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01.10.2015 | Case Report

Recipient-born bloodstream infection due to extensively drug-resistant Acinetobacter baumannii after emergency heart transplant: report of a case and review of the literature

verfasst von: Roberto Andini, Federica Agrusta, Irene Mattucci, Umberto Malgeri, Giusi Cavezza, Riccardo Utili, Emanuele Durante-Mangoni

Erschienen in: Infection | Ausgabe 5/2015

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Abstract

Infections due to drug-resistant Gram-negative rods are an emerging risk factor for increased mortality after solid organ transplant. Extensively drug-resistant (XDR) Acinetobacter baumannii (Acb) is a major threat in several critical care settings. The limited available data on the outcome of XDR Acb infections in organ transplant recipients mostly comes from cases of donor-derived infections. However, recipients of life-saving organs are often critically ill patients, staying long term in intensive care units, and therefore at high risk for nosocomial infections. In this report, we describe our experience with the exceedingly complex management of a recipient-born XDR Acb bloodstream infection clinically ensued shortly after heart transplant. We also review the current literature on this mounting issue relevant for intensive care, transplant medicine and infectious diseases.

Husain S, Mooney ML, Danziger-Isakov L, Mattner F, Singh N, Avery R. A 2010 working formulation for the standardization of definitions of infections in cardiothoracic transplant recipients. J Heart Lung Transplant. 2011;30:361–74.CrossRefPubMed

Ison MG, Grossi P. Donor-derived infections in solid organ transplantation. Am J Transplant. 2013;13:22–30.CrossRefPubMed

Bull DA, Stahll RD, McMahan DL, Jones KW, et al. The high risk heart donor: potential pitfalls. J Heart Lung Transplant. 1995;14:424–8.PubMed

Freeman RB, Giatras I, Falagas ME, et al. Outcome of transplantation of organs procured from bacteremic donors. Transplantation. 1999;68:1107–11.CrossRefPubMed

Nguyen M, Eschenauer GA, Bryan M, et al. Carbapenem-resistant Klebsiella pneumoniae bacteremia: factors correlated with clinical and microbiologic outcomes. Diagn Microbiol Infect Dis. 2010;67:180–4.CrossRefPubMed

Orlando G, Di Cocco P, Gravante G, D’Angelo M, Famulari A, Pisani F. Fatal hemorrhage in two renal graft recipients with multi-drug resistant Pseudomonas aeruginosa infection. Transplant Infect Dis. 2009;11:442–7.CrossRef

Pauly RP, Rayner D, Murray AG, Gilmour SM, Kunimoto DY. Transplantation in the face of severe donor sepsis: pushing the boundaries? Am J Kidney Dis. 2004;44:e64–7.CrossRefPubMed

Sifri CD, Ison MG. Highly resistant bacteria and donor-derived infections: treading in uncharted territory. Transplant Infect Dis. 2012;14:223–8.CrossRef

Veroux M, Corona D, Scriffignano V, et al. Contamination of preservation fluid in kidney transplantation: single-center analysis. Transplant Proc. 2010;42:1043–5.CrossRefPubMed

10.

Wakelin SJ, Casey J, Robertson A, et al. The incidence and importance of bacterial contaminants of cadaveric renal perfusion fluid. Transpl Int. 2005;17:680–6.CrossRefPubMed

11.

Watkins AC, Vedula GV, Horan J, et al. The deceased organ donor with an “open abdomen”: proceed with caution. Transplant Infect Dis. 2012;14:311–5.CrossRef

12.

Lumbreras C, Sanz F, González A, et al. Clinical significance of donor-unrecognized bacteremia in the outcome of solid-organ transplant recipients. Clin Infect Dis. 2001;33:722–6.CrossRefPubMed

13.

Magiorakos AP, Srinivasan A, Carey RB, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18:268–81.CrossRefPubMed

14.

Nunley DR, Bauldoff GS, Mangino JE, Pope-Harman AL. Mortality associated with Acinetobacter baumannii infections experienced by lung transplant recipients. Lung. 2010;188:381–5.CrossRefPubMed

15.

Durante-Mangoni E, Zarrilli R. Global spread of drug-resistant Acinetobacter baumannii: molecular epidemiology and management of antimicrobial resistance. Future Microbiol. 2011;6:407–22.CrossRefPubMed

16.

Wareham DW, Gordon NC, Hornsey M. In vitro activity of teicoplanin combined with colistin versus multidrug-resistant strains of Acinetobacter baumannii. J Antimicrob Chemother. 2011;66:1047–51.CrossRefPubMed

17.

Hornsey M, Wareham DW. In vivo efficacy of glycopeptide-colistin combination therapies in a Galleria mellonella model of Acinetobacter baumannii infection. Antimicrob Agents Chemother. 2011;55:3534–7.PubMedCentralCrossRefPubMed

18.

O’Hara JA, Ambe LA, Casella LG, Townsend BM, et al. Activities of vancomycin-containing regimens against colistin-resistant Acinetobacter baumannii clinical strains. Antimicrob Agents Chemother. 2013;57:2103–8.PubMedCentralCrossRefPubMed

19.

Durante-Mangoni E, Signoriello G, Andini R, et al. Colistin and rifampicin compared with colistin alone for the treatment of serious infections due to extensively drug-resistant Acinetobacter baumannii: a multicenter, randomized clinical trial. Clin Infect Dis. 2013;57:349–58.CrossRefPubMed

20.

Martins N, Martins IS, de Freitas WV, et al. Severe infection in a lung transplant recipient caused by donor-transmitted carbapenem-resistant Acinetobacter baumannii. Transpl Infect Dis. 2012;14:316–20.PubMedCentralCrossRefPubMed

21.

Simkins J, Muggia V. Favorable outcome in a renal transplant recipient with donor-derived infection due to multidrug-resistant Pseudomonas aeruginosa. Transpl Infect Dis. 2012;14:292–5.CrossRefPubMed

22.

Ariza-Heredia EJ, Patel R, Blumberg EA, et al. Outcomes of transplantation using organs from a donor infected with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae. Transpl Infect Dis. 2012;14:229–36.CrossRefPubMed

23.

Kumar D, Cattral MS, Robicsek A, Gaudreau C, Humar A. Outbreak of pseudomonas aeruginosa by multiple organ transplantation from a common donor. Transplantation. 2003;15:1053–5.CrossRef

24.

Goldberg E, Bishara J, Lev S, Singer P, Cohen J. Organ transplantation from a donor colonized with a multidrug-resistant organism: a case report. Transpl Infect Dis. 2012;14:296–9.CrossRefPubMed

25.

Reddy P, Zembower TR, Ison MG, Baker TA, Stosor V. Carbapenem-resistant Acinetobacter baumannii infections after organ transplantation. Transpl Infect Dis. 2010;12:87–93.CrossRefPubMed

Titel: Recipient-born bloodstream infection due to extensively drug-resistant Acinetobacter baumannii after emergency heart transplant: report of a case and review of the literature
verfasst von: Roberto Andini
Federica Agrusta
Irene Mattucci
Umberto Malgeri
Giusi Cavezza
Riccardo Utili
Emanuele Durante-Mangoni
Publikationsdatum: 01.10.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Infection / Ausgabe 5/2015
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI: https://doi.org/10.1007/s15010-015-0772-z

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