Background
Methods
Research design and methods
Statistical analysis
Results
General descriptive data
Variable |
N(%) or Mean ± SD | P value d (Cohen’s value) and/or OR (95CI) | Chi- Square value (X
2) Or t-test value | ||
---|---|---|---|---|---|
Total | Male | Female | |||
250 (100%) | 182 (73.8%) | 68 (27.2%) | |||
Age (years)
| 41.9 ± 11.8 | 42.5 ± 11.5 | 40.3 ± 12.4 | 0.2a
| |
d = 0.18 | −1.3 | ||||
Education
| 0.4b
| ||||
≤ School education | 213 (85.2%) | 153 (84.1) | 60 (88.2) | 1.4 (0.62 – 3.3) | |
College education | 37 (14.8%) | 29 (15.9) | 8 (11.8) | d = 0.18 | 0.68 |
Marital Status
| <0.01 b
| ||||
Married | 138 (55.2%) | 88 (48.4) | 50 (73.5) | 3 (1.6 – 5.5) | |
Single/Divorced | 112 (44.8%) | 94 (51.6) | 18 (26.5) | d = 0.61 | 12.7 |
Smoker
| < 0.01 b
| ||||
Yes | 153 (61.2%) | 55 (80.9) | 42 (23.1) | 14.1 (7 – 28.3) | |
No | 97 (38.8%) | 13 (19.1) | 140 (76.9) | d = 1.46 | 69.66 |
Occupation
| 0.1 b
| ||||
Not working | 219 (87.6%) | 156 (85.7) | 63 (92.6) | 2.1 (0.8 – 5.7) | |
Working | 31 (12.4%) | 26 (14.3) | 5 (7.4) | d = 0.41 | 2.2 |
Duration of psychiatric illness
| 15.8 ± 9.3 | 16.2 ± 9.0 | 14.8 ± 9.9 | 0.3 a
| |
d = 0.15 | −1.01 | ||||
Waist Circumference
| < 0.01 b
| ||||
Normal | 137 (54.4) | 124 (68.1%) | 12 (17.6%) | 0.1 (0.05 – 0.2) | |
Above Normal | 114 (45.6%) | 58 (31.9%) | 56 (82.4%) | d = −1.27 | 50.86 |
Systolic Blood Pressure
| 124.2 ±14.4 | 125.1 ± 14.1 | 121.8 ± 15 | 0.1 a
| −1.6 |
d = 0.23 | |||||
Diastolic Blood Pressure
| 75.5 ± 10.8 | 76.4 ± 10.2 | 73 ± 12.1 | 0.04 a
| −2.0 |
d = 0.3 | |||||
Triglycerides
| 193.2 ± 180.2 | 187.3 ± 125.4 | 208.8 ± 279 | 0.5 a
| 0.6 |
d = −0.1 | |||||
HDL-C
| 44.9 ± 10.9 | 43.8 ± 11 | 46.4 ± 10.6 | 0.1 a
| 1.7 |
d = −0.24 | |||||
FPG
| 99.5 ± 47.5 | 96.6 ± 45.3 | 107.3 ± 52.6 | 0.1 a
| 1.5 |
d = −0.2 | |||||
CPZeq
| 436.9 ± 275.6 | 455.6 ± 283.7 | 386.8 ± 247.7 | 0.07 a
| −1.9 |
d = 0.3 | |||||
Olanzapine/Clozapine
| 0.9 b
| ||||
Yes | 30 (12) | 22 (12.1) | 8 (11.8) | 1.2 (0.6 – 2.3) | 0.18 |
No | 220 (88) | 160 (87.9) | 60 (88.2) | d = 0.1 | |
Drug regimen
| 0.1 b
| ||||
Monotherapy | 124 (49.6) | 85 (46.7) | 39 (57.4) | 1.5 (0.9 – 2.7) | 2.2 |
Combination therapy | 126 (50.4) | 97 (53.3) | 29 (42.6) | d = 0.22 |
Prevalence of metabolic syndrome
Number of MS criteria | N (%) | Gender | |
---|---|---|---|
Male | Female | ||
0 | 22 (8.8%) | 21(11.5%) | 1 (1.5%) |
1 | 56 (22.4%) | 46 (25.3%) | 10 (14.7%) |
2 | 63 (25.2%) | 44 (24.2%) | 19 (27.9%) |
3 | 52 (20.8%) | 38 (20.9%) | 14 (20.6%) |
4 | 47 (18.8%) | 28 (15.4%) | 19 (27.9%) |
5 | 10 (4%) | 5 (2.7%) | 5 (7.4%) |
MS ≥ 3 | 109 (43.6%) | 71 (39%) | 38 (55.9%) |
Variable | With MS N(%) or Mean ± SD | Without MS N(%) or Mean ± SD | Unadjusted OR (95% CI) | Adjusted OR (95% CI) |
---|---|---|---|---|
Age (years) | 45.1 ± 10.4 | 39.5 ± 12.2 | 1.04 (1.02 –1.07) | 0.98 (0.93 – 1.03) |
Gender
| ||||
Female | 38 (55.9%) | 30 (44.1%) | 2 (1.1 – 3.5) | 1.91 (0.64 – 5.69) |
Male | 71 (39%) | 111 (61%) | ||
Duration
| ||||
< 10 years | 90 (42.3%) | 123 (57.7%) | 2.2 (1.3 – 3.8) | 1.94 (0.62 – 6.01) |
>10 years | 19 (51.4) | 18 (48.6%) | ||
Smoking
| ||||
Yes | 55 (35.1%) | 98 (64.9%) | 2.2 (1.3 – 3.8) | 2.16 (0.82 – 5.69) |
No | 54 (55.7%) | 43 (44.3%) | ||
Marital status
| ||||
Married | 53 (47.3%) | 59 (52.7%) | 0.76 (0.46 – 1.25) | – |
Single | 56 (40.6%) | 82 (59.4%) | ||
Education
| ||||
< 12 years | 90 (42.3%) | 123 (57.7%) | 1.4 (0.7 – 2.9) | – |
>12 years | 19 (51.4%) | 18 (48.6%) | ||
Occupation
| ||||
Employed | 12 (38.7%) | 19 (61.3%) | 0.8 (0.36 – 1.7) | – |
Unemployed | 97 (44.3%) | 122 (55.7%) | ||
Family history of DM
| ||||
Yes | 52 (46.4%) | 60 (53.6%) | 1.2(0.75 – 2.04) | – |
No | 57 (41.3%) | 81 (57.7%) | ||
CPZeq (mg) | 432 ± 284.3 | 440.6 ± 269.7 | 1(0.9 – 1) | – |
Therapeutic Regimen
| ||||
Monotherapy | 53 (42.7%) | 71 (57.3%) | 1.07(0.65 – 1.8) | – |
Combination | 56 (44.4%) | 70 (55.6%) | ||
Depot antipsychotic
| ||||
Yes | 68 (49.3) | 70 (50.7%) | 1.7 (1.01 – 2.8) | 1.74 (0.73 – 4.14) |
No | 41 (36.6%) | 71 (63.4%) | ||
Olanzpine/Clozapine
| ||||
Yes | 10 (33.3%) | 20 (66.7%) | 0.61 (0.3 – 1.4) | – |
No | 99 (45%) | 121 (55%) | ||
WC (cm) | 105.1 ± 13.2 | 92.3 ± 10.7 | 1.1 (1.07 – 1.1) | 1.09 (1.05 – 1.13) |
Systolic BP (mmHg) | 131.1 ± 12.9 | 118.9 ± 13.2 | 1.07 (1.05 – 1.1) | 1.11 (1.07 – 1.16) |
Diastolic BP (mmHg) | 78.4 ± 10.1 | 73.2 ± 10.9 | 1.05 (1.02 – 1.07) | 0.96 (0.92 – 1.01) |
TG (mg/dl) | 256.4 ± 224.6 | 144.3 ± 115.4 | 1 (1 – 1) | 1.01 (1.0 – 1.01) |
HDL (mg/dl) | 42.4 ± 11.8 | 46.2 ± 9.9 | 0.96 (0.94 – 0.99) | 0.95 (0.91 – 1.00) |
LDL (mg/dl) | 121.7 ± 36.8 | 112.1 ± 39.1 | 1 (1 – 1.01) | |
FPG (mg/dl) | 120.5 ± 64.5 | 83.3 ± 13.9 | 1.05 (1.03 – 1.07) | 1.06 (1.03 - 1.09) |
MS ATP-III A | All Frequency (%) | Male | Female | OR (95% CI) and d (Cohen’s value) | P | Chi-Square value |
---|---|---|---|---|---|---|
WC (M > 102 cm; F > 88 cm) | 114 (45.6%) | 58 (31.9%) | 56 (82.4%) | 0.1 (0.05 – 0.2) d = −1.3 | <0.01 | 50.9 |
FPG (≥100 mg/dL) | 80 (32%) | 52 (28.6%) | 28 (41.2%) | 0.6 (0.3 – 1.02) d = −0.28 | 0.06 | 3.6 |
HDL (M < 40 mg/dl; F < 50 mg/dl) | 130 (52%) | 87 (47.8%) | 43 (63.2%) | 0.53 (0.3 – 0.94) d = −0.35 | 0.03 | 4.7 |
BP (≥ 130/85 mmHg) | 129 (51.6%) | 92 (50.5%) | 31 (45.6%) | 1.2 (0.68 – 2.1) d = 0.1 | 0.55 | 0.35 |
TG (> 150 mg/dl) | 123 (49.2%) | 96 (52.7%) | 33 (48.5%) | 1.2 (0.7 – 2.1) d = 0.1 | 0.5 | 0.49 |