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Erschienen in:
01.03.2015 | Maternal-Fetal Medicine
Oral versus vaginal misoprostol for induction of labor in Enugu, Nigeria: a randomized controlled trial
Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 3/2015
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Objective
The study aimed at comparing the effectiveness and maternal satisfaction of oral misoprostol with vaginal misoprostol for induction of labor at term.
Materials and methods
A randomized controlled trial of 140 term pregnant women at the University of Nigeria Teaching Hospital Enugu, Nigeria, was conducted from April 2011 to May 2012. The women were equally randomized into two groups (A and B) to receive oral and vaginal misoprostol, respectively.
Results
The vaginal route reduced the mean induction–vaginal delivery interval by four-and-half hours (20.7 ± 12.1 vs. 16.2 ± 10.4; mean difference: 4.50, 95 % CI 0.63–0.82; p = 0.02). Furthermore, the mean dose of misoprostol required to achieve induction of labor and the mean duration of oxytocin augmentation when indicated were significantly less in the vaginal group than in the oral group (2.5 ± 1.3 vs. 2.0 ± 1.1; mean difference: 0.50, 95 % CI 0.10–0.90; p = 0.02 and 4.6 ± 3.2 vs. 3.4 ± 3.1; mean difference: 1.20, 95 % CI 0.15–0.23; p = 0.03 respectively). However, neonatal complications and maternal satisfaction were similar between the two groups.
Conclusion
Both routes of administration are effective in the induction of labor at term and have comparable maternal satisfaction. However, the vaginal route has the added advantage of shorter induction–delivery interval among others, and thus should be highly considered when induction of labor is indicated at term.