Background
Method
Patients
Data collection
Data analysis
Results
Frequency of prescriptions of drug classes in combination therapy
1994 - 1997 | 1998 - 2001 | 2002 - 2005 | 2006 - 2009 | Overall | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
N | % | N | % | N | % | N | % | N | % | ||
Number of patients | 248 | 454 | 711 | 832 | 2246 | ||||||
Number of patients monotherapy | 53 |
21.4
| 99 |
21.8
| 85 |
12.0
| 97 |
11.7
| 334 |
14.9
| |
Number of patients combination therapy | 195 |
78.6
| 355 |
78.2
| 626 |
88.0
| 735 |
88.3
| 1912 |
85.1
| |
Antidepressants | monotherapy | 33 |
13.3
| 54 |
11.9
| 41 |
5.8
| 43 |
5.2
| 171 |
7.6
|
combination therapy | 172 |
69.4
| 317 |
69.8
| 531 |
74.7
| 634 |
76.2
| 1655 |
73.7
| |
Antipsychotics | monotherapy | 8 |
3.2
| 16 |
3.5
| 16 |
2.3
| 30 |
3.6
| 70 |
3.1
|
combination therapy | 97 |
39.1
| 194 |
42.7
| 418 |
58.8
| 534 |
64.2
| 1244 |
55.4
| |
Anticonvulsants | monotherapy | 6 |
2.4
| 16 |
3.5
| 15 |
2.1
| 14 |
1.7
| 51 |
2.3
|
combination therapy | 65 |
26.2
| 177 |
39.0
| 402 |
56.5
| 425 |
51.1
| 1069 |
47.6
| |
Lithium | monotherapy | 6 |
2.4
| 13 |
2.9
| 13 |
1.8
| 10 |
1.2
| 42 |
1.9
|
combination therapy | 105 |
42.3
| 152 |
33.5
| 204 |
28.7
| 275 |
33.1
| 736 |
32.8
|
Psychotropic substances in mono- and combination therapy
% | 1994 - 1997 | 1998 – 2001 | 2002 – 2005 | 2006 - 2009 | Overall |
---|---|---|---|---|---|
N | 248 | 454 | 711 | 832 | 2246 |
Lithium | 2.4 + 42.3
| 2.9 + 33.5
| 1.8 + 28.7
| 1.2 + 33.1
| 1.9 + 32.8
|
SSRI overall | 2.4 + 15.3
| 3.5 + 22.4
| 2.4 + 29
| 2.0 + 28.6
| 2.5 + 26.0
|
Valproic acid | 0.4 + 4.8
| 1.8 + 19.8
| 1.5 + 28.4
| 1.3 + 24.4
| 1.4 + 22.8
|
Mirtazapine |
3.2
| 2.6 + 12.1
| 2.1 + 20.7
| 2.0 + 18.8
| 2.0 + 16.3
|
Venlafaxine | 2.0 + 4.4
| 1.1 + 10.4
| 1.3 + 21.5
| 1.1 + 18.3
| 1.2 + 16.2
|
Quetiapine |
0.7
| 0.3 + 12.7
| 1.4 + 28.1
| 0.6 + 14.6
| |
Lamotrigine | 0.7 + 2.9
| 0.1 + 17.7
| 0.4 + 22.2
| 0.3 + 14.4
| |
Olanzapine |
0.4
| 0.9 + 9.5
| 0.7 + 18
| 1.1 + 13.6
| 0.8 + 12.7
|
Carbamazepine | 2.0 + 21
| 1.8 + 18.7
| 0.4 + 10.4
| 0.2 + 5.5
| 0.8 + 11.4
|
Escitalopram | 0.7 + 10.1
| 1.1 + 14.4
| 0.6 + 8.5
| ||
Citalopram | 0.8 + 4.8
| 1.3 + 8.1
| 0.8 + 9.8
| 0.2 + 7
| 0.7 + 7.9
|
Risperidone |
1.6
| 0.2 + 5.9
| 0.1 + 7.3
| 0.2 + 7.6
| 0.2 + 6.5
|
Sertraline |
0.4
| 0.9 + 6.4
| 0.4 + 5.1
| 0.5 + 4.0
| 0.5 + 4.4
|
Paroxetine | 0.8 + 8.5
| 1.3 + 5.3
| 0.1 + 2.5
|
2.4
| 0.4 + 3.7
|
Perazine | 0.8 + 5.6
| 0.4 + 5.3
|
3.1
|
1.3
| 0.2 + 3.2
|
Reboxetine | 1.1 + 2.9
| 0.1 + 4.2
| 0.2 + 3.0
| 0.4 + 3.0
| |
Haloperidol | 0.8 + 11.3
| 0.4 + 4.0
|
1.5
| 0.7 + 1.3
| 0.4 + 3.0
|
Duloxetine | 0.1 + 1.5
| 0.1 + 6.6
| 0.1 + 2.9
| ||
Melperone |
2.0
| 0.2 + 3.3
| 0.4 + 3.7
|
2.4
| 0.2 + 2.9
|
Promethazine | 0.8 + 5.6
| 0.2 + 3.1
| 0.1 + 1.4
| 0.5 + 1.7
| 0.4 + 2.3
|
Aripiprazole |
1.5
| 0.1 + 4.7
|
2.0
| ||
Clozapine |
3.2
| 0.2 + 2.2
| 0.3 + 1.7
| 0.1 + 1.8
| 0.2 + 2.0
|
Fluoxetine | 0.8 + 1.6
|
2.6
| 0.4 + 1.5
| 0.2 + 0.8
| 0.3 + 1.5
|
Frequent combinations of psychotropic substances
a.
| |||
---|---|---|---|
Lithium | SSRI |
9.2%
| |
Valproic acid | SSRI |
7.2
| |
Lithium | Mirtazapine |
5.8
| |
Lithium | Venlafaxine |
5.7
| |
Quetiapine | SSRI |
5.2
| |
Quetiapine | Lithium |
5.1
| |
Lamotrigine | SSRI |
4.9
| |
Valproic acid | Venlafaxine |
4.6
| |
Valproic acid | Mirtazapine |
4.5
| |
Valproic acid | Lithium |
4.1
| |
Quetiapine | Lamotrigine |
3.9
| |
SSRI | Mirtazapine |
3.8
| |
Olanzapine | Lithium |
3.7
| |
Lamotrigine | Venlafaxine |
3.7
| |
Olanzapine | SSRI |
3.6
| |
Quetiapine | Valproic acid |
3.4
| |
Mirtazapine | Venlafaxine |
3.4
| |
Lamotrigine | Lithium |
3.3
| |
Valproic acid | Olanzapine |
3.2
| |
Lamotrigine | Mirtazapine |
3.2
| |
b.
| |||
SSRI | Quetiapine | Lithium |
1.7%
|
SSRI | Quetiapine | Lamotrigine |
1.3
|
SSRI | Mirtazapine | Lithium |
1.2
|
SSRI | Mirtazapine | Valproic acid |
1.2
|
SSRI | Mirtazapine | Venlafaxine |
1.2
|
Lithium | Mirtazapine | Venlafaxine |
1.2
|
SSRI | Olanzapine | Lithium |
1.1
|
Lithium | Quetiapine | Venlafaxine |
1.1
|
Lithium | Quetiapine | Lamotrigine |
1.1
|
Frequent combinations of classes of substances
Lithium | Antidepressants (SSRI, Mir, Ven) | atypical Neuroleptics (Quet, Ola, Ri) |
4%
|
Lithium | Antidepressants (SSRI, Mir, Ven) | Antidepressants (SSRI, Mir, Ven) |
3%
|
Lithium | atypical Neuroleptics (Quet, Ola, Ri) | Anticonvulsives (Val, Lam) |
1%
|
SSRI | atypical Neuroleptics (Quet, Ola, Ri) | Anticonvulsives (Val, Lam) |
3%
|
SSRI | Mirtazapine | Anticonvulsives (Val, Lam) |
2%
|
SSRI | Mirtazapine | Venlafaxine |
1%
|