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01.06.2012 | Clinical and Epidemiological Study

Long-term immunogenicity of hepatitis B vaccination in children and adolescents in a southern Italian town

verfasst von: T. Stroffolini, V. Guadagnino, B. Caroleo, G. De Sarro, A. Focà, M. C. Liberto, A. Giancotti, G. S. Barreca, N. Marascio, F. L. Lombardo, O. Staltari, “Sersale’s Study” Group

Erschienen in: Infection | Ausgabe 3/2012

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Abstract

Purpose

Universal anti-hepatitis B vaccination of infants and of 12-year-old children became mandatory in Italy in 1991. The purpose of this study was to evaluate the persistence of anti-hepatitis B surface (HBs) antibodies several years after a primary course of vaccination.

Methods

In 2010, anti-HBs titers were measured in all subjects aged between 5 and 25 years residing in a southern Italian town. Individuals with an anti-hepatitis B antibody concentration of 10 IU/ml or more were considered to be protected.

Results

Of the 671 subjects evaluated, 149 (30%) lacked protective antibodies. Fifty-three (29.4%) of the subjects had been vaccinated ≤10 years earlier and 96 (30.3%) more than 10 years earlier (P = not significant). Subjects vaccinated in infancy were more likely to lack protective anti-HBs antibodies than subjects vaccinated at 12 years of age, regardless of the years elapsed since immunization.

Conclusions

Most subjects maintained protective antibodies for a considerable number of years after vaccination. Vaccination in adolescence results in more prolonged immunogenicity than vaccination in infancy.

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Titel: Long-term immunogenicity of hepatitis B vaccination in children and adolescents in a southern Italian town
verfasst von: T. Stroffolini
V. Guadagnino
B. Caroleo
G. De Sarro
A. Focà
M. C. Liberto
A. Giancotti
G. S. Barreca
N. Marascio
F. L. Lombardo
O. Staltari
“Sersale’s Study” Group
Publikationsdatum: 01.06.2012
Verlag: Springer-Verlag
Erschienen in: Infection / Ausgabe 3/2012
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI: https://doi.org/10.1007/s15010-011-0233-2

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Long-term immunogenicity of hepatitis B vaccination in children and adolescents in a southern Italian town