nach oben

Drug Safety

Erschienen in:

01.10.2011 | Review Article

Drug-Induced Photosensitivity

Culprit Drugs, Management and Prevention

verfasst von: Aaron M. Drucker, Dr Cheryl F. Rosen

Erschienen in: Drug Safety | Ausgabe 10/2011

Einloggen, um Zugang zu erhalten

Abstract

Photo-induced drug eruptions are cutaneous adverse events due to exposure to a drug and either ultraviolet or visible radiation. Based on their pathogenesis, they can be classified as phototoxic or photoallergic drug eruptions, although in many cases it is not possible to determine whether a particular eruption is due to a phototoxic or photoallergic mechanism.

In this review, the diagnosis, prevention and management of drug-induced photosensitivity are discussed. Diagnosis is based primarily on the history of drug intake and the clinical appearance of the eruption, primarily affecting sun-exposed areas of the skin. Phototesting and photopatch testing can be useful adjuncts in making a diagnosis. The mainstay of management is prevention, including informing patients of the possibility of increased sun sensitivity and the use of sun protective measures. However, once the eruption has occurred, it may be necessary to discontinue the culprit medication and treat the eruption with a potent topical corticosteroid. Drugs that have been implicated in causing photosensitive eruptions are reviewed. Tetracycline, doxycycline, nalidixic acid, voriconazole, amiodarone, hydrochlorothiazide, naproxen, piroxicam, chlorpromazine and thioridazine are among the most commonly implicated medications. We review the medical literature regarding evidence for the culpability of each drug, including the results of phototesting, photopatch testing and rechallenge testing.

Selvaag E. Clinical drug photosensitivity: a retrospective analysis of reports to the Norwegian Adverse Drug Reactions Committee from the years 1970–1994. Photodermatol Photoimmunol Photomed 1997 Feb–Apr; 13(1–2): 21–3PubMed

Willis I, Kligman AM. The mechanism of photoallergic contact dermatitis. J Invest Dermatol 1968 Nov; 51(5): 378–84PubMed

Bolognia J, Jorizzo JL, Rapini RP. Dermatology. 2nd ed. St Louis (MO), London: Mosby Elsevier, 2008

Spielmann H, Balls M, Brand M, et al. EEC/COLIPA project on in vitro phototoxicity testing: first results obtained with a Balb/c 3T3 cell phototoxicity assay. Toxicol In Vitro 1994 Aug; 8(4): 793–6PubMed

Traynor NJ, Barratt MD, Lovell WW, et al. Comparison of an in vitro cellular phototoxicity model against controlled clinical trials of fluoroquinolone skin phototoxicity. Toxicol In Vitro 2000 Jun; 14(3): 275–83PubMed

DeLeo VA, Suarez SM, Maso MJ. Photoallergic contact dermatitis: results of photopatch testing in New York, 1985 to 1990. Arch Dermatol 1992 Nov; 128(11): 1513–8PubMed

Kerr A, Shareef M, Dawe R, et al. Photopatch testing negative in systemic quinine phototoxicity. Photodermatol Photoimmunol Photomed 2010 Jun; 26(3): 151–2PubMed

Moore DE. Drug-induced cutaneous photosensitivity: incidence, mechanism, prevention and management. Drug Saf 2002;25(5):345–72PubMed

Tanaka N, Kawada A, Ohnishi Y, et al. Photosensitivity due to doxycycline hydrochloride with an unusual flare. Contact Dermatitis 1997 Aug; 37(2): 93–4PubMed

10.

Ramsay CA, Obreshkova E. Photosensitivity from nalidixic acid. Br J Dermatol 1974 Nov; 91(5): 523–8PubMed

11.

Ferguson J, Johnson BE. Ciprofloxacin-induced photosensitivity: in vitro and in vivo studies. Br J Dermatol 1990 Jul; 123(1): 9–20PubMed

12.

Tokura Y, Iwamoto Y, Mizutani K, et al. Sparfloxacin phototoxicity: potential photoaugmentation by ultraviolet A and B sources. Arch Dermatol Res 1996; 288(1): 45–50PubMed

13.

Scheife RT, Cramer WR, Decker EL. Photosensitizing potential of ofloxacin. Int J Dermatol 1993 Jun; 32(6): 413–6PubMed

14.

Lee AY, Jung SY. Two patients with isoniazid-induced photosensitive lichenoid eruptions confirmed by photopatch test. Photodermatol Photoimmunol Photomed 1998 Apr; 14(2): 77–8PubMed

15.

Katiyar SK, Bihari S, Prakash S. Pyrazinamide-induced phototoxicity: a case report and review of literature. Indian J Dermatol 2010; 55(1): 113–5PubMed

16.

Borgia F, Vaccaro M, Guarneri F, et al. Photodistributed telangiectasia following use of cefotaxime. Br J Dermatol 2000 Sep; 143(3): 674–5PubMed

17.

Stockel S, Meurer M, Wozel G. Dapsone-induced photodermatitis in a patient with linear IgA dermatosis. Eur J Dermatol 2001 Jan–Feb; 11(1): 50–3PubMed

18.

De D, Dogra S, Kaur I. Dapsone induced acute photosensitivity dermatitis; a case report and review of literature. Lepr Rev 2007 Dec; 78(4): 401–4PubMed

19.

Kar BR. Dapsone-induced photosensitivity: a rare clinical presentation. Photodermatol Photoimmunol Photomed 2008 Oct; 24(5): 270–1PubMed

20.

Chandler MJ. Recurrence of phototoxic skin eruption due to trimethoprim [letter]. J Infect Dis 1986 May; 153(5): 1001PubMed

21.

Alvarez-Fernandez JG, Castano-Suarez E, Cornejo-Navarro P, et al. Photosensitivity induced by oral itraconazole. J Eur Acad Dermatol Venereol 2000 Nov; 14(6): 501–3PubMed

22.

Lang Jr PG. Quinidine-induced photodermatitis confirmed by photopatch testing. J Am Acad Dermatol 1983 Jul; 9(1): 124–8PubMed

23.

Armstrong RB, Leach EE, Whitman G, et al. Quinidine photosensitivity. Arch Dermatol 1985 Apr; 121(4): 525–8PubMed

24.

Ljunggren B, Hindsen M, Isaksson M. Systemic quinine photosensitivity with photoepicutaneous cross-reactivity to quinidine. Contact Dermatitis 1992 Jan; 26(1): 1–4PubMed

25.

Ferguson J, Addo HA, Johnson BE, et al. Quinine-induced photosensitivity: clinical and experimental studies. Br J Dermatol 1987 Nov; 117(5): 631–40PubMed

26.

Lisi P, Assalve D, Hansel K. Phototoxic and photoallergic dermatitis caused by hydroxychloroquine. Contact Dermatitis 2004 Apr; 50(4): 255–6PubMed

27.

Treudler R, Husak R, Raisova M, et al. Efavirenz-induced photoallergic dermatitis in HIV. AIDS 2001 May 25; 15(8): 1085–6PubMed

28.

Yoshimoto E, Konishi M, Takahashi K, et al. The first case of efavirenz-induced photosensitivity in a Japanese patient with HIV infection. Intern Med 2004 Jul; 43(7): 630–1PubMed

29.

Bergner T, Przybilla B. Photosensitization caused by ibuprofen. J Am Acad Dermatol 1992 Jan; 26(1): 114–6PubMed

30.

White IR. Photopatch test in a hydrochlorothiazide drug eruption [letter]. Contact Dermatitis 1983 May; 9(3): 237PubMed

31.

Addo HA, Ferguson J, Frain-Bell W. Thiazide-induced photosensitivity: a study of 33 subjects. Br J Dermatol 1987 Jun; 116(6): 749–60PubMed

32.

Heydenreich G, Pindborg T, Schmidt H. Bullous dermatosis among patients with chronic renal failure of high dose frusemide. Acta Med Scand 1977; 202(1–2): 61–4PubMed

33.

Fernandez de Corres L, Bernaola G, Fernandez E, et al. Photodermatitis from triamterene. Contact Dermatitis 1987 Aug; 17(2): 114–5PubMed

34.

Wagner SN, Welke F, Goos M. Occupational UVA-induced allergic photodermatitis in a welder due to hydrochlorothiazide and ramipril. Contact Dermatitis 2000 Oct; 43(4): 245–6PubMed

35.

Rodriguez Granados MT, Abalde T, Garcia Doval I, et al. Systemic photosensitivity to quinapril. J Eur Acad Dermatol Venereol 2004 May; 18(3): 389–90PubMed

36.

Collins P, Ferguson J. Photodistributed nifedipine-induced facial telangiectasia. Br J Dermatol 1993 Nov; 129(5): 630–3PubMed

37.

Zenarola P, Gatti S, Lomuto M. Photodermatitis due to nifedipine: report of 2cases. Dermatologica 1991; 182(3): 196–8PubMed

38.

Scherschun L, Lee MW, Lim HW. Diltiazem-associated photodistributed hyperpigmentation: a review of 4 cases. Arch Dermatol 2001 Feb; 137(2): 179–82PubMed

39.

Seggev JS, Lagstein Z. Photosensitivity skin reactions to calcium channel blockers. J Allergy Clin Immunol 1996 Mar; 97(3): 852–5PubMed

40.

Miyauchi H, Horiki S, Horio T. Clinical and experimental photosensitivity reaction to tilisolol hydrochloride. Photodermatol Photoimmunol Photomed 1994 Dec; 10(6): 255–8PubMed

41.

Mota AV, Vasconcelos C, Correia TM, et al. Rilmenidineinduced photosensitivity reaction. Photodermatol Photoimmunol Photomed 1998 Jun–Aug; 14(3-4): 132–3PubMed

42.

Vaillant L, Le Marchand D, Grognard C, et al. Photosensitivity to methyldopa. Arch Dermatol 1988 Mar; 124(3): 326–7PubMed

43.

Zachary CB, Slater DN, Holt DW, et al. The pathogenesis of amiodarone-induced pigmentation and photosensitivity. Br J Dermatol 1984 Apr; 110(4): 451–6PubMed

44.

Ferguson J, Addo HA, Jones S, et al. A study of cutaneous photosensitivity induced by amiodarone. Br J Dermatol 1985 Nov; 113(5): 537–49PubMed

45.

Matsuo I, Ozawa A, Niizuma K, et al. Lichenoid dermatitis due to chlorpromazine phototoxicity. Dermatologica 1979; 159(1): 46–9PubMed

46.

Raffle EJ, MacLeod TM, Hutchinson F, et al. Chlorpromazine photosensitivity [letter]. Arch Dermatol 1975 Oct; 111(10): 1364–5PubMed

47.

Rohrborn W, Brauninger W. Thioridazine photoallergy [letter]. Contact Dermatitis 1987 Oct; 17(4): 241PubMed

48.

Bourrain JL, Paillet C, Woodward C, et al. Diagnosis of photosensitivity to flupenthixol by photoprick testing. Photodermatol Photoimmunol Photomed 1997 Aug; 13(4): 159–61PubMed

49.

Ljunggren B, Bojs G. A case of photosensitivity and contact allergy to systemic tricyclic drugs, with unusual features. Contact Dermatitis 1991 Apr; 24(4): 259–65PubMed

50.

Vilaplana J, Botey E, Lecha M, et al. Photosensitivity induced by paroxetine. Contact Dermatitis 2002 Aug; 47(2): 118–9PubMed

51.

Doffoel-Hantz V, Boulitrop-Morvan C, Sparsa A, et al. Photosensitivity associated with selective serotonin reuptake inhibitors. Clin Exp Dermatol 2009 Dec; 34(8): e763–5PubMed

52.

Gillet-Terver MN, Modiano P, Trechot P, et al. Fluvoxamine photosensitivity [letter]. Australas J Dermatol 1996 Feb; 37(1): 62PubMed

53.

Vaccaro M, Borgia F, Barbuzza O, et al. Photodistributed eruptive telangiectasia: an uncommon adverse drug reaction to venlafaxine. Br J Dermatol 2007 Oct; 157(4): 822–4PubMed

54.

Watanabe Y, Kawada A, Ohnishi Y, et al. Photosensitivity due to alprazolam with positive oral photochallenge test after 17 days administration. J Am Acad Dermatol 1999 May; 40 (5 Pt 2): 832–3PubMed

55.

Luton EF, Finchum RN. Photosensitivity reaction to chlordiazepoxide. Arch Dermatol 1965 Apr; 91(4): 362–3

56.

Rodriguez-Pazos L, Sanchez-Aguilar D, Rodriguez-Granados MT, et al. Erythema multiforme photoinduced by statins. Photodermatol Photoimmunol Photomed 2010 Aug; 26(4): 216–8PubMed

57.

Granados MT, de la Torre C, Cruces MJ, et al. Chronic actinic dermatitis due to simvastatin. Contact Dermatitis 1998 May; 38(5): 294–5PubMed

58.

Marguery MC, Chouini-Lalanne N, Drugeon C, et al. UVB phototoxic effects induced by atorvastatin. Arch Dermatol 2006 Aug; 142(8): 1082–4PubMed

59.

Machet L, Vaillant L, Jan V, et al. Fenofibrate-induced photosensitivity: value of photopatch testing. J Am Acad Dermatol 1997 Nov; 37 (5 Pt 1): 808–9PubMed

60.

Horio T, Murai T, Ikai K. Photosensitivity due to a fluorouracil derivative. Arch Dermatol 1978 Oct; 114(10): 1498–500PubMed

61.

Usuki A, Funasaka Y, Oka M, et al. Tegafur-induced photosensitivity: evaluation of provocation by UVB irradiation. Int J Dermatol 1997 Aug; 36(8): 604–6PubMed

62.

Horio T, Yokoyama M. Tegaful photosensitivity: lichenoid and eczematous types. Photodermatol 1986 Jun; 3(3): 192–3PubMed

63.

Martin-Lazaro J, Bujan JG, Arrondo AP, et al. Is photopatch testing useful in the investigation of photosensitivity due to flutamide? Contact Dermatitis 2004 May; 50(5): 325–6PubMed

64.

Yokote R, Tokura Y, Igarashi N, et al. Photosensitive drug eruption induced by flutamide. Eur J Dermatol 1998 Sep; 8(6): 427–9PubMed

65.

Yung CW, Winston EM, Lorincz AL. Dacarbazineinduced photosensitivity reaction. J Am Acad Dermatol 1981 May; 4(5): 541–3PubMed

66.

Breza TS, Halprin KM, Taylor JR. Photosensitivity reaction to vinblastine. Arch Dermatol 1975 Sep; 111(9): 1168–70PubMed

67.

Balabanova MB. Photoprovoked erythematobullous eruption from farmorubicin. Contact Dermatitis 1994 May; 30(5): 303–4PubMed

68.

Ferguson J, Johnson BE. Retinoid associated phototoxicity and photosensitivity. Pharmacol Ther 1989; 40(1): 123–35PubMed

69.

Seishima M, Shibuya Y, Kato G, et al. Photoleukomelanoderma possibly caused by etretinate in a patient with psoriasis. Acta Derm Venereol 2010; 90(1): 85–6PubMed

70.

Gomez-Bernal S, Loureiro M, Rodriguez-Granados MT, et al. Systemic photosensitivity due to a contraceptive patch. Photodermatol Photoimmunol Photomed 2010 Aug; 26(4): 213–5PubMed

71.

Cooper SM, George S. Photosensitivity reaction associated with use of the combined oral contraceptive. Br J Dermatol 2001 Mar; 144(3): 641–2PubMed

72.

Kondo S, Kagaya M, Yamada Y, et al. UVB photosensitivity due to ranitidine. Dermatology 2000; 201(1): 71–3PubMed

73.

Horio T. Allergic and photoallergic dermatitis from diphenhydramine. Arch Dermatol 1976 Aug; 112(8): 1124–6PubMed

74.

Kim TH, Kang JS, Lee HS, et al. Two cases of mequitazineinduced photosensitivity reactions. Photodermatol Photoimmunol Photomed 1995 Aug; 11(4): 170–3PubMed

75.

Kurumaji Y, Shono M. Drug-induced solar urticaria due to repirinast. Dermatology 1994; 188(2): 117–21PubMed

76.

Yasuda S, Mizuno N, Kawabe Y, et al. Photosensitive lichenoid reaction accompanied by nonphotosensitive subacute prurigo caused by carbamazepine. Photodermatol 1988 Oct; 5(5): 206–10PubMed

77.

Sun CC. Photosensitivity due to glyburide. Photodermatol 1988 Feb; 5(1): 42–5PubMed

78.

Dogra S, Kanwar AJ. Clopidogrel bisulphate-induced photosensitive lichenoid eruption: first report. Br J Dermatol 2003 Mar; 148(3): 609–10PubMed

79.

Kestel Jr JL. Photo-onycholysis from minocycline: side effects of minocycline therapy. Cutis 1981 Jul; 28(1): 53–4PubMed

80.

Ibsen HH, Lasthein Andersen B. Photo-onycholysis due to tetracycline-hydrochloride. Acta Derm Venereol 1983; 63(6): 555–7PubMed

81.

Epstein JH, Seibert JS. Porphyria-like cutaneous changes induced by tetracycline hydrochloride photosensitization. Arch Dermatol 1976 May; 112(5): 661–6PubMed

82.

Yap LM, Foley PA, Crouch RB, et al. Drug-induced solar urticaria due to tetracycline. Australas J Dermatol 2000 Aug; 41(3): 181–4PubMed

83.

Henderson CA, Cunliffe WJ. Unusual side-effects in patients receiving doxycycline. J Dermatolog Treat 1989 Jan 1989; 1(2): 95–6

84.

Layton AM, Cunliffe WJ. Phototoxic eruptions due to doxycycline: a dose-related phenomenon. Clin Exp Dermatol 1993 Sep; 18(5): 425–7PubMed

85.

Yong CK, Prendiville J, Peacock DL, et al. An unusual presentation of doxycycline-induced photosensitivity. Pediatrics 2000 Jul; 106(1): E13PubMed

86.

Burry JN. Persistent phototoxicity due to nalidixic acid [letter]. Arch Dermatol 1974 Feb; 109(2): 263PubMed

87.

Birkett DA, Garretts M, Stevenson CJ. Phototoxic bullous eruptions due to nalidixic acid. Br J Dermatol 1969 May; 81(5): 342–4PubMed

88.

Mehlhorn AJ, Brown DA. Safety concerns with fluoroquinolones. Ann Pharmacother 2007 Nov; 41(11): 1859–66PubMed

89.

Urbina F, Barrios M, Sudy E. Photolocalized purpura during ciprofloxacin therapy. Photodermatol Photoimmunol Photomed 2006 Apr; 22(2): 111–2PubMed

90.

Burdge DR, Nakielna EM, Rabin HR. Photosensitivity associated with ciprofloxacin use in adult patients with cystic fibrosis [letter]. Antimicrob Agents Chemother 1995 Mar; 39(3): 793PubMed

91.

Jensen T, Pedersen SS, Nielsen CH, et al. The efficacy and safety of ciprofloxacin and ofloxacin in chronic Pseudomonas aeruginosa infection in cystic fibrosis. J Antimicrob Chemother 1987 Oct; 20(4): 585–94PubMed

92.

Hamanaka H, Mizutani H, Shimizu M. Sparfloxacininduced photosensitivity and the occurrence of a lichenoid tissue reaction after prolonged exposure. J Am Acad Dermatol 1998 Jun; 38 (6Pt 1): 945–9PubMed

93.

Mahajan VK, Sharma NL. Photo-onycholysis due to sparfloxacin. Australas J Dermatol 2005 May; 46(2): 104–5PubMed

94.

Dawe RS, Ibbotson SH, Sanderson JB, et al. A randomized controlled trial (volunteer study) of sitafloxacin, enoxacin, levofloxacin and sparfloxacin phototoxicity. Br J Dermatol 2003 Dec; 149(6): 1232–41PubMed

95.

Liu HH. Safety profile of the fluoroquinolones: focus on levofloxacin. Drug Saf 2010 May 1; 33(5): 353–69PubMed

96.

Man I, Murphy J, Ferguson J. Fluoroquinolone phototoxicity: a comparison of moxifloxacin and lomefloxacin in normal volunteers. J Antimicrob Chemother 1999 May; 43 Suppl. B: 77–82PubMed

97.

Van Bambeke F, Tulkens PM. Safety profile of the respiratory fluoroquinolone moxifloxacin: comparison with other fluoroquinolones and other antibacterial classes. Drug Saf 2009; 32(5): 359–78PubMed

98.

Baran R, Brun P. Photoonycholysis induced by the fluoroquinolones pefloxacine and ofloxacine: report on 2 cases. Dermatologica 1986; 173(4): 185–8PubMed

99.

Vinks SA, Heijerman HG, de Jonge P, et al. Photosensitivity due to ambulatory intravenous ceftazidime in cystic fibrosis patient. Lancet 1993 May 8; 341(8854): 1221–2PubMed

100.

Dhanapaul S. DDS-induced photosensitivity with reference to six case reports. Lepr Rev 1989 Jun; 60(2): 147–50PubMed

101.

Fumey SM. Dapsone-induced photodermatitis in a patient with leprosy. Z Hautkr 1988 Jan 18; 63(1): 53–4PubMed

102.

Joseph MS. Photodermatitis provoked by dapsone: a case report. Lepr Rev 1987 Dec; 58(4): 425–8PubMed

103.

Tolland JP, McKeown PP, Corbett JR. Voriconazoleinduced pseudoporphyria. Photodermatol Photoimmunol Photomed 2007 Feb; 23(1): 29–31PubMed

104.

Rubenstein M, Levy ML, Metry D. Voriconazole-induced retinoid-like photosensitivity in children. Pediatr Dermatol 2004 Nov–Dec; 21(6): 675–8PubMed

105.

Racette AJ, Roenigk Jr HH, Hansen R, et al. Photoaging and phototoxicity from long-term voriconazole treatment in a 15-year-old girl. J Am Acad Dermatol 2005 May; 52 (5 Suppl. 1): S81–5PubMed

106.

Kwong WT, Hsu S. Pseudoporphyria associated with voriconazole. J Drugs Dermatol 2007 Oct; 6(10): 1042–4PubMed

107.

Frisch S, Askari SK, Beaty SR, et al. X-linked chronic granulomatous disease with voriconazole-induced photosensitivity/ photoaging reaction. J Drugs Dermatol 2010 May; 9(5): 562–4PubMed

108.

Frick MA, Soler-Palacin P, Nalda AM, et al. Photosensitivity in immunocompromised patients receiving long-term therapy with oral voriconazole. Pediatr Infect Dis J 2010 May; 29(5): 480–1PubMed

109.

Patel AR, Turner ML, Baird K, et al. Voriconazoleinduced phototoxicity masquerading as chronic graftversus-host disease of the skin in allogeneic hematopoietic cell transplant recipients. Biol Blood Marrow Transplant 2009 Mar; 15(3): 370–6PubMed

110.

Miller DD, Cowen EW, Nguyen JC, et al. Melanoma associated with long-term voriconazole therapy: a new manifestation of chronic photosensitivity. Arch Dermatol 2010 Mar; 146(3): 300–4PubMed

111.

McCarthy KL, Playford EG, Looke DF, et al. Severe photosensitivity causing multifocal squamous cell carcinomas secondary to prolonged voriconazole therapy. Clin Infect Dis 2007 Mar 1; 44(5): e55–6PubMed

112.

Cowen EW, Nguyen JC, Miller DD, et al. Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole. J Am Acad Dermatol 2010 Jan; 62(1): 31–7PubMed

113.

Stern RS, Nichols KT, Vakeva LH. Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA Follow-Up Study. N Engl J Med 1997 Apr 10; 336(15): 1041–5PubMed

114.

Stern RS, Lunder EJ. Risk of squamous cell carcinoma and methoxsalen (psoralen) and UV-A radiation (PUVA): a meta-analysis. Arch Dermatol 1998 Dec; 134(12): 1582–5PubMed

115.

Mohamed KN. Severe photodermatitis during ketoconazole therapy [letter]. Clin Exp Dermatol 1988 Jan; 13(1): 54PubMed

116.

Vassileva SG, Mateev G, Parish LC. Antimicrobial photosensitive reactions. Arch Intern Med 1998 Oct; 158(18): 1993–2000PubMed

117.

Dawson TA. Quinine lichenoid photosensitivity. Clin Exp Dermatol 1986 Nov; 11(6): 670–1PubMed

118.

Guzzo C, Kaidbey K. Persistent light reactivity from systemic quinine. Photodermatol Photoimmunol Photomed 1990 Aug; 7(4): 166–8PubMed

119.

Ljunggren B, Sjovall P. Systemic quinine photosensitivity. Arch Dermatol 1986 Aug; 122(8): 909–11PubMed

120.

Meyrick Thomas RH, Munro DD. Lichen planus in a photosensitive distribution due to quinine. Clin Exp Dermatol 1986 Jan; 11(1): 97–101PubMed

121.

Tan SV, Berth-Jones J, Burns DA. Lichen planus and photo-onycholysis induced by quinine [letter]. Clin Exp Dermatol 1989 Jul; 14(4): 335PubMed

122.

Singh G, Fries JF, Williams CA, et al. Toxicity profiles of disease modifying antirheumatic drugs in rheumatoid arthritis. J Rheumatol 1991 Feb; 18(2): 188–94PubMed

123.

Newell A, Avila C, Rodgers ME. Photosensitivity reaction of efavirenz [letter]. Sex Transm Infect 2000 Jun; 76(3): 221PubMed

124.

Pappert A, Grossman M, DeLeo V. Photosensitivity as the presenting illness in four patients with human immunodeficiency viral infection. Arch Dermatol 1994 May; 130(5): 618–23PubMed

125.

Stern RS, Bigby M. An expanded profile of cutaneous reactions to nonsteroidal anti-inflammatory drugs: reports to a specialty-based system for spontaneous reporting of adverse reactions to drugs. JAMA 1984 Sep 21; 252(11): 1433–7PubMed

126.

Levy ML, Barron KS, Eichenfield A, et al. Naproxeninduced pseudoporphyria: a distinctive photodermatitis. J Pediatr 1990 Oct; 117(4): 660–4PubMed

127.

Chishiki M, Kawada A, Fujioka A, et al. Photosensitivity due to ampiroxicam. Dermatology 1997; 195(4): 409–10PubMed

128.

Ingrish G, Rietschel RL. Oxaprozin-induced pseudoporphyria. Arch Dermatol 1996 Dec; 132(12): 1519–20PubMed

129.

Cron RQ, Finkel TH. Nabumetone induced pseudoporphyria in childhood. J Rheumatol 2000 Jul; 27(7): 1817–8PubMed

130.

Krischer J, Scolari F, Kondo-Oestreicher M, et al. Pseudoporphyria induced by nabumetone. J Am Acad Dermatol 1999 Mar; 40(3): 492–3PubMed

131.

Cummins R, Wagner-Weiner L, Paller A. Pseudoporphyria induced by celecoxib in a patient with juvenile rheumatoid arthritis. J Rheumatol 2000 Dec; 27(12): 2938–40PubMed

132.

Yazici AC, Baz K, Ikizoglu G, et al. Celecoxib-induced photoallergic drug eruption. Int J Dermatol 2004 Jun; 43(6): 459–61PubMed

133.

Al-Khenaizan S, Schechter JF, Sasseville D. Pseudoporphyria induced by propionic acid derivatives. J Cutan Med Surg 1999 Jan; 3(3): 162–6PubMed

134.

Johnston GA. Thiazide-induced lichenoid photosensitivity. Clin Exp Dermatol 2002 Nov; 27(8): 670–2PubMed

135.

Robinson HN, Morison WL, Hood AF. Thiazide diuretic therapy and chronic photosensitivity. Arch Dermatol 1985 Apr; 121(4): 522–4PubMed

136.

Burry JN, Lawrence JR. Phototoxic blisters from high frusemide dosage. Br J Dermatol 1976 May; 94(5): 495–9PubMed

137.

Rutherford T, Sinclair R. Photo-onycholysis due to indapamide. Australas J Dermatol 2007 Feb; 48(1): 35–6PubMed

138.

Kanwar AJ, Dhar S, Ghosh S. Photosensitive lichenoid eruption due to enalapril [letter]. Dermatology 1993; 187(1): 80PubMed

139.

Frye CB, Pettigrew TJ. Angioedema and photosensitive rash induced by valsartan. Pharmacotherapy 1998 Jul–Aug; 18(4): 866–8PubMed

140.

Grabczynska SA, Cowley N. Amlodipine inducedphotosensitivity presenting as telangiectasia. Br J Dermatol 2000 Jun; 142(6): 1255–6PubMed

141.

Basarab T, Yu R, Jones RR. Calcium antagonist-induced photo-exposed telangiectasia. Br J Dermatol 1997 Jun; 136(6): 974–5PubMed

142.

Boyer M, Katta R, Markus R. Diltiazem-induced photodistributed hyperpigmentation. Dermatol Online J 2003 Dec; 9(5): 10PubMed

143.

Harris L, McKenna WJ, Rowland E, et al. Side effects of long-term amiodarone therapy. Circulation 1983 Jan; 67(1): 45–51PubMed

144.

Chalmers RJ, Muston HL, Srinivas V, et al. High incidence of amiodarone-induced photosensitivity in North-West England [short report]. Br Med J (Clin Res Ed) 1982 Jul 31; 285(6338): 341

145.

Rappersberger K, Honigsmann H, Ortel B, et al. Photosensitivity and hyperpigmentation in amiodarone-treated patients: incidence, time course, and recovery. J Invest Dermatol 1989 Aug; 93(2): 201–9PubMed

146.

Bongard V, Marc D, Philippe V, et al. Incidence rate of adverse drug reactions during long-term follow-up of patients newly treated with amiodarone. Am J Ther 2006 Jul–Aug; 13(4): 315–9PubMed

147.

Yones SS, O’Donoghue NB, Palmer RA, et al. Persistent severe amiodarone-induced photosensitivity. Clin Exp Dermatol 2005 Sep; 30(5): 500–2PubMed

148.

Trimble JW, Mendelson DS, Fetter BF, et al. Cutaneous pigmentation secondary to amiodarone therapy. Arch Dermatol 1983 Nov; 1149(11): 914–8

149.

Wolf R, Dorfman B, Krakowski A. Quinidine-induced lichenoid and eczematous photodermatitis. Dermatologica 1987; 174(6): 285–9PubMed

150.

Bruce S, Wolf Jr JE. Quinidine-induced photosensitive livedo reticularis-like eruption. J Am Acad Dermatol 1985 Feb; 12 (2 Pt 1): 332–6PubMed

151.

Satanove A, McIntosh JS. Phototoxic reactions induced by high doses of chlorpromazine and thioridazine. JAMA 1967 Apr 17; 200(3): 209–12PubMed

152.

Epstein JH, Brunsting LA, Petersen MC, et al. A study of photosensitivity occurring with chlorpromazine therapy. J Invest Dermatol 1957 May; 28(5): 329–38PubMed

153.

Gielen K, Goossens A. Occupational allergic contact dermatitis from drugs in healthcare workers. Contact Dermatitis 2001 Nov; 45(5): 273–9PubMed

154.

Lovell CR, Cronin E, Rhodes EL. Photocontact urticaria from chlorpromazine. Contact Dermatitis 1986 May; 14(5): 290–1PubMed

155.

Gregoriou S, Karagiorga T, Stratigos A, et al. Photoonycholysis caused by olanzapine and aripiprazole. J Clin Psychopharmacol 2008 Apr; 28(2): 219–20PubMed

156.

Howanitz E, Pardo M, Losonczy M. Photosensitivity to clozapine [letter]. J Clin Psychiatry 1995 Dec; 56(12): 589PubMed

157.

Sicari MC, Lebwohl M, Baral J, et al. Photoinduced dermal pigmentation in patients taking tricyclic antidepressants: histology, electron microscopy, and energy dispersive spectroscopy. J Am Acad Dermatol 1999 Feb; 40 (2 Pt 2): 290–3PubMed

158.

Walter-Ryan WG, Kern III EE, Shirriff JR, et al. Persistent photoaggravated cutaneous eruption induced by imipramine. JAMA 1985 Jul 19; 254(3): 357–8PubMed

159.

Ram-Wolf C, Mahe E, Saiag P. Escitalopram photoinduced erythroderma. J Eur Acad Dermatol Venereol 2008 Aug; 22(8): 1015–7PubMed

160.

Gaufberg E, Ellison JM. Photosensitivity reaction to fluoxetine [letter]. J Clin Psychiatry 1995 Oct; 56(10): 486PubMed

161.

Lin NC, Chou JY, Chen H, et al. Sertraline-induced photoallergic reaction. J Clin Psychopharmacol 2009 Feb; 29(1): 95–6PubMed

162.

Inaloz HS, Kirtak N, Herken H, et al. Citalopram-induced photopigmentation. J Dermatol 2001 Dec; 28(12): 742–5PubMed

163.

Case JD, Yusk JW, Callen JP. Photosensitive reaction to phenelzine: a case report. Photodermatol 1988 Apr; 5(2): 101–2PubMed

164.

Kanwar AJ, Gupta R, Das Mehta S, et al. Photosensitivity due to alprazolam [letter]. Dermatologica 1990; 181(1): 75PubMed

165.

Holme SA, Pearse AD, Anstey AV. Chronic actinic dermatitis secondary to simvastatin. Photodermatol Photoimmunol Photomed 2002 Dec; 18(6): 313–4PubMed

166.

Gardeazabal J, Gonzalez M, Izu R, et al. Phenofibrateinduced lichenoid photodermatitis. Photodermatol Photoimmunol Photomed 1993 Aug; 9(4): 156–8PubMed

167.

Leenutaphong V, Manuskiatti W. Fenofibrate-induced photosensitivity. J Am Acad Dermatol 1996 Nov; 35 (5 Pt 1): 775–7PubMed

168.

Chang CH, Chang JW, Hui CY, et al. Severe photosensitivity reaction to vandetanib. J Clin Oncol 2009 Sep 20; 27(27): e114–5PubMed

169.

Rousselot P, Larghero J, Raffoux E, et al. Photosensitization in chronic myelogenous leukaemia patients treated with imatinib mesylate. Br J Haematol 2003 Mar; 120(6): 1091–2PubMed

170.

Falkson G, Schulz EJ. Skin changes in patients treated with 5-fluorouracil. Br J Dermatol 1962 Jun; 74: 229–36PubMed

171.

Hague JS, Ilchyshyn A. Lichenoid photosensitive eruption due to capecitabine chemotherapy for metastatic breast cancer. Clin Exp Dermatol 2007 Jan; 32(1): 102–3PubMed

172.

Willey A, Glusac EJ, Bolognia JL. Photoeruption in a patient treated with capecitabine (Xeloda) for metastatic breast cancer [letter]. J Am Acad Dermatol 2002 Sep; 47(3): 453PubMed

173.

Tsoussis S, Vourliotaki I, Ekonomidou F, et al. Capecitabine as an alternative in a case of fluorouracil-induced photodermatitis. Clin Oncol (R Coll Radiol) 2006 Mar; 18(2): 158–9

174.

Cohen PR. Photodistributed erythema multiforme: paclitaxel-related, photosensitive conditions in patients with cancer. J Drugs Dermatol 2009 Jan; 8(1): 61–4PubMed

175.

Hussain S, Anderson DN, Salvatti ME, et al. Onycholysis as a complication of systemic chemotherapy: report of five cases associated with prolonged weekly paclitaxel therapy and review of the literature. Cancer 2000 May 15; 88(10): 2367–71PubMed

176.

Leon-Mateos A, Zulaica A, Caeiro JL, et al. Photo-induced granulomatous eruption by hydroxyurea. J Eur Acad Dermatol Venereol 2007 Nov; 21(10): 1428–9PubMed

177.

Buesa JM, Gracia M, Valle M, et al. Phase I trial of intermittent high-dose dacarbazine. Cancer Treat Rep 1984 Mar; 68(3): 499–504PubMed

178.

Serrano G, Aliaga A, Febrer I, et al. Dacarbazine-induced photosensitivity. Photodermatol 1989 Jun; 6(3): 140–1PubMed

179.

Leroy D, Dompmartin A, Szczurko C. Flutamide photosensitivity. Photodermatol Photoimmunol Photomed 1996 Oct; 12(5): 216–8PubMed

180.

Shah N, Zambidis ET. False-photosensitivity and transient hemiparesis following high-dose intravenous and intrathecal methotrexate for treatment of acute lymphoblastic leukemia. Pediatr Blood Cancer 2009 Jul; 53(1): 103–5PubMed

181.

Kharfan Dabaja MA, Morgensztern D, Markoe AM, et al. Radiation recall dermatitis induced by methotrexate in a patient with Hodgkin’s disease. Am J Clin Oncol 2000 Oct; 23(5): 531–3PubMed

182.

Hird AE, Wilson J, Symons S, et al. Radiation recall dermatitis: case report and review of the literature. Curr Oncol 2008 Jan; 15(1): 53–62PubMed

183.

Wong RC, Gilbert M, Woo TY, et al. Photosensitivity and isotretinoin therapy. J Am Acad Dermatol 1986 Jun; 14(6): 1095–6PubMed

184.

Balagula Y, Newman SB, Lacouture ME. Photodermatosis associated with eculizumab (Soliris): a novel monoclonal antibody directed against the complement protein C 5. Am J Hematol 2010 May; 85(5): 392–3PubMed

185.

Rivarola de Gutierrez E, Abaca H. Photodistributed lichenoid drug eruption with rhabdomyolysis occurring during leflunomide therapy. Dermatology 2004; 208(3): 232–3PubMed

186.

Horiuchi Y, Shimakura S. Mesalazine and photosensitivity. Am J Gastroenterol 1999 Nov; 94(11): 3386–7PubMed

187.

Lowe NJ, Fakouhi TD, Stern RS, et al. Photoreactions with a fluoroquinolone antimicrobial: evening versus morning dosing. Clin Pharmacol Ther 1994 Nov; 56(5): 587–91PubMed

188.

Collins P, Ferguson J. Narrow-band UVB (TL-01) phototherapy: an effective preventative treatment for the photodermatoses. Br J Dermatol 1995 Jun; 132(6): 956–63PubMed

Titel: Drug-Induced Photosensitivity
Culprit Drugs, Management and Prevention
verfasst von: Aaron M. Drucker
Dr Cheryl F. Rosen
Publikationsdatum: 01.10.2011
Verlag: Springer International Publishing
Erschienen in: Drug Safety / Ausgabe 10/2011
Print ISSN: 0114-5916
Elektronische ISSN: 1179-1942
DOI: https://doi.org/10.2165/11592780-000000000-00000

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 10/2011

Off-Label Pharmacovigilance

Drug-Induced Taste and Smell Alterations

International Society of Pharmacovigilance Abstracts 11th ISoP Annual Meeting ‘Next Stop: Istanbul — Bridging the Continents!’ Istanbul, Turkey 26–28 October 2011

Fluoroquinolone-Associated Myasthenia Gravis Exacerbation

Communication in Drug Safety

Is the Large Simple Trial Design Used for Comparative, Post-Approval Safety Research?