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Clinical Neuroradiology
Erschienen in: Clinical Neuroradiology 4/2016

20.11.2015 | REVIEW ARTICLE

Physics, Techniques and Review of Neuroradiological Applications of Diffusion Kurtosis Imaging (DKI)

verfasst von: M. Marrale, PhD, G. Collura, MSc, Prof M. Brai, N. Toschi, PhD, F. Midiri, G. La Tona, MD, A. Lo Casto, MD, C. Gagliardo, MD, PhD

Erschienen in: Clinical Neuroradiology | Ausgabe 4/2016

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Abstract

In recent years many papers about diagnostic applications of diffusion tensor imaging (DTI) have been published. This is because DTI allows to evaluate in vivo and in a non-invasive way the process of diffusion of water molecules in biological tissues. However, the simplified description of the diffusion process assumed in DTI does not permit to completely map the complex underlying cellular components and structures, which hinder and restrict the diffusion of water molecules. These limitations can be partially overcome by means of diffusion kurtosis imaging (DKI). The aim of this paper is the description of the theory of DKI, a new topic of growing interest in radiology. DKI is a higher order diffusion model that is a straightforward extension of the DTI model. Here, we analyze the physics underlying this method, we report our MRI acquisition protocol with the preprocessing pipeline used and the DKI parametric maps obtained on a 1.5 T scanner, and we review the most relevant clinical applications of this technique in various neurological diseases.
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Metadaten
Titel
Physics, Techniques and Review of Neuroradiological Applications of Diffusion Kurtosis Imaging (DKI)
verfasst von
M. Marrale, PhD
G. Collura, MSc
Prof M. Brai
N. Toschi, PhD
F. Midiri
G. La Tona, MD
A. Lo Casto, MD
C. Gagliardo, MD, PhD
Publikationsdatum
20.11.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Neuroradiology / Ausgabe 4/2016
Print ISSN: 1869-1439
Elektronische ISSN: 1869-1447
DOI
https://doi.org/10.1007/s00062-015-0469-9

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