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Erschienen in: International Ophthalmology 1/2024

01.12.2024 | Original Paper

Selective laser trabeculoplasty in the treatment of juvenile open angle glaucoma patients under 25 years of age

verfasst von: Ekrem Kurnaz

Erschienen in: International Ophthalmology | Ausgabe 1/2024

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Abstract

Aim

To retrospectively evaluate the effectiveness and reliability of selective laser trabeculoplasty (SLT) treatment in juvenile open angle glaucoma (JOAG) cases.

Material and method

The 46 eyes of 28 cases that had undergone SLT for JOAG and had a follow-up of at least one month were included in the study. The pre-SLT, month 1, month 6, year 1, year 2, and final follow-up intraocular pressure (IOP); the number of drugs before and after the SLT procedure; and the complications caused by the SLT were recorded. An IOP below 21 mmHg without any additional medication or glaucoma surgery and an IOP decrease of 20% or more compared to the baseline were considered successful.

Results

There were 18 females and 10 males with a mean age of 17.52 ± 2.7 (13–22) years. The cases were followed-up for a mean duration of 39 (5–59) months. The mean IOP was 23.93 ± 0.52 mmHg before SLT and decreased to 17.15 ± 0.57 mmHg at month 1 after the procedure, 17.17 ± 0.52 mmHg at month 6, 18.02 ± 0.77 mmHg at year 1, 18.12 ± 0.48 mmHg at year 2, and 20.93 ± 0.69 mmHg at the final follow-up. The post-SLT IOP measurements at all times were found to be significantly lower than the pre-SLT values (p < 0.001). The mean number of drugs was 1.5 before the SLT and 0.59 afterwards (p < 0.001). The most common complications after SLT were anterior chamber inflammation in 29 cases (63.04%), hyperemia in 20 (43.40%) cases (4.34%), an early period IOP increase of 5 mmHg or more in 11 cases (23.91%), and mild ocular pain in 2 cases (4.34%).

Conclusion

SLT is an effective and reliable method for JOAG treatment.
Literatur
1.
Zurück zum Zitat European Glaucoma Society (2008) Terminology and guidelines for glaucoma, 3rd edn (2.2.1), p 95 European Glaucoma Society (2008) Terminology and guidelines for glaucoma, 3rd edn (2.2.1), p 95
2.
3.
Zurück zum Zitat Goldwyn R, Waltman SR, Becker B (1970) Primary open-angle glaucoma in adolescents and young adults. Arch Ophthalmol 84(5):579–582PubMedCrossRef Goldwyn R, Waltman SR, Becker B (1970) Primary open-angle glaucoma in adolescents and young adults. Arch Ophthalmol 84(5):579–582PubMedCrossRef
4.
Zurück zum Zitat Marshall LL, Hayslett RL, Stevens GA (2018) Therapy for open-angle glaucoma. Consult Pharm 33(8):432–445PubMedCrossRef Marshall LL, Hayslett RL, Stevens GA (2018) Therapy for open-angle glaucoma. Consult Pharm 33(8):432–445PubMedCrossRef
5.
Zurück zum Zitat Chardoub AAJ, Blair K (2022) Juvenile glaucoma. StatPearls Publishing Chardoub AAJ, Blair K (2022) Juvenile glaucoma. StatPearls Publishing
6.
Zurück zum Zitat Talbot AW, Russel-Eggit I (2000) Pharmaceutical management of the childhood glaucomas. Expert Opin Pharmacother 1(4):697–711PubMedCrossRef Talbot AW, Russel-Eggit I (2000) Pharmaceutical management of the childhood glaucomas. Expert Opin Pharmacother 1(4):697–711PubMedCrossRef
7.
Zurück zum Zitat Wiggs JL, Del Bono EA, Schuman JS, Hutchinson BT, Walton DS (1995) Clinical features of five pedigrees genetically linked to the juvenile glaucoma locus on chromosome 1q21-q31. Ophthalmology 102(12):1782–1789PubMedCrossRef Wiggs JL, Del Bono EA, Schuman JS, Hutchinson BT, Walton DS (1995) Clinical features of five pedigrees genetically linked to the juvenile glaucoma locus on chromosome 1q21-q31. Ophthalmology 102(12):1782–1789PubMedCrossRef
8.
Zurück zum Zitat Johnson AT, Drack AV, Kwitek AE, Cannon RL, Stone EM, Alward WL (1993) Clinical features and linkage analysis of a family with autosomal dominant juvenile glaucoma. Ophthalmology 100(4):524–529PubMedCrossRef Johnson AT, Drack AV, Kwitek AE, Cannon RL, Stone EM, Alward WL (1993) Clinical features and linkage analysis of a family with autosomal dominant juvenile glaucoma. Ophthalmology 100(4):524–529PubMedCrossRef
9.
Zurück zum Zitat Ikeda H, Ishigooka H, Muto T, Tanihara H, Nagata M (2004) Long-term outcome of trabeculotomy for the treatment of developmental glaucoma. Arch Ophthalmol 122(8):1122–1128PubMedCrossRef Ikeda H, Ishigooka H, Muto T, Tanihara H, Nagata M (2004) Long-term outcome of trabeculotomy for the treatment of developmental glaucoma. Arch Ophthalmol 122(8):1122–1128PubMedCrossRef
10.
Zurück zum Zitat Pathania D, Senthil S, Rao HL, Mandal AK, Garudadari CS (2014) Outcomes of trabeculectomy in juvenile open angle glaucoma. Indian J Ophthalmol 62(2):224–228PubMedPubMedCentralCrossRef Pathania D, Senthil S, Rao HL, Mandal AK, Garudadari CS (2014) Outcomes of trabeculectomy in juvenile open angle glaucoma. Indian J Ophthalmol 62(2):224–228PubMedPubMedCentralCrossRef
11.
Zurück zum Zitat Tsai JC, Chang HW, Kao CN, Lai IC, Teng MC (2003) Trabeculectomy with mitomycin C versus trabeculectomy alone for juvenile primary open-angle glaucoma. Ophthalmologica 217(1):24–30PubMedCrossRef Tsai JC, Chang HW, Kao CN, Lai IC, Teng MC (2003) Trabeculectomy with mitomycin C versus trabeculectomy alone for juvenile primary open-angle glaucoma. Ophthalmologica 217(1):24–30PubMedCrossRef
12.
Zurück zum Zitat Mark A, Latina MD, Joseph AJ, Tumbocon MD (2002) Selective laser trabeculoplasty: a new treatment option for open angle glaucoma. Curr Opinion Ophthalmol 13:94–96CrossRef Mark A, Latina MD, Joseph AJ, Tumbocon MD (2002) Selective laser trabeculoplasty: a new treatment option for open angle glaucoma. Curr Opinion Ophthalmol 13:94–96CrossRef
13.
Zurück zum Zitat Stangos AN, Whatham AR, Sunaric-Megevand G (2005) Primary viscocanalostomy for juvenile open-angle glaucoma. Am J Ophthalmol 140(3):490–496PubMedCrossRef Stangos AN, Whatham AR, Sunaric-Megevand G (2005) Primary viscocanalostomy for juvenile open-angle glaucoma. Am J Ophthalmol 140(3):490–496PubMedCrossRef
14.
Zurück zum Zitat Congdon N, Azuara-Blanco A, Solberg Y et al (2021) Direct selective laser trabeculoplasty in open angle glaucoma study design: a multicentre, randomised, controlled, investigator-masked trial (GLAUrious). Br J ophthalmol 0:1–4 Congdon N, Azuara-Blanco A, Solberg Y et al (2021) Direct selective laser trabeculoplasty in open angle glaucoma study design: a multicentre, randomised, controlled, investigator-masked trial (GLAUrious). Br J ophthalmol 0:1–4
15.
Zurück zum Zitat Agarwal HC, Sihota R, Das C, Dada T (2002) Role of argon laser trabeculoplasty as primary and secondary therapy in open angle glaucoma in Indian patients. Br J Ophthalmol 86:733–736PubMedPubMedCentralCrossRef Agarwal HC, Sihota R, Das C, Dada T (2002) Role of argon laser trabeculoplasty as primary and secondary therapy in open angle glaucoma in Indian patients. Br J Ophthalmol 86:733–736PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Ansari E (2021) 10-year outcomes of first-line selective laser trabeculoplasty (SLT) for primary open-angle glaucoma (POAG). Graefe’s Arch Clin Exp Ophthalmol 259:1597–1604CrossRef Ansari E (2021) 10-year outcomes of first-line selective laser trabeculoplasty (SLT) for primary open-angle glaucoma (POAG). Graefe’s Arch Clin Exp Ophthalmol 259:1597–1604CrossRef
17.
Zurück zum Zitat Ticho U, Nesher R (1989) Laser trabeculoplasty in glaucoma: ten-year evaluation. Arch Ophthalmol 107:844–846PubMedCrossRef Ticho U, Nesher R (1989) Laser trabeculoplasty in glaucoma: ten-year evaluation. Arch Ophthalmol 107:844–846PubMedCrossRef
18.
Zurück zum Zitat Investigators AGIS (2002) The advanced glaucoma intervention study (AGIS), 11: risk factors for failure of trabeculectomy and argon laser trabeculoplasty. Am J Ophthalmol 134:481–498CrossRef Investigators AGIS (2002) The advanced glaucoma intervention study (AGIS), 11: risk factors for failure of trabeculectomy and argon laser trabeculoplasty. Am J Ophthalmol 134:481–498CrossRef
19.
Zurück zum Zitat The Glaucoma Laser Trial Research Group (1995) The Glaucoma Laser Trial (GLT) and glaucoma laser trial follow-up study, seven-year results. Am J Ophthalmol 120:718–731CrossRef The Glaucoma Laser Trial Research Group (1995) The Glaucoma Laser Trial (GLT) and glaucoma laser trial follow-up study, seven-year results. Am J Ophthalmol 120:718–731CrossRef
20.
Zurück zum Zitat Latina M, Park C (1995) Selective targeting of trabecular meshwork cells: in vitro studies of pulse and continuous laser interactions. Exp Eye Res 60:359–372PubMedCrossRef Latina M, Park C (1995) Selective targeting of trabecular meshwork cells: in vitro studies of pulse and continuous laser interactions. Exp Eye Res 60:359–372PubMedCrossRef
21.
Zurück zum Zitat Kramer TR, Noecker RJ (2001) Comparison of the morphologic changes after selective laser trabeculoplasty in human eye bank eyes. Ophthalmology 108:773–779PubMedCrossRef Kramer TR, Noecker RJ (2001) Comparison of the morphologic changes after selective laser trabeculoplasty in human eye bank eyes. Ophthalmology 108:773–779PubMedCrossRef
22.
Zurück zum Zitat Kun Hong B, Winer JC, Martone JF et al (2009) Repeat selective laser trabeculoplasty. J Glaucoma 18(3):180–183CrossRef Kun Hong B, Winer JC, Martone JF et al (2009) Repeat selective laser trabeculoplasty. J Glaucoma 18(3):180–183CrossRef
23.
Zurück zum Zitat Eyawo O, Lee C-W, Rachlis B et al (2008) Reporting of noninferiority and equivalence randomized trials for major prostaglandins: a systematic survey of the ophthalmology literature. Trials 9:69PubMedPubMedCentralCrossRef Eyawo O, Lee C-W, Rachlis B et al (2008) Reporting of noninferiority and equivalence randomized trials for major prostaglandins: a systematic survey of the ophthalmology literature. Trials 9:69PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat Latina MA, Sibayan SA, Shin DH et al (1998) Q-switched 532-nm Nd:YAG laser trabeculoplasty (selective laser trabeculoplasty): a multicenter, pilot, clinical study. Ophthalmology 105:2082–2090PubMedCrossRef Latina MA, Sibayan SA, Shin DH et al (1998) Q-switched 532-nm Nd:YAG laser trabeculoplasty (selective laser trabeculoplasty): a multicenter, pilot, clinical study. Ophthalmology 105:2082–2090PubMedCrossRef
25.
Zurück zum Zitat Woo DM, Healey PR, Graham SL (2015) Intraocular pressure-lowering medications and long term outcomes of selective laser trabeculoplasty: glaucoma laser and medical therapy. Clin Exp Ophthalmol 43:320–327PubMedCrossRef Woo DM, Healey PR, Graham SL (2015) Intraocular pressure-lowering medications and long term outcomes of selective laser trabeculoplasty: glaucoma laser and medical therapy. Clin Exp Ophthalmol 43:320–327PubMedCrossRef
26.
Zurück zum Zitat El Mallah MK, Walsh MM, Stinnett SS et al (2010) Selective laser trabeculoplasty reduces mean IOP and IOP variation in normal tension glaucoma patients. Clin Ophthalmol 4:889–893PubMedPubMedCentral El Mallah MK, Walsh MM, Stinnett SS et al (2010) Selective laser trabeculoplasty reduces mean IOP and IOP variation in normal tension glaucoma patients. Clin Ophthalmol 4:889–893PubMedPubMedCentral
27.
Zurück zum Zitat Pan YI, Damji KF, Rock W et al (2004) Highly successful SLT is independent of glaucoma risk factors. Invest Ophthalmol Vis Sci 45:4456 Pan YI, Damji KF, Rock W et al (2004) Highly successful SLT is independent of glaucoma risk factors. Invest Ophthalmol Vis Sci 45:4456
28.
Zurück zum Zitat Hodge WG, Damji KF, Rock W et al (2005) Baseline IOP predicts selective laser trabeculoplasty success at 1 year post-treatment: results from a randomised clinical trial. Br J Ophthalmol 89:1157–1160PubMedPubMedCentralCrossRef Hodge WG, Damji KF, Rock W et al (2005) Baseline IOP predicts selective laser trabeculoplasty success at 1 year post-treatment: results from a randomised clinical trial. Br J Ophthalmol 89:1157–1160PubMedPubMedCentralCrossRef
29.
30.
Zurück zum Zitat Mills RP, Budenz DL, Lee PP et al (2006) Categorizing the stageof glaucoma from pre-diagnosis to end-stage disease. Am J Ophthalmol 141:24–30PubMedCrossRef Mills RP, Budenz DL, Lee PP et al (2006) Categorizing the stageof glaucoma from pre-diagnosis to end-stage disease. Am J Ophthalmol 141:24–30PubMedCrossRef
31.
Zurück zum Zitat Spaeth GL (1971) The normal development of the human anterior chamber angle: a new system of descriptive grading. Trans Ophthalmol Soc UK 91:709–739PubMed Spaeth GL (1971) The normal development of the human anterior chamber angle: a new system of descriptive grading. Trans Ophthalmol Soc UK 91:709–739PubMed
32.
Zurück zum Zitat Leahy KE, White AJ (2015) Selective laser trabeculoplasty: current perspectives. Clin Ophthalmol 11:833–841 Leahy KE, White AJ (2015) Selective laser trabeculoplasty: current perspectives. Clin Ophthalmol 11:833–841
33.
Zurück zum Zitat Song J, Song A, Palmares T, Song M (2013) Selective laser trabeculoplasty success in pediatric patients with glaucoma: two case reports. J Med Case Rep 7:198PubMedPubMedCentralCrossRef Song J, Song A, Palmares T, Song M (2013) Selective laser trabeculoplasty success in pediatric patients with glaucoma: two case reports. J Med Case Rep 7:198PubMedPubMedCentralCrossRef
34.
Zurück zum Zitat Lui Y, Birt CM (2012) Argon versus selective laser trabeculoplasty in younger patients: 2-years results. J Glaucoma 21:112–115 Lui Y, Birt CM (2012) Argon versus selective laser trabeculoplasty in younger patients: 2-years results. J Glaucoma 21:112–115
35.
Zurück zum Zitat Gupta V, Ghosh S, Chaudhary S et al (2018) Selective laser trabeculoplasty for primary open-angle glaucoma patients younger than 40 years. Can J Ophthalmol 53(1):81–85PubMedCrossRef Gupta V, Ghosh S, Chaudhary S et al (2018) Selective laser trabeculoplasty for primary open-angle glaucoma patients younger than 40 years. Can J Ophthalmol 53(1):81–85PubMedCrossRef
36.
Zurück zum Zitat Lui D, Chen D, Tan Q et al (2020) Outcome of selective laser trabeculoplasty in young patients with primary open-angle glaucoma and ocular hypertension. J Ophthalmol 8:1–6 Lui D, Chen D, Tan Q et al (2020) Outcome of selective laser trabeculoplasty in young patients with primary open-angle glaucoma and ocular hypertension. J Ophthalmol 8:1–6
37.
Zurück zum Zitat Baser EF, Akbulut D (2015) Significant peripheral anterior synechiae after repeat selective laser trabeculoplasty. Can J Ophthalmol 50(3):36–38CrossRef Baser EF, Akbulut D (2015) Significant peripheral anterior synechiae after repeat selective laser trabeculoplasty. Can J Ophthalmol 50(3):36–38CrossRef
38.
Zurück zum Zitat Weinnand FS, Althen F (2006) Long-term clinical results of selective laser trabeculoplasty in the treatment of primary open angle glaucoma. Eur J Ophthalmol 16:100–104CrossRef Weinnand FS, Althen F (2006) Long-term clinical results of selective laser trabeculoplasty in the treatment of primary open angle glaucoma. Eur J Ophthalmol 16:100–104CrossRef
39.
Zurück zum Zitat Schlote T, Kynigopoulos M (2016) Selective laser trabeculoplasty: 1 year results in early and advanced open angle glaucoma. Int Ophthalmol 365:55–61CrossRef Schlote T, Kynigopoulos M (2016) Selective laser trabeculoplasty: 1 year results in early and advanced open angle glaucoma. Int Ophthalmol 365:55–61CrossRef
40.
Zurück zum Zitat Francis BA, Ianchulev T, Schofield JK et al (2005) Selective laser trabeculoplasty as a replacement for medical therapy in open-angle glaucoma. Am J Ophthalmol 140:524–525PubMedCrossRef Francis BA, Ianchulev T, Schofield JK et al (2005) Selective laser trabeculoplasty as a replacement for medical therapy in open-angle glaucoma. Am J Ophthalmol 140:524–525PubMedCrossRef
41.
Zurück zum Zitat Lee JW, Chan CV, Wong MO et al (2014) A randomized control trial to evaluate the effect of adjuvant selective laser trabeculoplasty versus medication alone in primary open-angle glaucoma: preliminary results. Clin Ophthalmol 8:1987–1992PubMedPubMedCentralCrossRef Lee JW, Chan CV, Wong MO et al (2014) A randomized control trial to evaluate the effect of adjuvant selective laser trabeculoplasty versus medication alone in primary open-angle glaucoma: preliminary results. Clin Ophthalmol 8:1987–1992PubMedPubMedCentralCrossRef
42.
Zurück zum Zitat Lee R, Hutnik VML (2006) Projected cost comparison of selective laser trabeculoplasty versus glaucoma medication in the Ontario Health Insurance Plan. Can J Ophthalmol 41:449–456PubMedCrossRef Lee R, Hutnik VML (2006) Projected cost comparison of selective laser trabeculoplasty versus glaucoma medication in the Ontario Health Insurance Plan. Can J Ophthalmol 41:449–456PubMedCrossRef
43.
Zurück zum Zitat Wong MO, Lee JW, Choy BN et al (2015) Systemic review and meta-analysis on the efficacy of selective laser trabeculoplasty in open-angle glaucoma. Surv Ophthalmol 60:36–50PubMedCrossRef Wong MO, Lee JW, Choy BN et al (2015) Systemic review and meta-analysis on the efficacy of selective laser trabeculoplasty in open-angle glaucoma. Surv Ophthalmol 60:36–50PubMedCrossRef
45.
Zurück zum Zitat Rhodes KM, Weinstein R, Saltzmann RM et al (2009) Intra ocular pressure reduction in the untreated fellow eye after selective laser trabeculoplasty. Curr Med Res Opin 25:787–796PubMedCrossRef Rhodes KM, Weinstein R, Saltzmann RM et al (2009) Intra ocular pressure reduction in the untreated fellow eye after selective laser trabeculoplasty. Curr Med Res Opin 25:787–796PubMedCrossRef
46.
Zurück zum Zitat Kara N, Altınkaynak H, Şatana B et al (2011) Evaluation of factors influencing outcomes of selective laser trabeculoplasty in primary open angle glaucoma. Turk J Ophthalmol 41:304–308CrossRef Kara N, Altınkaynak H, Şatana B et al (2011) Evaluation of factors influencing outcomes of selective laser trabeculoplasty in primary open angle glaucoma. Turk J Ophthalmol 41:304–308CrossRef
Metadaten
Titel
Selective laser trabeculoplasty in the treatment of juvenile open angle glaucoma patients under 25 years of age
verfasst von
Ekrem Kurnaz
Publikationsdatum
01.12.2024
Verlag
Springer Netherlands
Erschienen in
International Ophthalmology / Ausgabe 1/2024
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-024-03108-7

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