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Zeitschrift für Rheumatologie

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19.03.2016 | Neues aus der Forschung

Recruitment of osteogenic cells to bone formation sites during development and fracture repair

verfasst von: A.-M. Böhm, N. Dirckx, C. Maes

Erschienen in: Zeitschrift für Rheumatologie | Sonderheft 1/2017

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Abstract

Recruitment of osteoblast lineage cells to their bone-forming locations is essential for skeletal development and fracture healing. In developing bones, osteoprogenitor cells invade the cartilage mold to establish the primary ossification center. Similarly, osteogenic cells infiltrate and populate the callus tissue that is formed following an injury. Proper bone development and successful fracture repair must, therefore, rely on controlled temporal and spatial navigation cues guiding the cells to the sites where new bone formation is needed. Some cellular mechanisms and molecular pathways involved have been elucidated.

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Titel: Recruitment of osteogenic cells to bone formation sites during development and fracture repair
verfasst von: A.-M. Böhm
N. Dirckx
C. Maes
Publikationsdatum: 19.03.2016
Verlag: Springer Medizin
Erschienen in: Zeitschrift für Rheumatologie / Ausgabe Sonderheft 1/2017
Print ISSN: 0340-1855
Elektronische ISSN: 1435-1250
DOI: https://doi.org/10.1007/s00393-015-1574-5

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