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Erschienen in: Critical Care 2/2012

01.04.2012 | Review

Repair after acute lung injury: molecular mechanisms and therapeutic opportunities

verfasst von: Adrián González-López, Guillermo M Albaiceta

Erschienen in: Critical Care | Ausgabe 2/2012

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Excerpt

Acute lung injury (ALI) is a clinical syndrome characterized by impairment in gas exchange and/or lung mechanics that leads to hypoxemia and increased work of breathing (WOB). When respiratory failure occurs, most patients require mechanical ventilation. This clinical scenario is related to high morbidity and mortality rates. …
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Literatur
1.
Zurück zum Zitat Ventrice EA, Marti-Sistac O, Gonzalvo R, Villagra A, Lopez-Aguilar J, Blanch L: [Molecular and biophysical mechanisms and modulation of ventilator-induced lung injury]. Med Intensiva 2007, 31: 73-82. 10.1016/S0210-5691(07)74779-4CrossRefPubMed Ventrice EA, Marti-Sistac O, Gonzalvo R, Villagra A, Lopez-Aguilar J, Blanch L: [Molecular and biophysical mechanisms and modulation of ventilator-induced lung injury]. Med Intensiva 2007, 31: 73-82. 10.1016/S0210-5691(07)74779-4CrossRefPubMed
2.
Zurück zum Zitat Bianchi ME: DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 2007, 81: 1-5.CrossRefPubMed Bianchi ME: DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 2007, 81: 1-5.CrossRefPubMed
3.
Zurück zum Zitat de Carvalho ME, Dolhnikoff M, Meireles SI, Reis LF, Martins MA, Deheinzelin D: Effects of overinflation on procollagen type III expression in experimental acute lung injury. Crit Care 2007, 11: R23. 10.1186/cc5702PubMedCentralCrossRefPubMed de Carvalho ME, Dolhnikoff M, Meireles SI, Reis LF, Martins MA, Deheinzelin D: Effects of overinflation on procollagen type III expression in experimental acute lung injury. Crit Care 2007, 11: R23. 10.1186/cc5702PubMedCentralCrossRefPubMed
4.
Zurück zum Zitat Armstrong L, Thickett DR, Mansell JP, et al.: Changes in collagen turnover in early acute respiratory distress syndrome. Am J Respir Crit Care Med 1999, 160: 1910-1915.CrossRefPubMed Armstrong L, Thickett DR, Mansell JP, et al.: Changes in collagen turnover in early acute respiratory distress syndrome. Am J Respir Crit Care Med 1999, 160: 1910-1915.CrossRefPubMed
5.
Zurück zum Zitat Berthiaume Y, Matthay MA: Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol 2007, 159: 350-359. 10.1016/j.resp.2007.05.010PubMedCentralCrossRefPubMed Berthiaume Y, Matthay MA: Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol 2007, 159: 350-359. 10.1016/j.resp.2007.05.010PubMedCentralCrossRefPubMed
6.
Zurück zum Zitat Bhatia M, Moochhala S: Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 2004, 202: 145-156. 10.1002/path.1491CrossRefPubMed Bhatia M, Moochhala S: Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 2004, 202: 145-156. 10.1002/path.1491CrossRefPubMed
7.
Zurück zum Zitat Kubo H: Molecular basis of lung tissue regeneration. Gen Thorac Cardiovasc Surg 2011, 59: 231-244. 10.1007/s11748-010-0757-xCrossRefPubMed Kubo H: Molecular basis of lung tissue regeneration. Gen Thorac Cardiovasc Surg 2011, 59: 231-244. 10.1007/s11748-010-0757-xCrossRefPubMed
8.
Zurück zum Zitat Lindsay CD: Novel therapeutic strategies for acute lung injury induced by lung damaging agents: the potential role of growth factors as treatment options. Hum Exp Toxicol 2011, 30: 701-724. 10.1177/0960327110376982CrossRefPubMed Lindsay CD: Novel therapeutic strategies for acute lung injury induced by lung damaging agents: the potential role of growth factors as treatment options. Hum Exp Toxicol 2011, 30: 701-724. 10.1177/0960327110376982CrossRefPubMed
9.
Zurück zum Zitat Davey A, McAuley DF, O'Kane CM: Matrix metalloproteinases in acute lung injury: mediators of injury and drivers of repair. Eur Respir J 2011, 38: 959-970. 10.1183/09031936.00032111CrossRefPubMed Davey A, McAuley DF, O'Kane CM: Matrix metalloproteinases in acute lung injury: mediators of injury and drivers of repair. Eur Respir J 2011, 38: 959-970. 10.1183/09031936.00032111CrossRefPubMed
10.
Zurück zum Zitat Nin N, Lorente JA, de Paula M, et al.: Rats surviving injurious mechanical ventilation show reversible pulmonary, vascular and inflammatory changes. Intensive Care Med 2008, 34: 948-956. 10.1007/s00134-007-0959-6CrossRefPubMed Nin N, Lorente JA, de Paula M, et al.: Rats surviving injurious mechanical ventilation show reversible pulmonary, vascular and inflammatory changes. Intensive Care Med 2008, 34: 948-956. 10.1007/s00134-007-0959-6CrossRefPubMed
11.
Zurück zum Zitat Gonzalez-Lopez A, Astudillo A, Garcia-Prieto E, et al.: Inflammation and matrix remodeling during repair of ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 2011, 301: L500-L509. 10.1152/ajplung.00010.2011CrossRefPubMed Gonzalez-Lopez A, Astudillo A, Garcia-Prieto E, et al.: Inflammation and matrix remodeling during repair of ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 2011, 301: L500-L509. 10.1152/ajplung.00010.2011CrossRefPubMed
12.
Zurück zum Zitat Abraham E: Neutrophils and acute lung injury. Crit Care Med 2003, 31: S195-S199. 10.1097/01.CCM.0000057843.47705.E8CrossRefPubMed Abraham E: Neutrophils and acute lung injury. Crit Care Med 2003, 31: S195-S199. 10.1097/01.CCM.0000057843.47705.E8CrossRefPubMed
13.
Zurück zum Zitat Korpos E, Wu C, Sorokin L: Multiple roles of the extracellular matrix in inflammation. Curr Pharm Des 2009, 15: 1349-1357. 10.2174/138161209787846685CrossRefPubMed Korpos E, Wu C, Sorokin L: Multiple roles of the extracellular matrix in inflammation. Curr Pharm Des 2009, 15: 1349-1357. 10.2174/138161209787846685CrossRefPubMed
14.
Zurück zum Zitat Lin M, Jackson P, Tester AM, et al.: Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro. Am J Pathol 2008, 173: 144-153. 10.2353/ajpath.2008.080081PubMedCentralCrossRefPubMed Lin M, Jackson P, Tester AM, et al.: Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro. Am J Pathol 2008, 173: 144-153. 10.2353/ajpath.2008.080081PubMedCentralCrossRefPubMed
15.
Zurück zum Zitat Van Lint P, Libert C: Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation. J Leukoc Biol 2007, 82: 1375-1381. 10.1189/jlb.0607338CrossRefPubMed Van Lint P, Libert C: Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation. J Leukoc Biol 2007, 82: 1375-1381. 10.1189/jlb.0607338CrossRefPubMed
16.
Zurück zum Zitat Harty MW, Muratore CS, Papa EF, et al.: Neutrophil depletion blocks early collagen degradation in repairing cholestatic rat livers. Am J Pathol 2010, 176: 1271-1281. 10.2353/ajpath.2010.090527PubMedCentralCrossRefPubMed Harty MW, Muratore CS, Papa EF, et al.: Neutrophil depletion blocks early collagen degradation in repairing cholestatic rat livers. Am J Pathol 2010, 176: 1271-1281. 10.2353/ajpath.2010.090527PubMedCentralCrossRefPubMed
17.
Zurück zum Zitat Parks WC: Matrix metalloproteinases in lung repair. Eur Respir J 2003,22(Suppl 44):36s-38s.CrossRef Parks WC: Matrix metalloproteinases in lung repair. Eur Respir J 2003,22(Suppl 44):36s-38s.CrossRef
18.
Zurück zum Zitat O'Kane CM, McKeown SW, Perkins GD, et al.: Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome. Crit Care Med 2009, 37: 2242-2249. 10.1097/CCM.0b013e3181a5506cCrossRefPubMed O'Kane CM, McKeown SW, Perkins GD, et al.: Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome. Crit Care Med 2009, 37: 2242-2249. 10.1097/CCM.0b013e3181a5506cCrossRefPubMed
19.
Zurück zum Zitat Albaiceta GM, Gutierrez-Fernandez A, Parra D, et al.: Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 2008, 294: L535-L543.CrossRefPubMed Albaiceta GM, Gutierrez-Fernandez A, Parra D, et al.: Lack of matrix metalloproteinase-9 worsens ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 2008, 294: L535-L543.CrossRefPubMed
20.
Zurück zum Zitat Nerusu KC, Warner RL, Bhagavathula N, McClintock SD, Johnson KJ, Varani J: Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury. Exp Mol Pathol 2007, 83: 169-176. 10.1016/j.yexmp.2007.04.003PubMedCentralCrossRefPubMed Nerusu KC, Warner RL, Bhagavathula N, McClintock SD, Johnson KJ, Varani J: Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury. Exp Mol Pathol 2007, 83: 169-176. 10.1016/j.yexmp.2007.04.003PubMedCentralCrossRefPubMed
21.
Zurück zum Zitat Yamashita CM, Dolgonos L, Zemans RL, et al.: Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Am J Pathol 2011, 179: 1733-1745. 10.1016/j.ajpath.2011.06.041PubMedCentralCrossRefPubMed Yamashita CM, Dolgonos L, Zemans RL, et al.: Matrix metalloproteinase 3 is a mediator of pulmonary fibrosis. Am J Pathol 2011, 179: 1733-1745. 10.1016/j.ajpath.2011.06.041PubMedCentralCrossRefPubMed
22.
Zurück zum Zitat Albaiceta GM, Gutierrez-Fernandez A, Garcia-Prieto E, et al.: Absence or inhibition of matrix metalloproteinase-8 decreases ventilator-induced lung injury. Am J Respir Cell Mol Biol 2010, 43: 555-563. 10.1165/rcmb.2009-0034OCCrossRefPubMed Albaiceta GM, Gutierrez-Fernandez A, Garcia-Prieto E, et al.: Absence or inhibition of matrix metalloproteinase-8 decreases ventilator-induced lung injury. Am J Respir Cell Mol Biol 2010, 43: 555-563. 10.1165/rcmb.2009-0034OCCrossRefPubMed
23.
Zurück zum Zitat Garcia-Prieto E, Gonzalez-Lopez A, Cabrera S, et al.: Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10. PLoS One 2010, 5: e13242. 10.1371/journal.pone.0013242PubMedCentralCrossRefPubMed Garcia-Prieto E, Gonzalez-Lopez A, Cabrera S, et al.: Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10. PLoS One 2010, 5: e13242. 10.1371/journal.pone.0013242PubMedCentralCrossRefPubMed
24.
Zurück zum Zitat Quintero PA, Knolle MD, Cala LF, Zhuang Y, Owen CA: Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice. J Immunol 2010, 184: 1575-1588. 10.4049/jimmunol.0900290PubMedCentralCrossRefPubMed Quintero PA, Knolle MD, Cala LF, Zhuang Y, Owen CA: Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice. J Immunol 2010, 184: 1575-1588. 10.4049/jimmunol.0900290PubMedCentralCrossRefPubMed
25.
Zurück zum Zitat Gueders MM, Balbin M, Rocks N, et al.: Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J Immunol 2005, 175: 2589-2597.CrossRefPubMed Gueders MM, Balbin M, Rocks N, et al.: Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J Immunol 2005, 175: 2589-2597.CrossRefPubMed
26.
Zurück zum Zitat Chesnutt AN, Matthay MA, Tibayan FA, Clark JG: Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance. Am J Respir Crit Care Med 1997, 156: 840-845.CrossRefPubMed Chesnutt AN, Matthay MA, Tibayan FA, Clark JG: Early detection of type III procollagen peptide in acute lung injury. Pathogenetic and prognostic significance. Am J Respir Crit Care Med 1997, 156: 840-845.CrossRefPubMed
27.
Zurück zum Zitat Quesnel C, Nardelli L, Piednoir P, et al.: Alveolar fibroblasts in acute lung injury: biological behaviour and clinical relevance. Eur Respir J 2010, 35: 1312-1321. 10.1183/09031936.00074709CrossRefPubMed Quesnel C, Nardelli L, Piednoir P, et al.: Alveolar fibroblasts in acute lung injury: biological behaviour and clinical relevance. Eur Respir J 2010, 35: 1312-1321. 10.1183/09031936.00074709CrossRefPubMed
28.
Zurück zum Zitat Yoon HK, Cho HY, Kleeberger SR: Protective role of matrix metalloproteinase-9 in ozone-induced airway inflammation. Environ Health Perspect 2007, 115: 1557-1563. 10.1289/ehp.10289PubMedCentralCrossRefPubMed Yoon HK, Cho HY, Kleeberger SR: Protective role of matrix metalloproteinase-9 in ozone-induced airway inflammation. Environ Health Perspect 2007, 115: 1557-1563. 10.1289/ehp.10289PubMedCentralCrossRefPubMed
29.
Zurück zum Zitat Verghese GM, McCormick-Shannon K, Mason RJ, Matthay MA: Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance. Am J Respir Crit Care Med 1998, 158: 386-394.CrossRefPubMed Verghese GM, McCormick-Shannon K, Mason RJ, Matthay MA: Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance. Am J Respir Crit Care Med 1998, 158: 386-394.CrossRefPubMed
30.
Zurück zum Zitat Rogel MR, Soni PN, Troken JR, Sitikov A, Trejo HE, Ridge KM: Vimentin is sufficient and required for wound repair and remodeling in alveolar epithelial cells. FASEB J, in press. Rogel MR, Soni PN, Troken JR, Sitikov A, Trejo HE, Ridge KM: Vimentin is sufficient and required for wound repair and remodeling in alveolar epithelial cells. FASEB J, in press.
31.
Zurück zum Zitat Losa D, Chanson M, Crespin S: Connexins as therapeutic targets in lung disease. Expert Opin Ther Targets 2011, 15: 989-1002. 10.1517/14728222.2011.584875CrossRefPubMed Losa D, Chanson M, Crespin S: Connexins as therapeutic targets in lung disease. Expert Opin Ther Targets 2011, 15: 989-1002. 10.1517/14728222.2011.584875CrossRefPubMed
32.
Zurück zum Zitat Vadivel A, Abozaid S, van Haaften T, et al.: Adrenomedullin promotes lung angiogenesis, alveolar development, and repair. Am J Respir Cell Mol Biol 2010, 43: 152-160. 10.1165/rcmb.2009-0004OCCrossRefPubMed Vadivel A, Abozaid S, van Haaften T, et al.: Adrenomedullin promotes lung angiogenesis, alveolar development, and repair. Am J Respir Cell Mol Biol 2010, 43: 152-160. 10.1165/rcmb.2009-0004OCCrossRefPubMed
33.
Zurück zum Zitat Liu Y, Sadikot RT, Adami GR, et al.: FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa. J Exp Med 2011, 208: 1473-1484. 10.1084/jem.20102041PubMedCentralCrossRefPubMed Liu Y, Sadikot RT, Adami GR, et al.: FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa. J Exp Med 2011, 208: 1473-1484. 10.1084/jem.20102041PubMedCentralCrossRefPubMed
34.
Zurück zum Zitat Lee JM, Kwon HJ, Bae SC, Jung HS: Lung tissue regeneration after induced injury in Runx3 KO mice. Cell Tissue Res 2010, 341: 465-470. 10.1007/s00441-010-1011-7CrossRefPubMed Lee JM, Kwon HJ, Bae SC, Jung HS: Lung tissue regeneration after induced injury in Runx3 KO mice. Cell Tissue Res 2010, 341: 465-470. 10.1007/s00441-010-1011-7CrossRefPubMed
35.
Zurück zum Zitat Plataki M, Lee YD, Rasmussen DL, Hubmayr RD: Poloxamer 188 facilitates the repair of alveolus resident cells in ventilator injured lungs. Am J Respir Crit Care Med 2011, 184: 939-947. 10.1164/rccm.201104-0647OCPubMedCentralCrossRefPubMed Plataki M, Lee YD, Rasmussen DL, Hubmayr RD: Poloxamer 188 facilitates the repair of alveolus resident cells in ventilator injured lungs. Am J Respir Crit Care Med 2011, 184: 939-947. 10.1164/rccm.201104-0647OCPubMedCentralCrossRefPubMed
36.
Zurück zum Zitat Giangreco A, Arwert EN, Rosewell IR, Snyder J, Watt FM, Stripp BR: Stem cells are dispensable for lung homeostasis but restore airways after injury. Proc Natl Acad Sci USA 2009, 106: 9286-9291. 10.1073/pnas.0900668106PubMedCentralCrossRefPubMed Giangreco A, Arwert EN, Rosewell IR, Snyder J, Watt FM, Stripp BR: Stem cells are dispensable for lung homeostasis but restore airways after injury. Proc Natl Acad Sci USA 2009, 106: 9286-9291. 10.1073/pnas.0900668106PubMedCentralCrossRefPubMed
37.
Zurück zum Zitat Yang KY, Shih HC, How CK, et al.: IV delivery of induced pluripotent stem cells attenuates endotoxin-induced acute lung injury in mice. Chest 2011, 140: 1243-1253. 10.1378/chest.11-0539CrossRefPubMed Yang KY, Shih HC, How CK, et al.: IV delivery of induced pluripotent stem cells attenuates endotoxin-induced acute lung injury in mice. Chest 2011, 140: 1243-1253. 10.1378/chest.11-0539CrossRefPubMed
38.
Zurück zum Zitat Curley GF, Contreras M, Higgins BD, O'Toole DP, Laffey JG: The role of mesenchymal stem cells during repair from ventilator induced lung injury. J Respir Crit Care Med, in press. Curley GF, Contreras M, Higgins BD, O'Toole DP, Laffey JG: The role of mesenchymal stem cells during repair from ventilator induced lung injury. J Respir Crit Care Med, in press.
39.
Zurück zum Zitat Plopper CG, St George JA, Read LC, et al.: Acceleration of alveolar type II cell differentiation in fetal rhesus monkey lung by administration of EGF. Am J Physiol 1992, 262: L313-L321.PubMed Plopper CG, St George JA, Read LC, et al.: Acceleration of alveolar type II cell differentiation in fetal rhesus monkey lung by administration of EGF. Am J Physiol 1992, 262: L313-L321.PubMed
40.
Zurück zum Zitat Harada C, Kawaguchi T, Ogata-Suetsugu S, et al.: EGFR tyrosine kinase inhibition worsens acute lung injury in mice with repairing airway epithelium. Am J Respir Crit Care Med 2011, 183: 743-751. 10.1164/rccm.201002-0188OCCrossRefPubMed Harada C, Kawaguchi T, Ogata-Suetsugu S, et al.: EGFR tyrosine kinase inhibition worsens acute lung injury in mice with repairing airway epithelium. Am J Respir Crit Care Med 2011, 183: 743-751. 10.1164/rccm.201002-0188OCCrossRefPubMed
41.
Zurück zum Zitat Panoskaltsis-Mortari A, Ingbar DH, Jung P, et al.: KGF pretreatment decreases B7 and granzyme B expression and hastens repair in lungs of mice after allogeneic BMT. Am J Physiol Lung Cell Mol Physiol 2000, 278: L988-L999.PubMed Panoskaltsis-Mortari A, Ingbar DH, Jung P, et al.: KGF pretreatment decreases B7 and granzyme B expression and hastens repair in lungs of mice after allogeneic BMT. Am J Physiol Lung Cell Mol Physiol 2000, 278: L988-L999.PubMed
42.
Zurück zum Zitat Dohi M, Hasegawa T, Yamamoto K, Marshall BC: Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis. Am J Respir Crit Care Med 2000, 162: 2302-2307.CrossRefPubMed Dohi M, Hasegawa T, Yamamoto K, Marshall BC: Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis. Am J Respir Crit Care Med 2000, 162: 2302-2307.CrossRefPubMed
43.
Zurück zum Zitat Medford AR, Millar AB: Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm? Thorax 2006, 61: 621-626. 10.1136/thx.2005.040204PubMedCentralCrossRefPubMed Medford AR, Millar AB: Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm? Thorax 2006, 61: 621-626. 10.1136/thx.2005.040204PubMedCentralCrossRefPubMed
44.
Zurück zum Zitat Perkins GD, McAuley DF, Thickett DR, Gao F: The beta-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial. Am J Respir Crit Care Med 2006, 173: 281-287. 10.1164/rccm.200508-1302OCCrossRefPubMed Perkins GD, McAuley DF, Thickett DR, Gao F: The beta-agonist lung injury trial (BALTI): a randomized placebo-controlled clinical trial. Am J Respir Crit Care Med 2006, 173: 281-287. 10.1164/rccm.200508-1302OCCrossRefPubMed
45.
Zurück zum Zitat Perkins GD, Gao F, Thickett DR: In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury. Thorax 2008, 63: 215-220. 10.1136/thx.2007.080382CrossRefPubMed Perkins GD, Gao F, Thickett DR: In vivo and in vitro effects of salbutamol on alveolar epithelial repair in acute lung injury. Thorax 2008, 63: 215-220. 10.1136/thx.2007.080382CrossRefPubMed
46.
Zurück zum Zitat Matthay MA, Brower RG, Carson S, et al.: Randomized, placebo-controlled clinical trial of an aerosolized beta-2 agonist for treatment of acute lung injury. Am J Respir Crit Care Med 2011, 184: 561-568.CrossRefPubMed Matthay MA, Brower RG, Carson S, et al.: Randomized, placebo-controlled clinical trial of an aerosolized beta-2 agonist for treatment of acute lung injury. Am J Respir Crit Care Med 2011, 184: 561-568.CrossRefPubMed
Metadaten
Titel
Repair after acute lung injury: molecular mechanisms and therapeutic opportunities
verfasst von
Adrián González-López
Guillermo M Albaiceta
Publikationsdatum
01.04.2012
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 2/2012
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc11224

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