Erschienen in:
01.12.2009 | Short communication
Gene expression profiling of breast cancer
verfasst von:
Lajos Pusztai
Erschienen in:
Breast Cancer Research
|
Sonderheft 3/2009
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Excerpt
Important differences in the clinical behaviour of oestrogen receptor (ER)-positive and ER-negative cancers have been recognised for a long time [
1]. Nevertheless, breast cancer was regarded as a single disease with variable histology and clinical course. More recently, high-throughput analytical methods revealed unexpectedly large-scale molecular differences between ER-positive cancers and ER-negative cancers [
2]. These results prompted a conceptual shift in the classification of breast cancer, which is increasingly viewed not as a single disease but as a collection of several biologically distinct neoplastic diseases that arise from the breast epithelium. …