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ADHD Attention Deficit and Hyperactivity Disorders

Erschienen in:

01.06.2012 | Original Article

Pilot study: potential transcription markers for adult attention-deficit hyperactivity disorder in whole blood

verfasst von: Edna Grünblatt, Julia Geißler, Christian P. Jacob, Tobias Renner, Maja Müller, Jasmin Bartl, Silke Gross-Lesch, Peter Riederer, Klaus-Peter Lesch, Susanne Walitza, Manfred Gerlach, Angelika Schmitt

Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders | Ausgabe 2/2012

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Abstract

Attention-deficit hyperactivity disorder (ADHD) is a common behavioural disorder that affects not only children and adolescents but also adults; however, diagnosis of adult ADHD is difficult because patients seem to have reduced externalized behaviour. ADHD is a multifactorial disorder in which many genes, all with small effects, are thought to cause the disorder in the presence of unfavourable environmental conditions. Therefore, in this pilot study, we explored the expression profile of a list of previously established candidate genes in peripheral blood samples from adult ADHD subjects (n = 108) and compared these results with those of healthy controls (n = 35). We demonstrate that combining the gene expression levels of dopamine transporter (SLC6A3), dopamine D5 receptor, tryptophan hydroxylase-1, and SNAP25 as predictors in a regression model resulted in sensitivity and specificity of over 80 % (ROC: max R ² = 0.587, AUC = 0.917, P < 0.001, 95 % CI: 0.900–0.985). In conclusion, the combination of these four genes could represent a potential method for estimating risk and could be of diagnostic value for ADHD. Nevertheless, further investigation in a larger independent population including different subtypes of ADHD (inattentive, hyperactive, or combined type) patients is required to obtain more specific sets of biomarkers for each subtype as well as to differentiate between child, adolescent, and adulthood forms.

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Titel: Pilot study: potential transcription markers for adult attention-deficit hyperactivity disorder in whole blood
verfasst von: Edna Grünblatt
Julia Geißler
Christian P. Jacob
Tobias Renner
Maja Müller
Jasmin Bartl
Silke Gross-Lesch
Peter Riederer
Klaus-Peter Lesch
Susanne Walitza
Manfred Gerlach
Angelika Schmitt
Publikationsdatum: 01.06.2012
Verlag: Springer Vienna
Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders / Ausgabe 2/2012
Print ISSN: 1866-6116
Elektronische ISSN: 1866-6647
DOI: https://doi.org/10.1007/s12402-012-0074-6

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