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01.12.2024 | Original Article

Overlapping stimulation of subthalamic nucleus and dentato-rubro-thalamic tract in Parkinson’s disease after deep brain stimulation

verfasst von: K. Wiśniewski, A. Gajos, K. Zaczkowski, A. Szulia, M. Grzegorczyk, A. Dąbkowska, R. Wójcik, E. J. Bobeff, K. Kwiecień, M. G. Brandel, A. Fahlström, A. Bogucki, B. Ciszek, D. J. Jaskólski

Erschienen in: Acta Neurochirurgica | Ausgabe 1/2024

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Abstract

Background

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces tremor, rigidity, and akinesia. According to the literature, the dentato-rubro-thalamic tract (DRTt) is verified target for DBS in essential tremor; however, its role in the treatment of Parkinson’s disease is only vaguely described. The aim of our study was to identify the relationship between symptom alleviation in PD patients and the distance of the DBS electrode electric field (EF) to the DRTt.

Methods

A single-center retrospective analysis of patients (N = 30) with idiopathic Parkinson’s disease (PD) who underwent DBS between November 2018 and January 2020 was performed. DRTt and STN were visualized using diffusion-weighted imaging (DWI) and tractography protocol of magnetic resonance (MR). The EF was calculated and compared with STN and course of DRTt. Evaluation of patients before and after surgery was performed with use of UPDRS-III scale. The association between distance from EF to DRTt and clinical outcomes was examined. To confirm the anatomical variation between DRTt and STN observed in tractography, white matter dissection was performed with the Klingler technique on ten human brains.

Results

Patients with EF overlapping STN and DRTt benefited from significant motor symptoms improvement. Anatomical findings confirmed the presence of population differences in variability of the DRTt course and were consistent with the DRTt visualized by MR.

Conclusions

DRTt proximity to STN, the main target in PD DBS surgery, confirmed by DWI with tractography protocol of MR combined with proper predefined stimulation parameters may improve efficacy of DBS-STN.

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Titel: Overlapping stimulation of subthalamic nucleus and dentato-rubro-thalamic tract in Parkinson’s disease after deep brain stimulation
verfasst von: K. Wiśniewski
A. Gajos
K. Zaczkowski
A. Szulia
M. Grzegorczyk
A. Dąbkowska
R. Wójcik
E. J. Bobeff
K. Kwiecień
M. G. Brandel
A. Fahlström
A. Bogucki
B. Ciszek
D. J. Jaskólski
Publikationsdatum: 01.12.2024
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 1/2024
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-024-06006-0

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