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Current Rheumatology Reports
Erschienen in: Current Rheumatology Reports 3/2010

01.06.2010

Dermatomyositis and Type 1 Interferons

verfasst von: Steven A. Greenberg

Erschienen in: Current Rheumatology Reports | Ausgabe 3/2010

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Abstract

Dermatomyositis is a poorly understood multisystem disease predominantly affecting skin and muscle. This review focuses on the potential role of a group of related cytokines, the type 1 interferons, in the pathogenesis of dermatomyositis. Type 1 interferon–inducible transcripts and proteins are uniquely elevated in dermatomyositis muscle compared with all other muscle diseases studied to date. The endothelial cell tubuloreticular inclusions present in affected dermatomyositis muscle are biomarkers of type 1 interferon exposure. The cell-poor lichenoid reaction in skin with predominant involvement of the basal epidermal cell layer and its topologic equivalent in muscle, perifascicular atrophy, may be lesions that develop directly in response to type 1 interferon signaling.
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Metadaten
Titel
Dermatomyositis and Type 1 Interferons
verfasst von
Steven A. Greenberg
Publikationsdatum
01.06.2010
Verlag
Current Science Inc.
Erschienen in
Current Rheumatology Reports / Ausgabe 3/2010
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-010-0101-6

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