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European Radiology

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01.01.2013 | Neuro

Reliability of the corticospinal tract and arcuate fasciculus reconstructed with DTI-based tractography: implications for clinical practice

verfasst von: Gert Kristo, Alexander Leemans, Beatrice de Gelder, Mathijs Raemaekers, Geert-Jan Rutten, Nick Ramsey

Erschienen in: European Radiology | Ausgabe 1/2013

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Abstract

Objectives

To assess the reliability of diffusion tensor imaging (DTI)-based fibre tractography (FT), which is a prerequisite for clinical applications of this technique. Here we assess the test–retest reproducibility of the architectural and microstructural features of two clinically relevant tracts reconstructed with DTI-FT.

Methods

The corticospinal tract (CST), arcuate fasciculus (AF) and its long segment (AFl) were reconstructed in 17 healthy subjects imaged twice using a deterministic approach. Coefficients of variation (CVs) of diffusion-derived tract values were used to assess the microstructural reproducibility. Spatial correlation and fibre overlap were used to assess the architectural reproducibility.

Results

Spatial correlation was 68 % for the CST and AF, and 69 % for the AFl. Overlap was 69 % for the CST, 61 % for the AF, and 59 % for the AFl. This was comparable to 2-mm tract shift variability. CVs of diffusion-derived tract values were at most 3.4 %.

Conclusions

The results showed low architectural and microstructural variability for the reconstruction of the tracts. The architectural reproducibility results encourage the further investigation of the use of DTI-FT for neurosurgical planning. The high microstructural reproducibility results are promising for using DTI-FT in neurology to assess or predict functional recovery.

Key Points

• Magnetic resonance diffusion tensor fibre tractography is increasingly used in the neurosciences.

• The architectural reproducibility of fibre pathways can be up to 69 %.

• However the microstructural variability of fibre pathways is only 3.4 % at most.

• The architectural reproducibility results encourage the use of DTI-FT for neurosurgery.

• The microstructural reproducibility results support the use of DTI-FT in neurology.

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Titel: Reliability of the corticospinal tract and arcuate fasciculus reconstructed with DTI-based tractography: implications for clinical practice
verfasst von: Gert Kristo
Alexander Leemans
Beatrice de Gelder
Mathijs Raemaekers
Geert-Jan Rutten
Nick Ramsey
Publikationsdatum: 01.01.2013
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 1/2013
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2589-9

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