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Dermal argyria: Cutaneous manifestation of a megaprosthesis for distal femoral osteosarcoma

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Abstract

We present a patient with dermal argyria as a cutaneous manifestation of a silver-coated megaprosthesis used for a distal femoral osteosarcoma. Histological and electron microscopic analyses also showed silver deposition in the dermis.

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References

  1. Hillmann A, Hoffmann C, Gosheger G, Krakau H, Winkelmann W. Malignant tumor of the distal part of the femur or the proximal part of the tibia: Endoprosthetic replacement or rotationplasty. Functional outcome and quality-of-life measurements. Malignant tumor of the distal part of the femur or the proximal part of the tibia: Endoprosthetic replacement or rotationplasty 1999;81:462–8.

    CAS  PubMed  Google Scholar 

  2. Grimer RJ, Belthur M, Chandrasekar C, Carter SR, Tillman RM. Two-stage revision for infected endoprostheses used in tumor surgery. Clin Orthop Relat Res 2002;395:193–203.

    Article  Google Scholar 

  3. Hussmann B, Johann I, Kauther MD, Landgraeber S, Jäger M, Lendemans S. Measurement of the silver ion concentration in wound fluids after implantation of silver-coated megaprostheses: Correlation with the clinical outcome. Biomed Res Int 2013;2013:763096.

    Article  CAS  Google Scholar 

  4. Bechert T, Steinrücke P, Guggenbichler JP. A new method for screening antiinfective biomaterials. Nat Med 2000;6:1053–6.

    Article  CAS  Google Scholar 

  5. Zimmerli W, Lew PD, Waldvogel FA. Pathogenesis of foreign body infection. Evidence for a local granulocyte defect. Pathogenesis of foreign body infection 1984;73:1191–200.

    CAS  Google Scholar 

  6. Tobin EJ, Bambauer R. Silver coating of dialysis catheters to reduce bacterial colonization and infection. Ther Apher Dial 2003;7:504–9.

    Article  Google Scholar 

  7. Hardes J, Ahrens H, Gebert C, Streitbuerger A, Buerger H, Erren M, et al. Lack of toxicological side-effects in silver-coated megaprostheses in humans. Biomaterials 2007;28:2869–75.

    Article  CAS  Google Scholar 

  8. Gosheger G, Hardes J, Ahrens H, Streitburger A, Buerger H, Erren M, et al. Silver-coated megaendoprostheses in a rabbit model: An analysis of the infection rate and toxicological side effects. Biomaterials 2004;25:5547–56.

    Article  CAS  Google Scholar 

  9. Hardes J, von Eiff C, Streitbuerger A, Balke M, Budny T, Henrichs MP, et al. Reduction of periprosthetic infection with silver-coated megaprostheses in patients with bone sarcoma. J Surg Oncol 2010;101:389–95.

    PubMed  Google Scholar 

  10. Darouiche RO. Antiinfective efficacy of silver-coated medical prostheses. Clin Infect Dis 1999;29:1371–7; quiz 1378.

    Article  CAS  Google Scholar 

  11. Collinge CA, Goll G, Seligson D, Easley KJ. Pin tract infections: Silver vs uncoated pins. Orthopedics 1994;17:445–8.

    CAS  PubMed  Google Scholar 

  12. Coester LM, Nepola JV, Allen J, Marsh JL. The effects of silver coated external fixation pins. Iowa Orthop J 2006;26:48–53.

    PubMed  PubMed Central  Google Scholar 

  13. Massè A, Bruno A, Bosetti M, Biasibetti A, Cannas M, Gallinaro P. Prevention of pin track infection in external fixation with silver coated pins: Clinical and microbiological results. J Biomed Mater Res 2000;53:600–4.

    Article  Google Scholar 

  14. Bosetti M, Massè A, Tobin E, Cannas M. Silver coated materials for external fixation devices: In vitro biocompatibility and genotoxicity. Biomaterials 2002;23:887–92.

    Article  CAS  Google Scholar 

  15. Lansdown AB. A pharmacological and toxicological profile of silver as an antimicrobial agent in medical devices. Adv Pharmacol Sci 2010;2010:910686.

    PubMed  PubMed Central  Google Scholar 

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Correspondence to Ahmet Karakasli.

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Karakasli, A., Hapa, O., Akdeniz, O. et al. Dermal argyria: Cutaneous manifestation of a megaprosthesis for distal femoral osteosarcoma. IJOO 48, 326–328 (2014). https://doi.org/10.4103/0019-5413.132528

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  • DOI: https://doi.org/10.4103/0019-5413.132528

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