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26.02.2016 | Original Paper

Prevalence of severe mitral regurgitation eligible for edge-to-edge mitral valve repair (MitraClip)

verfasst von: Julia Wallenborn, Stefan Störk, Sebastian Herrmann, Olga Kukuy, Georg Fette, Frank Puppe, Armin Gorski, Kai Hu, Wolfram Voelker, Georg Ertl, Frank Weidemann

Erschienen in: Clinical Research in Cardiology | Ausgabe 8/2016

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Abstract

Objectives

We assessed the prevalence of moderately severe or severe mitral regurgitation (MR) justifying edge-to-edge mitral valve (MV) repair (MitraClip^®) in patients attending the University Hospital Wuerzburg, a tertiary care centre located in Wuerzburg, Germany.

Background

Transcatheter edge-to-edge MV repair of advanced MR is a non-surgical treatment option in inoperable and high-risk patients. It is unknown how many patients are potentially eligible for MitraClip^® since several anatomical prerequisites of the MV apparatus have to be met for optimal treatment results.

Methods

Using a novel clinical data warehouse we searched for all patients attached to our Department of Internal Medicine from 01/2008 to 01/2012 with moderately severe or severe MR and aged ≥18 years. The current status of their treatment regime and eligibility for MitraClip^® was assessed and re-evaluated according to current guidelines and echocardiographic criteria.

Results

The search of electronic medical records amongst 43,690 patients employed an innovative validated text extraction method and identified 331 patients with moderately severe or severe MR who had undergone echocardiographic assessment at our institution. Of these, 125 (38 %) received MV surgery and 206 (62 %) medical therapy only. Most patients not undergoing surgery had secondary MR (70 %). After evaluation of medical and echocardiographic data of medically treated patients (n = 206), 81 (39 %) were potential candidates for MitraClip^® therapy, and 90 (44 %) died during the median follow-up time of 23 months.

Conclusion

A large fraction of patients with moderately severe or severe MR but not operated was detected. Medically treated patients had a bad prognosis and about 40 % of them were potential candidates for MitraClip^® therapy.

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Titel: Prevalence of severe mitral regurgitation eligible for edge-to-edge mitral valve repair (MitraClip)
verfasst von: Julia Wallenborn
Stefan Störk
Sebastian Herrmann
Olga Kukuy
Georg Fette
Frank Puppe
Armin Gorski
Kai Hu
Wolfram Voelker
Georg Ertl
Frank Weidemann
Publikationsdatum: 26.02.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Research in Cardiology / Ausgabe 8/2016
Print ISSN: 1861-0684
Elektronische ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-016-0975-z

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Prevalence of severe mitral regurgitation eligible for edge-to-edge mitral valve repair (MitraClip)

Abstract

Objectives

Background

Methods

Results

Conclusion

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Springer Medizin

Abstract

Objectives

Background

Methods

Results

Conclusion

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