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European Archives of Psychiatry and Clinical Neuroscience

Erschienen in:

01.06.2008 | ORIGINAL PAPER

Neuropsychological and hypothalamic–pituitary-axis function in female patients with melancholic and non-melancholic depression

verfasst von: Ioannis Michopoulos, MD, Iannis M. Zervas, MD, Chris Pantelis, MBBS, MD, MRCPsych, FRANZCP, Eleftheria Tsaltas, PhD, Vassiliki-Maria Papakosta, Fotini Boufidou, MD, Chrissoula Nikolaou, MD, Charalambos Papageorgiou, MD, Costas R. Soldatos, MD, Lefteris Lykouras, MD, PhD, FICPM

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 4/2008

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Abstract

Background

Executive function deficits in depression implicate involvement of frontal–striatal circuits. However, studies of hypothalamic–pituitary-axis (HPA) function suggest that stress-related brain changes of hippocampus may also implicate prefrontal–hippocampal circuits, which may explain the profile of both executive dysfunction and memory deficits. In this study we examined the performance of patients with major depressive disorder (MDD) on tasks of memory and executive function in relation to melancholic features and to cortisol levels. Our hypothesis was that raised cortisol levels in melancholic patients would correlate with these deficits.

Method

Forty female MDD patients, 20 having melancholic features (MEL vs. Non-MEL), and 20 sex- age- and education-matched normal controls were investigated using the Cambridge neuropsychological test automated battery (CANTAB), to assess memory (paired associative learning, PAL; short-term recognition memory, SRM) and executive (intradimensional/ extradimensional set-shifting, ID/ED; Stockings of Cambridge, SOC) functions. Plasma and salivary cortisol levels were measured.

Results

The MDD patients performed worse than controls on PAL and both executive tasks. The MEL group differed from controls on all tests, and differed from the non-MEL only at the ED stage of the ID/ED task. Patient cortisol levels were within the normal range and did not correlate with neuropsychological performance for any group.

Conclusions

MDD patients showed neuropsychological deficits on tasks of executive function and memory, supporting the model of frontal-temporal dysfunction. MEL vs. non-MEL performed worse overall and demonstrated a qualitative difference in set shifting, perhaps implicating more extensive prefrontal involvement. Cortisol levels did not correlate with depression severity or the observed deficits.

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Titel: Neuropsychological and hypothalamic–pituitary-axis function in female patients with melancholic and non-melancholic depression
verfasst von: Ioannis Michopoulos, MD
Iannis M. Zervas, MD
Chris Pantelis, MBBS, MD, MRCPsych, FRANZCP
Eleftheria Tsaltas, PhD
Vassiliki-Maria Papakosta
Fotini Boufidou, MD
Chrissoula Nikolaou, MD
Charalambos Papageorgiou, MD
Costas R. Soldatos, MD
Lefteris Lykouras, MD, PhD, FICPM
Publikationsdatum: 01.06.2008
Verlag: D. Steinkopff-Verlag
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 4/2008
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-007-0781-8

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Neuropsychological and hypothalamic–pituitary-axis function in female patients with melancholic and non-melancholic depression