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Journal of Cancer Research and Clinical Oncology
Erschienen in: Journal of Cancer Research and Clinical Oncology 7/2014

01.07.2014 | Original Article – Clinical Oncology

Prognostic significance of serum lactate dehydrogenase level in osteosarcoma: a meta-analysis

verfasst von: Jian Chen, Meng-xiong Sun, Ying-qi Hua, Zheng-dong Cai

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 7/2014

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Abstract

Background

A number of studies have investigated the role of serum lactate dehydrogenase (LDH) level in patients with osteosarcoma but have yielded inconsistent and inconclusive results. Thus, we conducted a meta-analysis to assess its prognostic value more precisely.

Methods

Systematic computerized searches of PubMed, Embase and Web of Science databases were performed. The pooled hazard ratio (HR) with 95 % confidence intervals (95 % CI) of overall survival was used to assess the prognostic role of serum LDH level.

Results

Ten studies published between 1997 and 2013 with a total of 943 osteosarcoma patients were included. Overall, the pooled HR for all ten eligible studies evaluating high LDH level on overall survival was 1.92(95 % CI 1.53–2.40). Sensitivity analysis suggested that the pooled HR was stable and omitting a single study did not change the significance of the pooled HR. Funnel plots and Egger’s tests revealed there was some possibility of publication bias risk in the meta-analysis.

Conclusion

This meta-analysis shows that high serum LDH level is obviously associated with lower overall survival rate in patients with osteosarcoma, and it is an effective biomarker of prognosis.
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Metadaten
Titel
Prognostic significance of serum lactate dehydrogenase level in osteosarcoma: a meta-analysis
verfasst von
Jian Chen
Meng-xiong Sun
Ying-qi Hua
Zheng-dong Cai
Publikationsdatum
01.07.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 7/2014
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-014-1644-0

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