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Clinical Pharmacokinetics
Erschienen in: Clinical Pharmacokinetics 7/2007

01.07.2007 | Review Article

Strategies to Improve Drug Delivery Across the Blood-Brain Barrier

verfasst von: Dr Albertus G. de Boer, Pieter J. Gaillard

Erschienen in: Clinical Pharmacokinetics | Ausgabe 7/2007

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Abstract

The blood-brain barrier (BBB), together with the blood-cerebrospinal-fluid barrier, protects and regulates the homeostasis of the brain. However, these barriers also limit the transport of small-molecule and, particularly, biopharmaceutical drugs such as proteins, genes and interference RNA to the brain, thereby limiting the treatment of many brain diseases. As a result, various drug delivery and targeting strategies are currently being developed to enhance the transport and distribution of drugs into the brain. In this review, we discuss briefly the biology and physiology of the BBB as the most important barrier for drug transport to the brain and, in more detail, the possibilities for delivering large-molecule drugs, particularly genes, by receptor-mediated nonviral drug delivery to the (human) brain. In addition, the systemic and intracellular pharmacokinetics of nonviral gene delivery, together with targeted brain imaging, are reviewed briefly.
Fußnoten
1
The use of trade names is for product identification purposes only and does not imply endorsement.
 
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Metadaten
Titel
Strategies to Improve Drug Delivery Across the Blood-Brain Barrier
verfasst von
Dr Albertus G. de Boer
Pieter J. Gaillard
Publikationsdatum
01.07.2007
Verlag
Springer International Publishing
Erschienen in
Clinical Pharmacokinetics / Ausgabe 7/2007
Print ISSN: 0312-5963
Elektronische ISSN: 1179-1926
DOI
https://doi.org/10.2165/00003088-200746070-00002

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