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24.03.2023 | ORIGINAL ARTICLE

Microvascular damage evaluation based on nailfold videocapillarosopy in sarcoidosis

verfasst von: Şerife Şeyda Zengin Acemoğlu, İpek Türk, Mehmet Ali Aşık, Ayşegül Özdoğan Bircan, Pelin Pınar Deniz, Didem Arslan, İsmail Hanta, İlker Ünal

Erschienen in: Clinical Rheumatology | Ausgabe 7/2023

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Abstract

Objectives

Microvascular damage is thought to play a role in the pathogenesis of sarcoidosis. We aimed to evaluate the nailfold capillaroscopy (NVC) pattern to detect microvascular changes in patients with sarcoidosis and the relationship of capillaroscopic parameters with clinical variables and disease-related measurements.

Patients and methods

Forty-two patients with sarcoidosis and 42 age- and sex-matched patients with systemic sclerosis (SSc) and healthy individuals were included in this cross-sectional case–control study. Patients aged 18–80 years who met the current American Thoracic Society criteria for sarcoidosis were included. NVC was performed by a digital microscope under a magnification of × 200. Capillary density, number of dilated, giant and neoangiogenic capillaries, capillary loop diameter, capillary shape, micro-hemorrhages, and number of avascular areas, were evaluated by an assessor who was blind to the groups allocation.

Results

Among the capillaroscopic parameters, neoangiogenesis and dilated capillaries, which can be seen in the pattern of scleroderma, were detected in patients with sarcoidosis but not significantly different from the control group (p = 0.055; p = 0.433, respectively). The rate of tortuosity and crossing capillaries of 50% and above was significantly higher in the sarcoidosis group than in SSc and healthy controls (p < 0.05). In patients with sarcoidosis, the only statistically significant finding was; forced expiratory volume (FEV1) in one second was lower in patients with a crossed capillary rate > 50% than in patients with a crossed capillary rate of less than 50% (FEV1; 87.21 ± 19.3, 102.5 ± 14.8, p = 0.04; respectively).

Conclusion

Patients with a diagnosis of sarcoidosis have different capillaroscopic patterns. The presence of these nonspecific abnormal patterns may reflect microvascular damage in the pathophysiology of sarcoidosis.

Key Points

• Microvascular damage may play a role in the pathogenesis of sarcoidosis.

• There may be some nonspecific abnormal findings in capillaroscopy findings in sarcoidosis.

• Capillaroscopy may be valuable in reflecting sarcoidosis lung injury.

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Titel: Microvascular damage evaluation based on nailfold videocapillarosopy in sarcoidosis
verfasst von: Şerife Şeyda Zengin Acemoğlu
İpek Türk
Mehmet Ali Aşık
Ayşegül Özdoğan Bircan
Pelin Pınar Deniz
Didem Arslan
İsmail Hanta
İlker Ünal
Publikationsdatum: 24.03.2023
Verlag: Springer International Publishing
Erschienen in: Clinical Rheumatology / Ausgabe 7/2023
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-023-06582-z

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Microvascular damage evaluation based on nailfold videocapillarosopy in sarcoidosis