Introduction
Pro-angiogenic factors | FGF-2 VEGF IL-6 IL-8 PDGF G-CSF GM-CSF |
Angiostatic factors | TSP-1 IL-12 IL-18 CXCL-9 CXCL-10 |
Pro-inflammatory molecules | IL-1 IL-6 IL-12 IL-23 TNFα Nitric oxide CXCL-9 CXCL-10 CXCL-11 |
Anti-inflammatory molecules | IL-10 TGFβ CCL-17 CCL-18 CCL-22 Class A scavenger receptor (CD204) Mannose receptor C type 1 (CD206) Hemoglobin scavenger receptor (CD163) |
Human lymphomas
Macrophages and angiogenesis in non-Hodgkin lymphomas (Table 2)
Macrophages and angiogenesis in Hodgkin lymphomas (Table 2)
Non-Hodgkin lymphoma | |
Diffuse large B cell lymphoma (DLBCL) | |
Follicular lymphoma | M2 TAMs number correlates with angiogenesis [42] |
Mantle cell lymphoma | M1 and M2 TAMs positively correlate with ki67 and negatively with overall survival (OS) [50] M2 TAMs adversely affect outcome [73] |
Classic Hodgkin lymphoma | TAMs involved in the mechanism of action of checkpoint inhibitors [35] TAM-derived PDL-1 and HRS cell-derived PD-L1 and PD-L2 neutralize the activity of PD-1+ T cells and NK cells [55] Higher number of CD68+ TAMs is associated with shortened survival and the outcome of autologous stem-cell transplantation [64] M1 TAMs number correlates with favorable prognosis in the mixed cellularity cHL [69] Lack of TAMs is beneficial for HL growth [76] High number of CD163+ TAMs correlates with VEGF-A levels and increased microvascular density [77] |
Personal experience (Table 3)
Diffuse large B cell lymphoma (DLBCL) | Higher number of CD68+ TAMs and microvessels in the non-responder versus the responder groups [78] A higher number of CD68+ TAMs in the chemo-resistant group versus the chemo-sensitive one [68] Increase in CD68+, CD163+, and CD34+ cells in the ABC subgroup versus GCB one [71] |
Mantle cell lymphoma | Reduced CD68+ and CD163+ TAMs in the group with > 40% of Sox11+ cells versus negative and 1–39% of positivity groups [72] |
Splenic marginal zone lymphoma | Increased number of CD68+ and CD163+ TAMs in the MALT compared to the healthy ones [75] |
MALT lymphoma | Significant increase in CD68+ and CD163+ TAMs and microvascular density [76] |
Follicular lymphoma | Significant increase in CD68+ and CD163+ TAMs in FL grades versus healthy controls [77] |
Classic Hodgkin lymphoma | Significant increase in CD68+ and CD163+ TAMs and CD34+ microvessels in REL patients versus to RESP to ABVC therapy [78] |