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Journal of Endocrinological Investigation
Erschienen in: Journal of Endocrinological Investigation 8/2023

01.08.2023 | Review

Sex differences in glycolipidic disorders after exposure to maternal hyperglycemia during early development

verfasst von: S.-s. Luo, H. Zhu, H-f. Huang, G.-l. Ding

Erschienen in: Journal of Endocrinological Investigation | Ausgabe 8/2023

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Abstract

Purpose

The aim of this review was to summarize sex differences in glycolipid metabolic phenotypes of human and animal models after exposure to maternal hyperglycemia and overview the underlying mechanisms, providing a new perspective on the maternal hyperglycemia-triggered risk of glycolipidic disorders in offspring.

Methods

A comprehensive literature search within PubMed was performed. Selected publications related to studies on offspring exposed to maternal hyperglycemia investigating the sex differences of glycolipid metabolism were reviewed.

Results

Maternal hyperglycemia increases the risk of glycolipid metabolic disorders in offspring, such as obesity, glucose intolerance and diabetes. Whether with or without intervention, metabolic phenotypes have been shown to exhibit sex differences between male and female offspring in response to maternal hyperglycemia, which may be related to gonadal hormones, organic intrinsic differences, placenta, and epigenetic modifications.

Conclusion

Sex may play a role in the different incidences and pathogenesis of abnormal glycolipid metabolism. More studies investigating both sexes are needed to understand how and why environmental conditions in early life affect long-term health between male and female individuals.
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Metadaten
Titel
Sex differences in glycolipidic disorders after exposure to maternal hyperglycemia during early development
verfasst von
S.-s. Luo
H. Zhu
H-f. Huang
G.-l. Ding
Publikationsdatum
01.08.2023
Verlag
Springer International Publishing
Erschienen in
Journal of Endocrinological Investigation / Ausgabe 8/2023
Elektronische ISSN: 1720-8386
DOI
https://doi.org/10.1007/s40618-023-02069-5

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