Abstract
The CB1 receptor is expressed in the central nervous system and numerous other tissues including heart, lung and uterus and has been recognized as an important therapeutic target for pain, appetite modulation, glaucoma, multiple sclerosis and other indications. An interesting feature of this GPCR is its ability to be activated by a number of structurally different classes of compounds, thus, raising the possibility of multiple activated forms of the receptor. Understanding of the structure-activity relationships of cannabinergic ligands has paved the road for the development of novel ligands exhibiting receptor subtype selectivity and efficacy. This review highlights the important CB1 cannabinergic ligands developed to date.
Keywords: cannabinoid receptors, cb agonists, cb antagonists, cb selectivity
Mini-Reviews in Medicinal Chemistry
Title: CB1 Cannabinoid Receptor Ligands
Volume: 5 Issue: 7
Author(s): Ganesh A. Thakur, Spyros P. Nikas and Alexandros Makriyannis
Affiliation:
Keywords: cannabinoid receptors, cb agonists, cb antagonists, cb selectivity
Abstract: The CB1 receptor is expressed in the central nervous system and numerous other tissues including heart, lung and uterus and has been recognized as an important therapeutic target for pain, appetite modulation, glaucoma, multiple sclerosis and other indications. An interesting feature of this GPCR is its ability to be activated by a number of structurally different classes of compounds, thus, raising the possibility of multiple activated forms of the receptor. Understanding of the structure-activity relationships of cannabinergic ligands has paved the road for the development of novel ligands exhibiting receptor subtype selectivity and efficacy. This review highlights the important CB1 cannabinergic ligands developed to date.
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Cite this article as:
Thakur A. Ganesh, Nikas P. Spyros and Makriyannis Alexandros, CB1 Cannabinoid Receptor Ligands, Mini-Reviews in Medicinal Chemistry 2005; 5 (7) . https://dx.doi.org/10.2174/1389557054368772
DOI https://dx.doi.org/10.2174/1389557054368772 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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