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01.04.2015 | Review article

Mechanisms mediating renal sympathetic nerve activation in obesity-related hypertension

verfasst von: W. Chen, S. Leo, C. Weng, X. Yang, Y. Wu, X. Tang, MD, PhD

Erschienen in: Herz | Sonderheft 2/2015

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Abstract

Excessive renal sympathetic nerve activation may be one of the mechanisms underlying obesity-related hypertension. Impaired baroreflex sensitivity, adipokine disorders—such as leptin, adiponectin, and resistin—activation of the renin-angiotensin system, hyperinsulinemia, insulin resistance, and renal sodium retention present in obesity increase renal sympathetic nerve activity, thus contributing to the development of hypertension. Renal sympathetic denervation reduces both renal sympathetic activity and blood pressure in patients with obesity-related hypertension.

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Titel: Mechanisms mediating renal sympathetic nerve activation in obesity-related hypertension
verfasst von: W. Chen
S. Leo
C. Weng
X. Yang
Y. Wu
X. Tang, MD, PhD
Publikationsdatum: 01.04.2015
Verlag: Urban & Vogel
Erschienen in: Herz / Ausgabe Sonderheft 2/2015
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI: https://doi.org/10.1007/s00059-014-4072-7

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