Rehabil Med. 2005;37:53–7.PubMedCrossRef
116.
Zurück zum Zitat Zhou W, Xu D, Peng X, et al. Meta-analysis of APOE4 allele and outcome after traumatic brain injury. J Neurotrauma. 2008;25:279–90.PubMedCrossRef Zhou W, Xu D, Peng X, et al. Meta-analysis of APOE4 allele and outcome after traumatic brain injury. J Neurotrauma. 2008;25:279–90.PubMedCrossRef
117.
Zurück zum Zitat Kristman VL, Tator CH, Kreiger N, et al. Does the apolipoprotein epsilon 4 allele predispose varsity athletes to concussion? A prospective cohort study. Clin J Sport Med. 2008;18:322–8.PubMedCrossRef Kristman VL, Tator CH, Kreiger N, et al. Does the apolipoprotein epsilon 4 allele predispose varsity athletes to concussion? A prospective cohort study. Clin J Sport Med. 2008;18:322–8.PubMedCrossRef
118.
Zurück zum Zitat Tierney RT, Mansell JL, Higgins M. Apolipoprotein E genotype and concussion in college athletes. Clin J Sport Med. 2010;20:464–8.PubMedCrossRef Tierney RT, Mansell JL, Higgins M. Apolipoprotein E genotype and concussion in college athletes. Clin J Sport Med. 2010;20:464–8.PubMedCrossRef
119.
Zurück zum Zitat McCrory P, Meeuwisse W, Johnston K, et al. Consensus statement on Concussion in Sport 3rd International Conference on Concussion in Sport held in Zurich, November 2008. Clin J Sport Med. 2009;19:185–200.PubMedCrossRef McCrory P, Meeuwisse W, Johnston K, et al. Consensus statement on Concussion in Sport 3rd International Conference on Concussion in Sport held in Zurich, November 2008. Clin J Sport Med. 2009;19:185–200.PubMedCrossRef
Metadaten
Titel
Sports-Related Concussion Testing
verfasst von
Mark S. Dziemianowicz
Matthew P. Kirschen
Bryan A. Pukenas
Eric Laudano
Laura J. Balcer
Steven L. Galetta
Publikationsdatum
01.10.2012
Verlag
Current Science Inc.
Erschienen in
Current Neurology and Neuroscience Reports / Ausgabe 5/2012
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-012-0299-y

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