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Current Hypertension Reports

Erschienen in:

01.04.2010

Regression of Small Resistance Artery Structural Alterations in Hypertension by Appropriate Antihypertensive Treatment

verfasst von: Enrico Agabiti-Rosei, Damiano Rizzoni

Erschienen in: Current Hypertension Reports | Ausgabe 2/2010

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Abstract

Regardless of the mechanisms that initiate the rise of blood pressure, the development of structural changes in the systemic vasculature is the end result of established hypertension. Indices of small resistance artery structure, such as the ratio of tunica media to internal lumen, may have a strong prognostic significance in hypertensive patients, over and above all other known cardiovascular risk factors. Hence, the regression of vascular alterations seems to be an appealing goal for antihypertensive treatment. Different antihypertensive drugs may have different effects on vascular structure. Complete normalization of small resistance artery structure was demonstrated in hypertensive patients after long-term and effective antihypertensive therapy with angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and calcium antagonists. Little or no improvement was observed with β-blockers or diuretics. Evidence from several studies suggests that some antihypertensive drugs are more effective than others in reversing microvascular structural alterations in hypertension.

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Titel: Regression of Small Resistance Artery Structural Alterations in Hypertension by Appropriate Antihypertensive Treatment
verfasst von: Enrico Agabiti-Rosei
Damiano Rizzoni
Publikationsdatum: 01.04.2010
Verlag: Current Science Inc.
Erschienen in: Current Hypertension Reports / Ausgabe 2/2010
Print ISSN: 1522-6417
Elektronische ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-010-0093-7

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