Erschienen in:
01.06.2015 | Original Article
Significant relationship between preoperative serum concentration of anti-heat shock protein 70 antibody and postoperative morbidity in patients with esophageal cancer
verfasst von:
M. Nakajima, MD, PhD, FACS, H. Kato, MD, PhD, FACS, M. Sakai, MD, PhD, A. Sano, MD, PhD, T. Miyazaki, MD, PhD, FACS, M. Sohda, MD, PhD, T. Inose, MD, PhD, T. Yokobori, MD, PhD, N. Tanaka, MD, PhD, S. Suzuki, MD, N. Masuda, MD, PhD, M. Fukuchi, MD, PhD, H. Kuwano, MD, PhD, FACS
Erschienen in:
European Surgery
|
Ausgabe 3/2015
Einloggen, um Zugang zu erhalten
Summary
Background
Heat shock protein 70 is a molecular chaperone important in host responses to stress, including infection, injury, oxidative damage, hypoxia, and thermal stress. This study analyzed the correlation between preoperative serum concentrations of anti-HPS70 antibody and postoperative morbidity in patients with esophageal cancer.
Materials and methods
Serum samples were obtained preoperatively from 50 esophageal carcinoma patients (46 men and 4 women) who underwent potentially curative surgery without preoperative therapy. Serum anti-HSP70 antibody concentrations were measured by enzyme-linked immunosorbent assays.
Results
The mean concentration of anti-HSP70 antibody was 187.0 μg/mL. When patients were dichotomized relative to this cutoff, we observed no significant relationships between perioperative inflammatory markers (maximum body temperature, white blood cell count and C-reactive protein concentration) and anti-HSP70 antibody concentration. The incidence of postoperative complications was significantly lower in patients with anti-HSP ≥ 187.0 μg/mL than < 187.0 μg/mL (p = 0.0336).
Conclusions
Preoperative serum concentration of anti-HSP70 antibody was significantly related to postoperative morbidities in patients with esophageal cancer.