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Hair follicles: gatekeepers to the epidermis

Substantial depletion of Langerhans cells leads to their replenishment by bone marrow–derived precursors that access the epidermis through hair follicles, a site of crucial chemokine production.

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Figure 1: Chemokines produced by hair follicles affect the recruitment of precursor cells after depletion of Langerhans cells.

Katie Vicari

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Correspondence to William R Heath or Scott N Mueller.

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Heath, W., Mueller, S. Hair follicles: gatekeepers to the epidermis. Nat Immunol 13, 715–717 (2012). https://doi.org/10.1038/ni.2374

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