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Neurotherapeutics

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01.04.2015 | Review

Recent Advances and the Future of Stem Cell Therapies in Amyotrophic Lateral Sclerosis

verfasst von: Stephen A. Goutman, Kevin S. Chen, Eva L. Feldman

Erschienen in: Neurotherapeutics | Ausgabe 2/2015

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Abstract

Amyotrophic lateral sclerosis is a progressive neurodegenerative disease of the motor neurons without a known cure. Based on the possibility of cellular neuroprotection and early preclinical results, stem cells have gained widespread enthusiasm as a potential treatment strategy. Preclinical models demonstrate a protective role of engrafted stem cells and provided the basis for human trials carried out using various types of stem cells, as well as a range of cell delivery methods. To date, no trial has demonstrated a clear therapeutic benefit; however, results remain encouraging and are the basis for ongoing studies. In addition, stem cell technology continues to improve, and induced pluripotent stem cells may offer additional therapeutic options in the future. Improved disease models and clinical trials will be essential in order to validate stem cells as a beneficial therapy.

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Robberecht, W. and T. Philips, The changing scene of amyotrophic lateral sclerosis. Nat Rev Neurosci, 2013. 14(4): p. 248–64.PubMed

Ringholz, G.M., et al., Prevalence and patterns of cognitive impairment in sporadic ALS. Neurology, 2005. 65(4): p. 586–590.PubMed

Goutman, S.A., et al., Minorities, men, and unmarried amyotrophic lateral sclerosis patients are more likely to die in an acute care facility. Amyotroph Lateral Scler Frontotemporal Degener, 2014. 15(5–6): p. 440–3.PubMed

Renton, A.E., A. Chio, and B.J. Traynor, State of play in amyotrophic lateral sclerosis genetics. Nat Neurosci, 2014. 17(1): p. 17–23.PubMed

Bensimon, G., L. Lacomblez, and V. Meininger, A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N Engl J Med, 1994. 330(9): p. 585–91.PubMed

Sorenson, E.J., et al., Subcutaneous IGF-1 is not beneficial in 2-year ALS trial. Neurology, 2008. 71(22): p. 1770–5.PubMedCentralPubMed

Miller, R.G., et al., Phase III randomized trial of gabapentin in patients with amyotrophic lateral sclerosis. Neurology, 2001. 56(7): p. 843–8.PubMed

Gage, F.H., Mammalian neural stem cells. Science, 2000. 287(5457): p. 1433–8.PubMed

Temple, S., The development of neural stem cells. Nature, 2001. 414(6859): p. 112–7.PubMed

10.

Boulis, N.M., et al., Translational stem cell therapy for amyotrophic lateral sclerosis. Nat Rev Neurol, 2011. 8(3): p. 172–6.PubMed

11.

Lopez-Gonzalez, R., P. Kunckles, and I. Velasco, Transient recovery in a rat model of familial amyotrophic lateral sclerosis after transplantation of motor neurons derived from mouse embryonic stem cells. Cell Transplant, 2009. 18(10): p. 1171–81.PubMed

12.

Maragakis, N.J., Stem cells and the ALS neurologist. Amyotroph Lateral Scler, 2010. 11(5): p. 417–23.PubMed

13.

Lunn, J.S., S.A. Sakowski, and E.L. Feldman, Concise review: Stem cell therapies for amyotrophic lateral sclerosis: recent advances and prospects for the future. Stem Cells, 2014. 32(5): p. 1099–109.PubMedCentralPubMed

14.

Guo, X., et al., Characterization of a human fetal spinal cord stem cell line, NSI-566RSC, and its induction to functional motoneurons. J Tissue Eng Regen Med 2010. 4(3): p. 181–193.PubMedCentralPubMed

15.

Deshpande, D.M., et al., Recovery from paralysis in adult rats using embryonic stem cells. Ann Neurol, 2006. 60(1): p. 32–44.PubMed

16.

Harper, J.M., et al., Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats. Proc Natl Acad Sci U S A, 2004. 101(18): p. 7123–8.PubMedCentralPubMed

17.

Kerr, D.A., et al., Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury. J Neurosci, 2003. 23(12): p. 5131–40.PubMed

18.

Corti, S., et al., Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues. Brain, 2004. 127(Pt 11): p. 2518–32.PubMed

19.

Solomon, J.N., et al., Origin and distribution of bone marrow-derived cells in the central nervous system in a mouse model of amyotrophic lateral sclerosis. Glia, 2006. 53(7): p. 744–53.PubMed

20.

Ohnishi, S., et al., Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis. Brain Res, 2009. 1296: p. 216–24.PubMed

21.

Pastor, D., et al., Bone marrow transplantation in hindlimb muscles of motoneuron degenerative mice reduces neuronal death and improves motor function. Stem Cells Dev, 2013. 22(11): p. 1633–44.PubMedCentralPubMed

22.

Cabanes, C., et al., Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration. Neurobiol Dis, 2007. 26(2): p. 408–18.PubMed

23.

Corti, S., et al., Systemic transplantation of c-kit+ cells exerts a therapeutic effect in a model of amyotrophic lateral sclerosis. Hum Mol Genet, 2010. 19(19): p. 3782–96.PubMed

24.

Pastor, D., et al., Comparative effects between bone marrow and mesenchymal stem cell transplantation in GDNF expression and motor function recovery in a motorneuron degenerative mouse model. Stem Cell Rev, 2012. 8(2): p. 445–58.PubMed

25.

Garbuzova-Davis, S., et al., Human umbilical cord blood treatment in a mouse model of ALS: optimization of cell dose. PLoS One, 2008. 3(6): p. e2494.PubMedCentralPubMed

26.

Garbuzova-Davis, S., et al., Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: distribution, migration, and differentiation. J Hematother Stem Cell Res, 2003. 12(3): p. 255–70.PubMed

27.

Souayah, N., et al., Defective neuromuscular transmission in the SOD1 G93A transgenic mouse improves after administration of human umbilical cord blood cells. Stem Cell Rev, 2012. 8(1): p. 224–8.PubMed

28.

Bigini, P., et al., Intracerebroventricular administration of human umbilical cord blood cells delays disease progression in two murine models of motor neuron degeneration. Rejuvenation Res, 2011. 14(6): p. 623–39.PubMed

29.

Knippenberg, S., et al., Intraspinal injection of human umbilical cord blood-derived cells is neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis. Neurodegener Dis, 2012. 9(3): p. 107–20.PubMed

30.

Rizvanov, A.A., et al., Genetically modified human umbilical cord blood cells expressing vascular endothelial growth factor and fibroblast growth factor 2 differentiate into glial cells after transplantation into amyotrophic lateral sclerosis transgenic mice. Exp Biol Med (Maywood), 2011. 236(1): p. 91–8.

31.

Rizvanov, A.A., et al., Human umbilical cord blood cells transfected with VEGF and L(1)CAM do not differentiate into neurons but transform into vascular endothelial cells and secrete neuro-trophic factors to support neuro-genesis-a novel approach in stem cell therapy. Neurochem Int, 2008. 53(6–8): p. 389–94.PubMed

32.

Habisch, H.J., et al., Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS: limited intraparenchymal migration and survival narrows therapeutic effects. J Neural Transm, 2007. 114(11): p. 1395–406.PubMed

33.

Uccelli, A., et al., Intravenous mesenchymal stem cells improve survival and motor function in experimental amyotrophic lateral sclerosis. Mol Med, 2012. 18: p. 794–804.PubMedCentralPubMed

34.

Forostyak, S., et al., Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis. Cytotherapy, 2011. 13(9): p. 1036–46.PubMed

35.

Boucherie, C., et al., Chimerization of astroglial population in the lumbar spinal cord after mesenchymal stem cell transplantation prolongs survival in a rat model of amyotrophic lateral sclerosis. J Neurosci Res, 2009. 87(9): p. 2034–46.PubMed

36.

Zhao, C.P., et al., Human mesenchymal stromal cells ameliorate the phenotype of SOD1-G93A ALS mice. Cytotherapy, 2007. 9(5): p. 414–26.PubMed

37.

Vercelli, A., et al., Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis. Neurobiol Dis, 2008. 31(3): p. 395–405.PubMed

38.

Kim, H., et al., Dose-dependent efficacy of ALS-human mesenchymal stem cells transplantation into cisterna magna in SOD1-G93A ALS mice. Neurosci Lett, 2010. 468(3): p. 190–4.PubMed

39.

Suzuki, M., et al., Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS. Mol Ther, 2008. 16(12): p. 2002–10.PubMedCentralPubMed

40.

Knippenberg, S., et al., Intracerebroventricular injection of encapsulated human mesenchymal cells producing glucagon-like peptide 1 prolongs survival in a mouse model of ALS. PLoS One, 2012. 7(6): p. e36857.PubMedCentralPubMed

41.

Chan-Il, C., et al., Neural induction with neurogenin 1 enhances the therapeutic potential of mesenchymal stem cells in an amyotrophic lateral sclerosis mouse model. Cell Transplant, 2013. 22(5): p. 855–70.PubMed

42.

Morita, E., et al., A novel cell transplantation protocol and its application to an ALS mouse model. Exp Neurol, 2008. 213(2): p. 431–8.PubMed

43.

Martin, L.J. and Z. Liu, Adult olfactory bulb neural precursor cell grafts provide temporary protection from motor neuron degeneration, improve motor function, and extend survival in amyotrophic lateral sclerosis mice. J Neuropathol Exp Neurol, 2007. 66(11): p. 1002–18.PubMed

44.

Lepore, A.C., et al., Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nat Neurosci, 2008. 11(11): p. 1294–301.PubMedCentralPubMed

45.

Lepore, A.C., et al., Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS. PLoS One, 2011. 6(10): p. e25968.PubMedCentralPubMed

46.

Corti, S., et al., Neural stem cells LewisX+ CXCR4+ modify disease progression in an amyotrophic lateral sclerosis model. Brain, 2007. 130(Pt 5): p. 1289–305.PubMed

47.

Mitrecic, D., et al., Distribution, differentiation, and survival of intravenously administered neural stem cells in a rat model of amyotrophic lateral sclerosis. Cell Transplant, 2010. 19(5): p. 537–48.PubMed

48.

Hwang, D.H., et al., Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice. Gene Ther, 2009. 16(10): p. 1234–44.PubMed

49.

Park, S., et al., Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice. Exp Mol Med, 2009. 41(7): p. 487–500.PubMedCentralPubMed

50.

Xu, L., et al., Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats. Transplantation, 2006. 82(7): p. 865–75.PubMed

51.

Xu, L., et al., Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: differentiation and structural integration into the segmental motor circuitry. J Comp Neurol, 2009. 514(4): p. 297–309.PubMedCentralPubMed

52.

Yan, J., et al., Combined immunosuppressive agents or CD4 antibodies prolong survival of human neural stem cell grafts and improve disease outcomes in amyotrophic lateral sclerosis transgenic mice. Stem Cells, 2006. 24(8): p. 1976–85.PubMed

53.

Klein, S.M., et al., GDNF delivery using human neural progenitor cells in a rat model of ALS. Hum Gene Ther, 2005. 16(4): p. 509–21.PubMed

54.

Suzuki, M., et al., GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS. PLoS One, 2007. 2(8): p. e689.PubMedCentralPubMed

55.

Garbuzova-Davis, S., et al., Positive effect of transplantation of hNT neurons (NTera 2/D1 cell-line) in a model of familial amyotrophic lateral sclerosis. Exp Neurol, 2002. 174(2): p. 169–80.PubMed

56.

Gao, J., et al., Human neural stem cell-derived cholinergic neurons innervate muscle in motoneuron deficient adult rats. Neuroscience, 2005. 131(2): p. 257–62.PubMed

57.

Xu, L., et al., Dual transplantation of human neural stem cells into cervical and lumbar cord ameliorates motor neuron disease in SOD1 transgenic rats. Neurosci Lett, 2011. 494(3): p. 222–6.PubMedCentralPubMed

58.

Hefferan, M.P., et al., Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation. PLoS One, 2012. 7(8): p. e42614.PubMedCentralPubMed

59.

Popescu, I.R., et al., Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis. Stem Cells Transl Med, 2013. 2(3): p. 167–74.PubMedCentralPubMed

60.

Nizzardo, M., et al., Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model. Hum Mol Genet, 2014. 23(2): p. 342–54.PubMedCentralPubMed

61.

Zhang, Y., et al., Preliminary investigation of effect of granulocyte colony stimulating factor on amyotrophic lateral sclerosis. Amyotroph Lateral Scler, 2009. 10(5–6): p. 430–1.PubMed

62.

Nefussy, B., et al., Recombinant human granulocyte-colony stimulating factor administration for treating amyotrophic lateral sclerosis: A pilot study. Amyotroph Lateral Scler, 2010. 11(1–2): p. 187–93.PubMed

63.

Tarella, C., et al., Consistent bone marrow-derived cell mobilization following repeated short courses of granulocyte-colony-stimulating factor in patients with amyotrophic lateral sclerosis: results from a multicenter prospective trial. Cytotherapy, 2010. 12(1): p. 50–9.PubMed

64.

Chio, A., et al., Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: clinical and biological results from a prospective multicenter study. Muscle Nerve, 2011. 43(2): p. 189–95.PubMed

65.

Cashman, N., et al., Pilot study of granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood stem cells in amyotrophic lateral sclerosis (ALS). Muscle Nerve, 2008. 37(5): p. 620–5.PubMed

66.

Janson, C.G., et al., Human intrathecal transplantation of peripheral blood stem cells in amyotrophic lateral sclerosis. J Hematother Stem Cell Res, 2001. 10(6): p. 913–5.PubMed

67.

Appel, S.H., et al., Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis. Neurology, 2008. 71(17): p. 1326–34.PubMed

68.

Martinez, H.R., et al., Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients. Cytotherapy, 2009. 11(1): p. 26–34.PubMed

69.

Martinez, H.R., et al., Stem cell transplantation in amyotrophic lateral sclerosis patients: methodological approach, safety, and feasibility. Cell Transplant, 2012. 21(9): p. 1899–907.PubMed

70.

Karussis, D., et al., Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. Arch Neurol, 2010. 67(10): p. 1187–94.PubMedCentralPubMed

71.

Prabhakar, S., et al., Autologous bone marrow-derived stem cells in amyotrophic lateral sclerosis: a pilot study. Neurol India, 2012. 60(5): p. 465–9.PubMed

72.

Baek, W., et al., Stem cell transplantation into the intraventricular space via an Ommaya reservoir in a patient with amyotrophic lateral sclerosis. J Neurosurg Sci, 2012. 56(3): p. 261–3.PubMed

73.

Mazzini, L., et al., Autologous mesenchymal stem cells: clinical applications in amyotrophic lateral sclerosis. Neurol Res, 2006. 28(5): p. 523–6.PubMed

74.

Mazzini, L., et al., Stem cell treatment in Amyotrophic Lateral Sclerosis. J Neurol Sci, 2008. 265(1–2): p. 78–83.PubMed

75.

Mazzini, L., et al., Mesenchymal stromal cell transplantation in amyotrophic lateral sclerosis: a long-term safety study. Cytotherapy, 2012. 14(1): p. 56–60.PubMed

76.

Mazzini, L., et al., Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial. Exp Neurol, 2010. 223(1): p. 229–37.PubMed

77.

Blanquer, M., et al., A surgical technique of spinal cord cell transplantation in amyotrophic lateral sclerosis. J Neurosci Methods, 2010. 191(2): p. 255–7.PubMed

78.

Blanquer, M., et al., Neurotrophic Bone Marrow Cellular Nests Prevent Spinal Motoneuron Degeneration in Amyotrophic Lateral Sclerosis Patients: A Pilot Safety Study. STEM CELLS, 2012. 30(6): p. 1277–1285.PubMed

79.

Deda, H., et al., Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up. Cytotherapy, 2009. 11(1): p. 18–25.PubMed

80.

Moviglia, G.A., et al., Feasibility, safety, and preliminary proof of principles of autologous neural stem cell treatment combined with T-cell vaccination for ALS patients. Cell Transplant, 2012. 21 Suppl 1: p. S57-63.PubMed

81.

Piepers, S. and L.H. van den Berg, No benefits from experimental treatment with olfactory ensheathing cells in patients with ALS. Amyotroph Lateral Scler, 2010. 11(3): p. 328–30.PubMed

82.

Chew, S., et al., Olfactory ensheathing glia injections in Beijing: misleading patients with ALS. Amyotroph Lateral Scler, 2007. 8(5): p. 314–6.PubMed

83.

Giordana, M.T., et al., Neuropathology of olfactory ensheathing cell transplantation into the brain of two amyotrophic lateral sclerosis (ALS) patients. Brain Pathol, 2010. 20(4): p. 730–7.PubMed

84.

Huang, H., et al., Fetal olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients: a controlled pilot study. Clin Transplant, 2008. 22(6): p. 710–8.PubMed

85.

Chen, L., et al., Short-term outcome of olfactory ensheathing cells transplantation for treatment of amyotrophic lateral sclerosis. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2007. 21(9): p. 961–6.PubMed

86.

Chen, L., et al., Olfactory ensheathing cell neurorestorotherapy for amyotrophic lateral sclerosis patients: benefits from multiple transplantations. Cell Transplant, 2012. 21 Suppl 1: p. S65-77.PubMed

87.

Riley, J., et al., Intraspinal stem cell transplantation in amyotrophic lateral sclerosis: a phase I safety trial, technical note, and lumbar safety outcomes. Neurosurgery, 2012. 71(2): p. 405–16; discussion 416.PubMed

88.

Glass, J.D., et al., Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients. Stem Cells, 2012. 30(6): p. 1144–51.PubMed

89.

Riley, J., et al., Intraspinal stem cell transplantation in amyotrophic lateral sclerosis: a phase I trial, cervical microinjection, and final surgical safety outcomes. Neurosurgery, 2014. 74(1): p. 77–87.PubMed

90.

Tadesse T, et al. Analysis of graft survival in a trial of stem cell transplant in ALS. Ann Clin Transl Neurol 2014; p. n/a-n/a

91.

Feldman, E.L., et al., Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: phase 1 trial outcomes. Ann Neurol, 2014. 75(3): p. 363–73.PubMedCentralPubMed

92.

Rosen, D.R., et al., Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature, 1993. 362(6415): p. 59–62.PubMed

93.

Ende, N., et al., Human umbilical cord blood effect on sod mice (amyotrophic lateral sclerosis). Life Sci, 2000. 67(1): p. 53–9.PubMed

94.

Chen, R. and N. Ende, The potential for the use of mononuclear cells from human umbilical cord blood in the treatment of amyotrophic lateral sclerosis in SOD1 mice. J Med, 2000. 31(1–2): p. 21–30.PubMed

95.

Wichterle, H., et al., Directed differentiation of embryonic stem cells into motor neurons. Cell, 2002. 110(3): p. 385–97.PubMed

96.

Ilieva, H., M. Polymenidou, and D.W. Cleveland, Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol, 2009. 187(6): p. 761–72.PubMedCentralPubMed

97.

Boillee, S., et al., Onset and progression in inherited ALS determined by motor neurons and microglia. Science, 2006. 312(5778): p. 1389–92.PubMed

98.

Borchelt, D.R., Amyotrophic lateral sclerosis–are microglia killing motor neurons? N Engl J Med, 2006. 355(15): p. 1611–3.PubMed

99.

Clement, A.M., et al., Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science, 2003. 302(5642): p. 113–7.PubMed

100.

Yamanaka, K., et al., Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat Neurosci, 2008. 11(3): p. 251–3.PubMedCentralPubMed

101.

Krakora, D., et al., Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model. Mol Ther, 2013. 21(8): p. 1602–10.PubMedCentralPubMed

102.

Beers, D.R., et al., Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A, 2006. 103(43): p. 16021–6.PubMedCentralPubMed

103.

Li, Y., P.M. Field, and G. Raisman, Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells. Science, 1997. 277(5334): p. 2000–2.PubMed

104.

Ramon-Cueto, A., et al., Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron, 2000. 25(2): p. 425–35.PubMed

105.

Lunn, J.S., et al., Stem cell technology for the study and treatment of motor neuron diseases. Regen Med, 2011. 6(2): p. 201–13.PubMedCentralPubMed

106.

Hubel, K. and A. Engert, Clinical applications of granulocyte colony-stimulating factor: an update and summary. Ann Hematol, 2003. 82(4): p. 207–13.PubMed

107.

Deng, J., et al., Bone marrow mesenchymal stem cells can be mobilized into peripheral blood by G-CSF in vivo and integrate into traumatically injured cerebral tissue. Neurol Sci, 2011. 32(4): p. 641–51.PubMed

108.

Tanaka, M., et al., Intrathecal upregulation of granulocyte colony stimulating factor and its neuroprotective actions on motor neurons in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol, 2006. 65(8): p. 816–25.PubMed

109.

Uccelli, A., et al., Neuroprotective features of mesenchymal stem cells. Best Pract Res Clin Haematol, 2011. 24(1): p. 59–64.PubMed

110.

Uccelli, A., L. Moretta, and V. Pistoia, Mesenchymal stem cells in health and disease. Nat Rev Immunol, 2008. 8(9): p. 726–36.PubMed

111.

Woodbury, D., et al., Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res, 2000. 61(4): p. 364–70.PubMed

112.

Sanchez-Ramos, J., et al., Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol, 2000. 164(2): p. 247–56.PubMed

113.

Bossolasco, P., et al., Neuro-glial differentiation of human bone marrow stem cells in vitro. Exp Neurol, 2005. 193(2): p. 312–25.PubMed

114.

Lu, P., A. Blesch, and M.H. Tuszynski, Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation, or artifact? J Neurosci Res, 2004. 77(2): p. 174–91.PubMed

115.

Takahashi, K., et al., Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 2007. 131(5): p. 861–72.PubMed

116.

Sareen, D., et al., Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord. J Comp Neurol, 2014. 522(12): p. 2707–28.PubMed

117.

Takahashi, K. and S. Yamanaka, Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 2006. 126(4): p. 663–76.PubMed

118.

Yu, J., et al., Induced pluripotent stem cell lines derived from human somatic cells. Science, 2007. 318(5858): p. 1917–20.PubMed

119.

Dimos, J.T., et al., Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science, 2008. 321(5893): p. 1218–21.PubMed

120.

Burkhardt, M.F., et al., A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells. Mol Cell Neurosci, 2013. 56: p. 355–64.PubMed

121.

Chestkov, I.V., et al., Patient-Specific Induced Pluripotent Stem Cells for SOD1-Associated Amyotrophic Lateral Sclerosis Pathogenesis Studies. Acta Naturae, 2014. 6(1): p. 54–60.PubMedCentralPubMed

122.

Egawa N, et al. Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med 2012; 4(145): p. 145ra104

123.

Faravelli, I., et al., Motor neuron derivation from human embryonic and induced pluripotent stem cells: experimental approaches and clinical perspectives. Stem Cell Res Ther, 2014. 5(4): p. 87.PubMed

124.

Paganoni, S., et al., Diagnostic timelines and delays in diagnosing amyotrophic lateral sclerosis (ALS). Amyotroph Lateral Scler Frontotemporal Degener, 2014. 15(5–6): p. 453–6.PubMed

125.

Simon, N.G., et al., Quantifying disease progression in amyotrophic lateral sclerosis. Ann Neurol, 2014. 76(5): p. 643–57.

126.

Foerster, B.R., R.C. Welsh, and E.L. Feldman, 25 years of neuroimaging in amyotrophic lateral sclerosis. Nat Rev Neurol, 2013. 9(9): p. 513–24.PubMedCentralPubMed

Titel: Recent Advances and the Future of Stem Cell Therapies in Amyotrophic Lateral Sclerosis
verfasst von: Stephen A. Goutman
Kevin S. Chen
Eva L. Feldman
Publikationsdatum: 01.04.2015
Verlag: Springer US
Erschienen in: Neurotherapeutics / Ausgabe 2/2015
Print ISSN: 1933-7213
Elektronische ISSN: 1878-7479
DOI: https://doi.org/10.1007/s13311-015-0339-9

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Weitere Artikel der Ausgabe 2/2015

A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis

Enhanced Retinal Ganglion Cell Survival in Glaucoma by Hypoxic Postconditioning After Disease Onset

RNA-targeted Therapeutics for ALS

Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis